http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. Tumor suppression, the family business of the sibling genes p53, p63 and p73, is undermined from within by the split personalities of p63 and p73, which each produce protein forms that not only block the work of the other two genes but also shut down its own cancer-stifling fraternal twin. http://medicalxpress.com/news/2013-04-key-back-up-tumor-fighter-p53.html Cancer Mon, 08 Apr 2013 15:00:01 EST news284644382 (Medical Xpress)—Healthy cells don't just happen. As they grow and divide, they need checks and balances to ensure they function properly while adapting to changing conditions around them. http://medicalxpress.com/news/2013-04-mitochondrial-metabolic-sirt4-dna.html Cancer Fri, 05 Apr 2013 06:21:59 EST news284361702 A compound that stimulates the production of a tumor-fighting protein may improve the usefulness of the protein in cancer therapy, according to a team of researchers. http://medicalxpress.com/news/2013-02-compound-tumor-fighting-protein-cancer-therapy.html Cancer Wed, 06 Feb 2013 15:19:06 EST news279386339 Research led by Dr. Suresh Alahari, the Fred Brazda Professor of Biochemistry and Molecular Biology at LSU Health Sciences Center New Orleans and its Stanley S. Scott Cancer Center, details exactly how the Her2 cancer gene promotes the progression and spread of breast cancer cells. The inactivation of a tumor suppression gene called Nischarin is among the mechanisms identified. The findings provide a new therapeutic target to block the function of Her2. The research was published in Cancer Research, OnlineFirst on January 21, 2013. http://medicalxpress.com/news/2013-01-drug-her-breast-cancer.html Cancer Tue, 22 Jan 2013 13:12:49 EST news278082689 Newly published research by Indiana University structural biologist Joel Ybe and colleagues identifies a "topology switch" in the protein clathrin, the function of which may shed light on molecular processes involved in tumor suppression. http://medicalxpress.com/news/2013-01-molecular-role-tumor-suppression.html Cancer Sun, 13 Jan 2013 06:57:54 EST news277282660 Lung cancer researchers at St. Joseph's Hospital and Medical Center in Phoenix, Ariz., in collaboration with researchers at the Translational Genomics Research Institute and other institutions, have identified a gene that plays a role in the growth and spread of non-small cell lung cancer tumors, opening the door for potential new treatment options. http://medicalxpress.com/news/2012-11-gene-involved-lung-tumor-growth.html Cancer Thu, 29 Nov 2012 16:43:03 EST news273429766 Researchers at Moffitt Cancer Center and colleagues have identified PHF20, a novel transcriptional factor, and clarified its role in maintaining the stability and transcription of p53, a gene that allows for both normal cell growth and tumor suppression. PHF20, the researchers found, plays a previously unknown and unique role in regulating p53. http://medicalxpress.com/news/2012-08-colleagues-phf20-gene-p53.html Cancer Fri, 24 Aug 2012 00:25:02 EST news264986692 Scientists investigating the interactions, or binding patterns, of a major tumor-suppressor protein known as p53 with the entire genome in normal human cells have turned up key differences from those observed in cancer cells. The distinct binding patterns reflect differences in the chromatin (the way DNA is packed with proteins), which may be important for understanding the function of the tumor suppressor protein in cancer cells. The study was conducted by scientists at the U.S. Department of Energy's (DOE) Brookhaven National Laboratory and collaborators at Cold Spring Harbor Laboratory, and is published in the December 15 issue of the journal Cell Cycle. http://medicalxpress.com/news/2011-11-analysis-tumor-suppressor-interactions-genome-human.html Cancer Wed, 30 Nov 2011 10:30:02 EST news241867703 Mice born to mothers who are fed a diet supplemented with B vitamins are less likely to develop intestinal tumors, report scientists at the Jean Mayer USDA Human Nutrition Research Center on Aging (USDA HNRCA) at Tufts University. http://medicalxpress.com/news/2011-06-vitamins-mother-diet-colorectal-cancer.html Health Thu, 09 Jun 2011 11:23:05 EST news226837362 New research from North Carolina State University shows that a "gatekeeper" protein plays an important role in skin-cancer prevention in humans and lab mice. http://medicalxpress.com/news/2011-05-lack-gatekeeper-protein-linked-skin.html Cancer Wed, 18 May 2011 11:08:31 EST news224935690 Dana-Farber Cancer Institute scientists have discovered new details of how cancer cells escape from tumor suppression mechanisms that normally prevent these damaged cells from multiplying. They also demonstrated a potential link between this cell proliferation control mechanism and the cognitive deficits caused by Down syndrome. http://medicalxpress.com/news/2011-04-key-players-cancer-cells-survival.html Medical research Tue, 26 Apr 2011 13:08:59 EST news223042122