http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. Sleeping sickness kills tens of thousands of people in Africa each year. Current chemotherapies are subject to various limitations, including resistance. Rhodesain, an enzyme of the parasites that cause this illness (human African trypanosomiasis), has emerged as a target for new drug candidates. Scientists led by F. Diederich (ETH Zürich) studied the molecular recognition properties of rhodesain and developed a series of triazine nitrile inhibitors as lead compounds using structure-based molecular modeling. http://medicalxpress.com/news/2013-05-awakening-drugs-sickness.html Cancer Fri, 17 May 2013 07:54:03 EST news287996023 Wild animals may be a key contributor to the continuing spread of African sleeping sickness, new research published in PLOS Computational Biology shows. The West African form of the disease, also known as Gambiense Human African trypanosomiasis, affects around 10,000 people in Africa every year and is deadly if left untreated. http://medicalxpress.com/news/2013-01-wild-animals-contribute-resurgence-african.html Diseases, Conditions, Syndromes Thu, 17 Jan 2013 17:00:02 EST news277661438 A new oral-only treatment for sleeping sickness has entered Phase II/III clinical study in patients with late-stage sleeping sickness in the Democratic Republic of the Congo (DRC) and soon in Central African Republic (CAR). The study, initiated by the Drugs for Neglected Diseases initiative (DNDi) and its partners, will test the efficacy and safety of fexinidazole, with once-daily tablets for ten days. http://medicalxpress.com/news/2012-12-oral-drug-candidate-african-sickness.html Medications Thu, 06 Dec 2012 03:00:01 EST news273948616 The Drugs for Neglected Diseases initiative (DNDi) and Medicines for Malaria Venture (MMV) announce today the identification of three chemical series targeting the treatment of deadly neglected tropical diseases (NTDs), through DNDi's screening of MMV's open access Malaria Box. The resulting DNDi screening data are among the first data generated on the Malaria Box to be released into the public domain, exemplifying the potential of openly sharing drug development data for neglected patients. http://medicalxpress.com/news/2012-11-access-reveals-drug-deadly-neglected.html Diseases, Conditions, Syndromes Tue, 13 Nov 2012 10:03:06 EST news272023371 Research led by scientists at the London School of Hygiene & Tropical Medicine has exploited a revolutionary genetic technique to discover how human African Trypanosomiasis (HAT) drugs target the parasite which causes the disease. The new knowledge could help lead to the development of better treatments for the tens of thousands of people in sub-Saharan Africa who are affected each year. http://medicalxpress.com/news/2012-01-genetic-technique-treatments-sickness.html Genetics Wed, 25 Jan 2012 13:00:07 EST news246710152 (Medical Xpress) -- The savannahs and rainforests of Africa bring to mind romantic notions of wildlife, adventure and exploration. But beneath this natural beauty lies a deadly, long-neglected disease: trypanosomiasis, otherwise known as African sleeping sickness. http://medicalxpress.com/news/2011-12-african-sickness-tale-parasites.html Diseases, Conditions, Syndromes Thu, 08 Dec 2011 05:54:15 EST news242546025