http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. A team led by Massachusetts General Hospital (MGH) researchers has identified a genetic signature that appears to reflect the risk of tumor recurrence or spread in men surgically treated for prostate cancer. If confirmed in future studies, this finding not only may help determine which patients require additional treatment after the cancerous gland has been removed, it also may help address the most challenging problem in prostate cancer treatment – distinguishing tumors that require aggressive treatment from those that can safely be monitored. The report has been issued online in PNAS Early Edition. http://medicalxpress.com/news/2013-04-gene-expression-signature-signify-recurrence-metastasis.html Cancer Mon, 15 Apr 2013 16:08:58 EST news285260932 (HealthDay)—In patients with hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC), low HCV viral load predicts better long-term surgical outcomes, regardless of the serologic eradication of HCV, according to research published in the Feb. 20 issue of the Journal of Clinical Oncology. http://medicalxpress.com/news/2013-03-long-term-outcomes-hep-viral.html Diseases, Conditions, Syndromes Mon, 25 Mar 2013 12:50:01 EST news283430105 A Kansas State University professor's research on breast cancer stem cells may help improve survival rates by preventing cancer recurrence and metastasis—the major causes of death among breast cancer patients. http://medicalxpress.com/news/2013-02-breast-cancer-treatment-tumor-cells.html Cancer Wed, 13 Feb 2013 11:30:04 EST news279973961 Nearly half of the 700,000 cancer patients who undergo surgical removal of a primary tumor each year suffer a recurrence of their disease at some point, and many of those patients will eventually die from their disease. The traditional view of recurrent tumors is that they are resistant to therapy because they've acquired additional genetic mutations that make them more aggressive and impervious to drugs. Now, however, researchers at the Perelman School of Medicine at the University of Pennsylvania show in an animal model that the enhanced aggressiveness of recurrent tumors may be due to changes in the body's immune response. The findings are published this week in the Proceedings of the National Academy of Sciences. http://medicalxpress.com/news/2012-12-immune-aggressiveness-recurrent-tumors.html Cancer Thu, 27 Dec 2012 12:58:42 EST news275835510 A team of brain cancer researchers at Barrow Neurological Institute at St. Joseph's Hospital and Medical Center has effectively treated brain tumor cells using a unique combination of diet and radiation therapy. The study, "The Ketogenic Diet Is an Effective Adjuvant to Radiation Therapy for the Treatment of Malignant Glioma," was published in PLOS ONE. http://medicalxpress.com/news/2012-12-unique-combination-diet-therapy-successfully.html Cancer Tue, 04 Dec 2012 09:37:52 EST news273836259 (HealthDay)—People with liver cancer tied to infection with the hepatitis B virus who got antiviral therapy after cancer surgery had a lower risk of tumor recurrence than those who did not get it, according to a new study. http://medicalxpress.com/news/2012-11-antiviral-therapy-recurrence-hepatitis-b-linked.html Cancer Mon, 12 Nov 2012 17:30:01 EST news271960674 (Medical Xpress)—In a study to decipher clues about how prostate cancer cells grow and become more aggressive, Johns Hopkins urologists have found that reduction of a specific protein is correlated with the aggressiveness of prostate cancer, acting as a red flag to indicate an increased risk of cancer recurrence. Their findings are reported online in the Proceedings of the National Academy of Sciences on Aug. 27, 2012. http://medicalxpress.com/news/2012-08-team-biological-indicator-aggressive-recurrent.html Cancer Mon, 27 Aug 2012 18:14:37 EST news265310066 Lack of sleep is linked to more aggressive breast cancers, according to new findings published in the August issue of Breast Cancer Research and Treatment by physician-scientists from University Hospitals Case Medical Center's Seidman Cancer Center and Case Comprehensive Cancer Center at Case Western Reserve University. http://medicalxpress.com/news/2012-08-lack-factor-aggressive-breast-cancers.html Cancer Mon, 27 Aug 2012 12:00:11 EST news265287602 (HealthDay)—Accelerated partial breast irradiation (APBI) yields five-year clinical outcomes and patterns of failure similar to those achieved with whole breast irradiation (WBI), with excellent three-year survival for women who develop an ipsilateral breast tumor recurrence (IBTR), according to a study published in the Sept. 1 issue of Cancer. http://medicalxpress.com/news/2012-08-outcomes-similar-partial-breast-irradiation.html Cancer Fri, 24 Aug 2012 14:10:01 EST news265033685 A Rhode Island Hospital radiation oncologist says in a new editorial that research exploring the impact of radiotherapy in older women with low risk of breast cancer recurrence has little effect on actual clinical decisions. The editorial written by David E. Wazer, M.D., chief of the department of radiation oncology, is published in the current issue of the Journal of Clinical Oncology. http://medicalxpress.com/news/2012-08-older-women-benefit-radiotherapy-breast.html Cancer Tue, 21 Aug 2012 11:49:46 EST news264768580 A combination of the prodrug TH-302 and radiation may provide an effective treatment strategy for pancreatic cancer, according to preclinical results presented at the American Association for Cancer Research's Pancreatic Cancer: Progress and Challenges conference, held here June 18-21. http://medicalxpress.com/news/2012-06-combination-th-human-pancreatic-tumor.html