http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. Case Western Reserve's Technology Transfer Office has granted an exclusive license of a novel Alzheimer's Disease (AD) treatment strategy to spinoff company ReXceptor Inc., which plans to initiate early-stage human clinical trials of the medication within the next few months. http://medicalxpress.com/news/2013-04-spinoff-rexceptor-alzheimer-treatment.html Alzheimer's disease & dementia Thu, 25 Apr 2013 13:02:13 EST news286113727 An excess of the brain neurotransmitter glutamate may cause a transition to psychosis in people who are at risk for schizophrenia, reports a study from investigators at Columbia University Medical Center (CUMC) published in the current issue of Neuron. http://medicalxpress.com/news/2013-04-high-glutamate-brain-kick-start-schizophrenia.html Neuroscience Thu, 18 Apr 2013 11:39:15 EST news285503947 Poly (ADP-ribose) polymerase inhibitors may be a novel treatment strategy for patients with cancer that has become resistant to the commonly used chemotherapy drug cisplatin, according to data from a preclinical study published in Cancer Research, a journal of the American Association for Cancer Research. http://medicalxpress.com/news/2013-04-cisplatin-resistant-cancer-cells-sensitive-experimental.html Cancer Wed, 03 Apr 2013 00:20:01 EST news284141891 After an intensive three-year hunt through the genome, medical researchers have pinpointed mutations that leads to drug resistance and relapse in the most common type of childhood cancer—the first time anyone has linked the disease's reemergence to specific genetic anomalies. http://medicalxpress.com/news/2013-02-mutations-linked-relapse-childhood-leukemia.html Genetics Sun, 03 Feb 2013 13:00:04 EST news279114848 Scientists at Dana-Farber Cancer Institute have discovered a molecular switch that enables advanced prostate cancers to spread without stimulation by male hormones, which normally are needed to spur the cancer's growth. They say the finding could lead to a new treatment for prostate cancers that are no longer controlled by hormone-blocking drugs. http://medicalxpress.com/news/2012-12-culprit-castration-resistant-prostate-cancer.html Cancer Thu, 13 Dec 2012 14:19:08 EST news274630741 Rheumatoid arthritis is a chronic disease characterized by inflammation of the joints. A rapid suppression of inflammation is important for a good prognosis. Marloes Vermeer, a PhD student at the University of Twente, investigated the effects of a "Treat-to-Target treatment strategy". Ms Vermeer explains that "The new treatment appears to be feasible in daily clinical practice. Even after a period of three years, disease activity is more effectively suppressed than with conventional treatment." http://medicalxpress.com/news/2012-12-rheumatoid-arthritis-treatment-shown-effective.html Arthritis & Rheumatism Tue, 11 Dec 2012 08:28:43 EST news274436906 With active surveillance many men with prostate cancer could dispense with radiation treatment and surgery, and thus avoid adverse effects such as incontinence and impotence. This is the outcome of a study of almost 1,000 men diagnosed with prostate cancer conducted at Sahlgrenska Academy, University of Gothenburg, Sweden. http://medicalxpress.com/news/2012-11-surveillance-men-prostate-cancer.html Cancer Fri, 02 Nov 2012 12:10:46 EST news271077003 After leukaemia and brain tumours, neuroblastoma is the most common form of cancer to affect children. A thesis from the Sahlgrenska Academy, University of Gothenburg, Sweden, has studied a DNA method which is now used for all cases of neuroblastoma in Sweden, and which has led to more effective treatment at individual level. http://medicalxpress.com/news/2012-10-dna-method-effective-treatment-childhood.html Cancer Mon, 15 Oct 2012 11:38:43 EST news269519826 Poly (ADP-Ribose) polymerase (PARP) inhibitors, shown to have clinical activity when used alone in women with familial breast and ovarian cancers linked to BRCA mutations, may be a novel treatment strategy in women with HER2-positive breast cancers, according to the results of a study published in Cancer Research, a journal of the American Association for Cancer Research. http://medicalxpress.com/news/2012-09-parp-inhibitors-clinical-her2-positive-breast.html Cancer Mon, 17 Sep 2012 00:20:01 EST news267018005 Mutations of the gene Lmna previously thought to be directly responsible for a group of laminopathies—serious developmental conditions including premature aging and a form of muscular dystrophy—in fact cause them