http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. Scientists invariably conduct debates in private about whether a body of scientific work or thought is worthy of presentation to the community. Behind closed doors scientists and editors tussle over when is the right time to publish their work. In a disruptive departure from this norm, Disruptive Science and Technology, a peer-reviewed journal from Mary Ann Liebert, Inc. publishers, has launched a Debate section in which ideas and counterpoints can be debated in public. The Journal seeks not to sway opinions but rather to inform them. It is fitting that the first series of debates is focused on the root cause of cancer. http://medicalxpress.com/news/2013-01-embracing-debate-cancers-effective-therapies.html Cancer Wed, 16 Jan 2013 12:15:40 EST news277560895 Breast cancer is the second leading cause of cancer deaths among women in the United States. Many of these deaths occur when there is an initial diagnosis of invasive or metastatic disease. A protein called NEDD9—which regulates cell migration, division and survival—has been linked to tumor invasion and metastasis in a variety of cancers. Researchers at Fox Chase Cancer Center have now shown that NEDD9 plays a surprising role in the early stages of breast tumor development by controlling the growth of progenitor cells that give rise to tumors. The findings, published in the journal Oncogene on January 14, 2013, could lead to personalized treatment strategies for women with breast cancer based on the levels of NEDD9 in their tumors. http://medicalxpress.com/news/2013-01-role-nedd9-gene-early-stages.html Cancer Mon, 14 Jan 2013 13:08:36 EST news277391310 Scientists at the University of Arizona Cancer Center and the Moffitt Cancer Center, led by Dr. Robert Gillies, have demonstrated that an advanced magnetic resonance imaging (MRI) method can non-invasively evaluate the cellular proliferation of tumor models of breast cancer. This quantitative imaging method evaluates the diffusion of water in tumor tissue, which correlates with the growth rates of the tumor models. The results, which appear in the November 2012 issue of Experimental Biology and Medicine, can contribute to the development of new tumor models for cancer research. http://medicalxpress.com/news/2012-12-cancer-advanced-biomedical-imaging-method.html Cancer Mon, 17 Dec 2012 12:34:16 EST news274970050 Cell aging, or cellular senescence, has an important role in the natural physiological response to tumor development. Activated oncogenes are able to induce senescence, and recent findings have suggested that oncogene-induced senescence (OIS) could play a key role in future cancer therapy. Researchers have now identified a previously unknown mechanism in the regulation of OIS. This study is published online in advance of the January issue of The American Journal of Pathology. http://medicalxpress.com/news/2012-12-previously-unknown-mechanism-oncogene-induced-senescence.html Cancer Wed, 12 Dec 2012 00:00:02 EST news274462449 One of the most frustrating truths about cancer is that even when a treatment works, it often doesn't work for long because cancer cells find ways to resist. However, researchers reporting studies done in mice in the December 11, 2012, issue of Cancer Cell, a Cell Press publication, may have a way to stay one step ahead in the case of aggressive metastatic breast cancer. http://medicalxpress.com/news/2012-12-incurable-metastatic-breast-cancer-resistance.html Cancer Mon, 10 Dec 2012 12:00:05 EST news274359966 Inflammatory breast cancer (IBC) is a very rare and aggressive disease that progresses rapidly and is associated with a very low survival rate. To understand how this type of cancer spreads, it's crucial to characterize the interactions between cancer cells and their 3D environment. Researchers at Fox Chase Cancer Center have developed a novel, 3D culture system that mimics the environment surrounding these cancer cells. This model could be used to test new anticancer drugs capable of inhibiting the spread of IBC tumors. http://medicalxpress.com/news/2012-12-d-culture-inflammatory-breast-cancer.html Cancer Sun, 09 Dec 2012 02:51:18 EST news274243825 Obese women might be able to eliminate their increased risk for postmenopausal breast cancer by taking measures during perimenopause to prevent weight gain and to therapeutically control the metabolic effects of their obesity, according to the results of a preclinical study published in Cancer Research, a