Cancer Tue, 19 Jun 2012 15:30:03 EST news259325699 New research from the University of Wisconsin-Madison explains why the incurable brain cancer, glioblastoma multiforme (GBM), is highly resistant to current chemotherapies. http://medicalxpress.com/news/2012-06-team-reveals-drug-resistant-brain-tumor.html Cancer Fri, 01 Jun 2012 19:24:05 EST news257797413 Accelerated partial breast irradiation (APBI) brachytherapy, the localized form of radiation therapy growing increasingly popular as a treatment choice for women with early-stage breast cancer, is associated with higher rate of later mastectomy, increased radiation-related toxicities and post-operative complications, compared to traditional whole breast irradiation (WBI), according to researchers from The University of Texas MD Anderson Cancer Center. http://medicalxpress.com/news/2012-05-apbi-mastectomies-toxicities-complications-traditional.html Cancer Tue, 01 May 2012 16:50:01 EST news255108634 Abdominal tumors involving both roots of the celiac and superior mesenteric artery (SMA) are deemed unresectable by conventional surgical methods, as removal would cause necrosis of the organs that are supplied by those blood vessels. http://medicalxpress.com/news/2012-05-surgical-technique-inoperable-tumors-abdomen.html Surgery Tue, 01 May 2012 15:00:02 EST news255101211 Negative surgical margins should be attained for ductal carcinoma in situ (DCIS) patients after breast-conserving surgery (BCS) regardless of radiotherapy, and surgeons should attempt to reach wide negative margins in their first attempt within cosmetic restraint according to a study published March 22 in the Journal of the National Cancer Institute. http://medicalxpress.com/news/2012-03-margin-threshold-women-ductal-carcinoma.html Cancer Thu, 22 Mar 2012 16:00:01 EST news251637087 Researchers at the Kimmel Cancer Center at Jefferson have demonstrated for the first time that the metabolic biomarker MCT4 directly links clinical outcomes with a new model of tumor metabolism that has patients "feeding" their cancer cells. Their findings were published online March 15 in Cell Cycle. http://medicalxpress.com/news/2012-03-cancer-paradigm-shift-biomarker-links.html Cancer Thu, 15 Mar 2012 17:33:38 EST news251051606 Even though a large clinical study demonstrated that radiation has limited benefit in treating breast cancer in some older women, there was little change in the use of radiation among older women in the Medicare program, Yale School of Medicine researchers report in the March Journal of Clinical Oncology. http://medicalxpress.com/news/2012-03-evidence-benefit-older-breast-cancer.html Cancer Mon, 05 Mar 2012 16:00:03 EST news250167131 Imaging amino acid transporters with positron emission tomography/computed tomography (PET/CT) has been shown to significantly alter intended management plans for patients with brain tumors, according to research in the March issue of The Journal of Nuclear Medicine. As a result of imaging with the radiopharmaceutical 3,4-dihydroxy-6-F-18-fluoro-L-phenylalanine (F-18-DOPA), physicians changed the intended management plan for 41 percent of patients with brain tumors. http://medicalxpress.com/news/2012-03-pet-tracer-brain-tumor-patients.html Cancer Thu, 01 Mar 2012 11:00:02 EST news249821026 Breast cancer stem cells are thought to be the sole source of tumor recurrence and are known to be resistant to radiation therapy and don't respond well to chemotherapy. http://medicalxpress.com/news/2012-02-treatment-breast-cancer-cells-stem.html Cancer Mon, 13 Feb 2012 17:25:12 EST news248375690 Cancer treatments designed to block the growth of blood vessels were found to increase the number of cancer stem cells in breast tumors in mice, suggesting a possible explanation for why these drugs don't lead to longer survival, according to a new study by researchers at the University of Michigan Comprehensive Cancer Center. http://medicalxpress.com/news/2012-01-avastin-sutent-breast-cancer-stem.html Cancer Wed, 25 Jan 2012 09:31:17 EST news246706261 Accelerated partial breast irradiation (APBI) brachytherapy, the localized form of radiation therapy growing increasingly popular as a treatment choice for women with early-stage breast cancer, is associated with higher rate of later mastectomy, increased radiation-related toxicities and post-operative complications, compared to traditional whole breast irradiation (WBI), according to researchers from The University of Texas MD Anderson Cancer Center. http://medicalxpress.com/news/2011-12-side-effects-complications-mastectomy-partial.html Cancer Wed, 07 Dec 2011 05:00:01 EST news242454425 Researchers at Children's Hospital Boston have found a marker called ABCB5 that both tags a small proportion of cells within colorectal cancers and fuels resistance in those cells to standard treatments. The results indicate that eliminating ABCB5-expressing cells is crucial for successful colorectal cancer treatment, while adding to the growing body of evidence for a theory of cancer growth called the cancer stem cell hypothesis. http://medicalxpress.com/news/2011-06-cellular-root-colorectal-cancers.html Cancer Wed, 08 Jun 2011 10:49:58 EST news226748977 Colorectal cancer patients with defects in mismatch repair--one of the body's systems for repairing DNA damage--have lower recurrence rates and better survival rates than patients without such defects, according to a study published online May 19th in the Journal of the National Cancer Institute. http://medicalxpress.com/news/2011-05-dna-affects-colon-cancer-recurrence.html Cancer Thu, 19 May 2011 16:23:38 EST news225040984