by allowing a critical protein to accumulate. An international collaborative group of researchers including Ya-Hui Chi and co-workers at the A*STAR Institute of Medical Biology have discovered in mice that reducing levels of the protein, Sun1, resulted in decreased severity of the diseases and longer life spans. This breakthrough finding may eventually lead to changes of the treatment strategy for developmental conditions. http://medicalxpress.com/news/2012-08-genetic-disease-linked-protein-build-up.html Medical research Wed, 29 Aug 2012 08:10:02 EST news265445934 (HealthDay) -- Diagnosis of low- or intermediate-grade tumors is associated with significantly better overall survival and disease-free survival in patients with mucoepidermoid carcinoma (MEC) of the salivary glands, while advanced disease stage and perineural invasion are the most significant indicators of poor prognosis, according to a study published in the Aug. 15 issue of Cancer. http://medicalxpress.com/news/2012-08-prognostic-factors-mucoepidermoid-carcinoma.html Cancer Fri, 10 Aug 2012 12:52:52 EST news263821949 (HealthDay) -- For patients with sacral giant cell tumors (GCTs), curettage alone is not recommended for surgical management, according to a study published online July 16 in The Spine Journal. http://medicalxpress.com/news/2012-07-curettage-sacral-giant-cell-tumors.html Cancer Wed, 25 Jul 2012 14:20:01 EST news262439921 Researchers at the Center for Laser Applications at the University of Tennessee Space Institute in Tullahoma have developed a technology that goes on a "seek and destroy" mission for cancerous tumors. They have harnessed the power of lasers to find, map and non-invasively destruct cancerous tumors. http://medicalxpress.com/news/2012-07-laser-technology-cancer.html Cancer Mon, 23 Jul 2012 12:38:19 EST news262265876 Nearly a third of adults with the most common type of brain cancer develop recurrent, invasive tumors after being treated with a drug called bevacizumab. The molecular underpinnings behind these detrimental effects have now been published in the July issue of Cancer Cell. The findings reveal a new treatment strategy that could reduce tumor invasiveness and improve survival in these drug-resistant patients. http://medicalxpress.com/news/2012-07-treatment-brain-cancer-revealed-molecular.html Cancer Mon, 09 Jul 2012 12:00:09 EST news261052788 A combination of the prodrug TH-302 and radiation may provide an effective treatment strategy for pancreatic cancer, according to preclinical results presented at the American Association for Cancer Research's Pancreatic Cancer: Progress and Challenges conference, held here June 18-21. http://medicalxpress.com/news/2012-06-combination-th-human-pancreatic-tumor.html Cancer Tue, 19 Jun 2012 15:30:03 EST news259325699 Barcelona, Spain: New findings from a large Danish database of cancer patients suggest that, even though the human papilloma virus (HPV) can trigger throat cancer, patients who are HPV-positive and are light smokers, or don't smoke at all, have a good response to treatment using radiotherapy alone, without the addition of chemotherapy with its consequent toxic side-effects. http://medicalxpress.com/news/2012-05-hpv-positive-throat-cancer-patients-radiotherapy.html Cancer Thu, 10 May 2012 10:28:37 EST news255864482 Scientists at The Scripps Research Institute have shown that an injectable solution can protect mice from an otherwise lethal overdose of cocaine. The findings could lead to human clinical trials of a treatment designed to reverse the effects of cocaine in case of emergency. Cocaine is involved in more than 400,000 emergency-room visits and about 5,000 overdose deaths each year in the United States. http://medicalxpress.com/news/2012-04-antidote-cocaine-overdose-lab.html Medications Wed, 18 Apr 2012 12:29:41 EST news253970959 Developed in Canada and conducted by researchers from the University of Ottawa Heart Institute, in partnership with Spartan Bioscience, the world's first bedside genetic test has received acknowledgment by The Lancet, the world's leading general medical journal. http://medicalxpress.com/news/2012-03-world-bedside-genetic-green-lancet.html Cardiology Thu, 29 Mar 2012 11:21:58 EST news252238889 Patients with a cardiac irregularity and myotonic dystrophy type 1 (a severe neuromuscular disorder with a high risk of sudden death) who received an invasive treatment strategy that included testing of their heart's electrical conduction system and if needed, implantation of a device such as a