journal of the American Association for Cancer Research. http://medicalxpress.com/news/2012-12-obesity-overeating-menopause-breast-tumor.html Cancer Fri, 07 Dec 2012 11:10:08 EST news274098853 The causes underlying the development of certain types of common cancers have not yet been elucidated. In order to better determine the origin and the sequence of events responsible for the onset of colon cancer, the teams led by Thanos Halazonetis and Stylianos Antonarakis, professors at the University of Geneva (UNIGE), Switzerland, have sequenced the DNA of biopsied tissue from colon polyps. The results show that these precancerous lesions have a specific profile called 'mutator', which is associated with an increased frequency of acquisition of certain mutations. http://medicalxpress.com/news/2012-12-mechanism-colon-polyps.html Cancer Sun, 02 Dec 2012 02:22:43 EST news273637341 Physicians may now be better at detecting breast cancer than ever before, but much more work remains to ensure accurate diagnosis is possible and especially to assess future risk. That's why researchers from Germany have been working to develop a new test of gene action to predict cancer risk both at first diagnosis and into the future. In a new research report appearing in the December 2012 issue of The FASEB Journal, researchers show that the various genetic switches, which are turned on and off in the regular development of every cell in the body, can be analyzed in minute detail to determine the presence or risk of breast cancer growth. http://medicalxpress.com/news/2012-11-genetic-early-breast-cancer-future.html Cancer Thu, 29 Nov 2012 12:48:05 EST news273415675 Researchers at the Universidade Federal in Rio de Janeiro in Brazil have found that introduction of a normal copy of the p53 gene in p53-defective cancer cell lines makes these cells sensitive to the anti-tumor proprieties of resveratrol, the naturally occurring dietary compound found in red wine. http://medicalxpress.com/news/2012-11-resveratrol-full-p53-ingredients-successful.html Medical research Tue, 13 Nov 2012 11:25:45 EST news272028333 A molecule involved in asthma and allergies has now been shown to make mice resistant to skin cancer, according to scientists at Washington University School of Medicine in St. Louis. http://medicalxpress.com/news/2012-10-mice-asthma-allergies-skin-cancer.html Cancer Mon, 15 Oct 2012 12:00:06 EST news269499407 Researchers at the University of California, San Diego School of Medicine report the discovery of microbial–dependent mechanisms through which some cancers mount an inflammatory response that fuels their development and growth. http://medicalxpress.com/news/2012-10-blocking-tumor-induced-inflammation-impacts-cancer.html Cancer Wed, 03 Oct 2012 13:00:13 EST news268487506 Inflammatory bowel disease is caused by chronic inflammation , which leads to damage of the intestinal epithelium. http://medicalxpress.com/news/2012-07-decreasing-cancer-inflammatory-bowel-disease.html Inflammatory disorders Mon, 09 Jul 2012 12:00:06 EST news261052606 A pair of recent studies describes how pancreatic cancer cells produce a protein that attracts the body's immune cells and tricks them into helping cancer cells grow. The research, published by Cell Press in the June 12th issue of the journal Cancer Cell, also reveals that blocking the protein may be an effective way to treat pancreatic cancer. http://medicalxpress.com/news/2012-06-pancreatic-cancer-immune.html Cancer Mon, 11 Jun 2012 12:00:03 EST news258632760 (Medical Xpress) -- Stem cells often used in reconstructive surgery following mastectomies and other cancer-removal treatments may pose a danger: Cornell biomedical scientists have discovered that these cells, in contact with even trace amounts of cancer cells, can create a microenvironment suitable for more tumors to grow. http://medicalxpress.com/news/2012-06-stem-cells-trigger-tumors.html Cancer Tue, 05 Jun 2012 05:46:10 EST news258093894 Four years after they discovered the viral roots of a rare skin cancer, researchers at the University of Pittsburgh Cancer Institute (UPCI) and the School of Medicine have now identified a molecule activated by this virus that, in animal studies, could be targeted to selectively kill the tumor cells. The treatment will soon be tested in patients. http://medicalxpress.com/news/2012-05-genomics-molecular-based-treatment-viral-skin.html Cancer Wed, 09 May 2012 14:00:05 EST news255782721 New research confirms an association between