pacemaker, had an associated higher rate of 9-year survival compared to patients treated noninvasively, according to a study in the March 28 issue of JAMA. http://medicalxpress.com/news/2012-03-invasive-treatment-strategy-survival-patients.html Cardiology Tue, 27 Mar 2012 16:00:05 EST news252082161 There is an imbalance between the rapid growth of cardiac catheterization laboratories, which provide percutaneous coronary intervention (PCI) procedures, relative to the growth in the overall U.S. population, as well as patients who experience an acute heart attack, or ST-elevation myocardial infarction (STEMI), according to a study presented March 25 at the 61st annual American College of Cardiology (ACC) scientific session. http://medicalxpress.com/news/2012-03-significant-mismatch-pci-capable-hospitals.html Cardiology Sun, 25 Mar 2012 14:21:15 EST news251904052 Tissue in monkeys infected with a close relative of HIV can ramp up production of a type of T cell that actually weakens the body's attack against the invading virus. The discovery, in lymph nodes draining the intestinal tract, could help explain how the HIV virus evades the body's immune defenses. http://medicalxpress.com/news/2012-02-siv-infection-immune-suppressive-treg-cells.html Immunology Tue, 14 Feb 2012 13:44:54 EST news248449475 Researchers at Virginia Commonwealth University Medical Center's VCU Massey Cancer Center and Harold F. Young Neurosurgical Center (Richmond, VA) and Old Dominion University (Norfolk, VA) have discovered that suppression of Wilms tumor 1 protein (WT1) results in downregulation of CD97 gene expression in three glioblastoma cell lines and reduces the characteristic invasiveness exhibited by glial tumor cells. This finding is announced in the article, "Novel report of expression and function of CD97 in malignant gliomas: correlation with Wilms tumor 1 expression and glioma cell invasiveness," by Archana Chidambaram, Ph.D., and colleagues, published online ahead of print today in the Journal of Neurosurgery. Although further studies must be performed, the authors propose that CD97 may prove to be a new target for anti-glioma therapies. http://medicalxpress.com/news/2012-02-cd97-gene-function-wt1-protein.html Neuroscience Tue, 07 Feb 2012 10:30:01 EST news247832331 Researchers at Virginia Commonwealth University Massey Cancer Center have developed a novel treatment strategy for multiple myeloma that delivers a deadly one-two blow to kill even the most inactive, or cytokinetically quiescent, cells. Because multiple myeloma can rest in a non-proliferative state for extended periods of time, this discovery may help to overcome a major hurdle to treating this fatal disease.   http://medicalxpress.com/news/2011-11-scientists-defeat-hurdle-eradicating-inactive.html Cancer Mon, 14 Nov 2011 09:37:51 EST news240485863 Higher surgical costs for adult congenital heart patients is associated with higher rates of inpatient death compared to surgical admissions that incur lower costs, according to a study in Circulation: Quality and Outcomes, a journal of the American Heart Association. http://medicalxpress.com/news/2011-10-adult-congenital-heart-patients-highest.html Cardiology Tue, 18 Oct 2011 16:00:03 EST news238155739 Conway Fellow, Professor William Watson and Professor John Fitzpatrick, UCD School of Medicine and Medical Science and Mater Misericordiae University Hospital recently received a translational research award for the validation of a panel of serum biomarkers to inform surgical intervention for prostate cancer. http://medicalxpress.com/news/2011-06-prostate-cancer-biomarkers-closer-clinical.html Cancer Fri, 17 Jun 2011 09:28:15 EST news227521664 Dozens of studies on whether moderate exercise can curb the nicotine cravings of women smokers have added up to an apparent contradiction: it seems to work in short-term, well controlled lab experiments, but then fizzles out in treatment trials. A new study may explain why and help researchers devise a practical therapy. http://medicalxpress.com/news/2011-05-women-cravings-effect-short-lived.html Health Thu, 19 May 2011 10:53:46 EST news225021209 Yervoy is unlikely to win a contest for best named drug, but recent US Food and Drug Administration (FDA) approval for the new entrant in the battle against cancer marks the success of a novel treatment strategy, and is another indicator that immunotherapy has gone mainstream. http://medicalxpress.com/news/2011-05-ucsf-scientists-key-role-success.html Cancer Fri, 06 May 2011 09:52:04 EST news223894307