smoking and a reduced risk for a rare benign tumor near the brain, but the addition of smokeless tobacco to the analysis suggests nicotine is not the protective substance. http://medicalxpress.com/news/2012-04-nicotine-rare-tumor.html Cancer Mon, 23 Apr 2012 12:44:11 EST news254403839 A new study describes a therapeutic approach to halting cancer progression by exploiting a previously unrecognized "addiction" of leukemia cells to specific signaling molecules. The research, published by Cell Press online on April 16th in the journal Cancer Cell, identifies non-classical oncogenes critical for tumor development and survival, and describes a potentially less toxic strategy that selectively targets these molecules. http://medicalxpress.com/news/2012-04-therapy-exploits-addiction-leukemia-cells.html Cancer Mon, 16 Apr 2012 13:45:03 EST news253802693 Inflammation, cell division and cell differentiation that occur during skeletal muscle regeneration may provide an ideal environment for the highly malignant tumor, rhabdomyosarcoma to arise. These are the findings from a Nationwide Children's Hospital study that examined rhabdomyosarcoma growth in mouse models of muscular dystrophy. The new models could help investigators search for factors that drive tumor growth and help test new therapies. http://medicalxpress.com/news/2012-02-muscle-regeneration-ideal-environment-rhabdomyosarcoma.html Cancer Wed, 22 Feb 2012 11:52:12 EST news249133922 The University of Kentucky has announced that Dr. Daret St. Clair, the James Graham Brown Endowed Chair and professor of toxicology, has published the first comprehensive study that provides insight into the relationship between two types of suppressors in cancerous tumors. The results will enhance the understanding of transcriptional mechanisms in carcinogenesis. http://medicalxpress.com/news/2012-02-uk-insight-cancer.html Cancer Wed, 22 Feb 2012 11:50:21 EST news249133812 Scientists at Sanford-Burnham Medical Research Institute (Sanford-Burnham) developed a new mouse model for studying a devastating childhood brain cancer called medulloblastoma. The animal model mimics the deadliest of four subtypes of human medulloblastoma, a tumor that is triggered by elevated levels of a gene known as Myc. The study, published February 13 in the journal Cancer Cell, also suggests a potential strategy for inhibiting the growth of this tumor type. This achievement marks an important milestone toward personalized therapies tailored to a specific type of medulloblastoma. http://medicalxpress.com/news/2012-02-childhood-brain-cancer-personalized-treatment.html Cancer Mon, 13 Feb 2012 13:40:01 EST news248362140 The list of aging-associated proteins known to be involved in cancer is growing longer, according to research by investigators at Vanderbilt-Ingram Cancer Center and the National Institutes of Health (NIH). http://medicalxpress.com/news/2011-10-protein-family-key-aging-cancer.html Cancer Mon, 17 Oct 2011 12:21:59 EST news238072906 For the first time, scientists can see pathways to stop a deadly brain cancer in its tracks. Researchers at Case Western Reserve University School of Medicine have imaged individual cancer cells and the routes they travel as the tumor spreads. http://medicalxpress.com/news/2011-08-uncovering-deadly-cancer.html Cancer Fri, 26 Aug 2011 10:38:11 EST news233573873 There might be a time when instead of just drinking that morning cup of coffee you lather it on your skin as a way of preventing harmful sun damage or skin cancer. http://medicalxpress.com/news/2011-08-evidence-caffeine-lowers-skin-cancer.html Cancer Mon, 15 Aug 2011 15:15:56 EST news232640131 Parsley is usually used as a decorative accent to a scrumptious meal, but don't set it aside just yet. In a new study, a University of Missouri researcher has found that a compound in parsley and other plant products, including fruits and nuts, can stop certain breast cancer tumor cells from multiplying and growing. The study was published recently in Cancer Prevention Research. http://medicalxpress.com/news/2011-05-parsley-celery-crucial-component-breast.html Cancer Mon, 09 May 2011 12:30:30 EST news224162997 While incidents of melanoma continue to increase despite the use of sunscreen and skin screenings, a topical compound called ISC-4 may prevent melanoma lesion formation, according to Penn State College of Medicine researchers. http://medicalxpress.com/news/2011-04-topical-treatment-melanoma.html Cancer Tue, 26 Apr 2011 09:40:15 EST news223029593