http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. Researchers at Moffitt Cancer Center say identifying and selecting participants for phase II cancer clinical trials from a centralized warehouse of patient-donated biological data expedites participant accrual, reduces trial size, saves money, and may speed test drugs through the drug development pipeline. http://medicalxpress.com/news/2013-05-cancer-biorepository-clinical-trials-drug.html Cancer Wed, 08 May 2013 04:28:56 EST news287206049 Microbubbles decrease the time and acoustic power of ultrasound required to heat and destroy an embedded target, finds research in BioMed Central's open access journal Journal of Therapeutic Ultrasound. If these results can be replicated in the clinic, microbubbles could improve the efficiency of high intensity ultrasound treatment of solid tumors. http://medicalxpress.com/news/2013-04-microbubbles-cancer-therapy.html Cancer Wed, 24 Apr 2013 20:00:01 EST news286045072 When the eye cancer retinoblastoma is diagnosed in racial and ethnic minority children whose families don't have private health insurance, it often takes a more invasive, potentially life-threatening course than in other children, probably because of delays in diagnosis, Dana-Farber/Children's Hospital Cancer Center (DF/CHCC) researchers will report at the 26th annual meeting of the American Society of Pediatric Hematology Oncology being held in Miami, April 24-27. http://medicalxpress.com/news/2013-04-diagnosis-worsen-outlook-minority-uninsured.html Cancer Wed, 24 Apr 2013 13:30:01 EST news286025989 A new minimally invasive tumor ablation technique is providing hope for liver cancer patients who can't undergo surgery or thermal ablation, a study shows. http://medicalxpress.com/news/2013-04-ablation-technique-liver-cancer-patients.html Cancer Thu, 18 Apr 2013 00:00:04 EST news285436299 Diagnosis of the brain cancer glioblastoma multiforme (GBM) is particularly bad news for patients due to limited available medical options and poor outcomes. Even treatments that can eliminate other malignancies, such as chemotherapy and surgery, buy only limited time for GBM patients. http://medicalxpress.com/news/2013-04-insights-abnormally-rna-molecule-yield.html Cancer Wed, 10 Apr 2013 10:00:02 EST news284804576 The BRAF mutation believed to drive disease in about half of patients with melanoma was found to occur at a significantly lower frequency in patients with melanoma in Ireland, according to data presented at the AACR Annual Meeting 2013, held in Washington, D.C., April 6-10. http://medicalxpress.com/news/2013-04-braf-mutation-common-patients-melanoma.html Cancer Mon, 08 Apr 2013 08:37:22 EST news284628983 Not all head and neck squamous cell carcinomas (HNSCCs) have the same pattern of genomic alterations, but those cancers with certain distinctive patterns could be amenable to specific targeted therapies, according to a researcher who presented the data at the AACR Annual Meeting 2013, held in Washington, D.C., April 6-10. http://medicalxpress.com/news/2013-04-comprehensive-genomic-analysis-neck-cancer.html Cancer Mon, 08 Apr 2013 08:31:52 EST news284628704 As many as three quarters of advanced ovarian cancer patients appeared to respond to a new two-step immunotherapy approach—including one patient who achieved complete remission—according research from the Perelman School of Medicine at the University of Pennsylvania that will be presented today in a press conference at the AACR Annual Meeting 2013. http://medicalxpress.com/news/2013-04-two-step-ovarian-cancer-immunotherapy-patients.html Cancer Sat, 06 Apr 2013 14:38:14 EST news284477887 The first-in-human study of the NeuroBlate Thermal Therapy System finds that it appears to provide a new, safe and minimally invasive procedure for treating recurrent glioblastoma (GBM), a malignant type of brain tumor. The study, which appears April 5 in the Journal of Neurosurgery online, was written by lead author Andrew Sloan, MD, Director of Brain Tumor and Neuro-Oncology Center at University Hospitals (UH) Case Medical Center and Case Comprehensive Cancer Center, who also served as co-Principal Investigator, as well as Principal Investigator Gene Barnett, MD, Director of the Brain Tumor and Neuro-Oncology Center at Cleveland Clinic and Case Comprehensive Cancer Center, and colleagues from UH, Cleveland Clinic, Cleveland Clinic Florida, University of Manitoba and Case Western Reserve University. http://medicalxpress.com/news/2013-04-minimally-invasive-mri-guided-laser-treatment.html Surgery Fri, 05 Apr 2013 10:00:01 EST news284369832 Although a large majority of head and neck cancers have a deregulation of the PI3K/AKT/mTOR pathway, data recently published in Cancer Research, a journal of the American Association for Cancer Research, indicated that deregulation of this pathway does not necessarily signify that the tumor is dependent on it for survival and progression. http://medicalxpress.com/news/2013-01-common-genetic-neck-cancers-key.html Cancer Tue, 29 Jan 2013 13:00:01 EST news278676552 Cancer researchers are increasingly aware that in addition to genetic mutations in a cancer itself, characteristics of the surrounding tissue can promote or suppress tumor growth. One of these important tissue characteristics is inflammation – most cancers prosper in and attach to inflamed tissue and so many cancers have developed ways to create it. http://medicalxpress.com/news/2013-01-body-ibuprofen-sparc-inflammation-bladder.html Cancer Wed, 16 Jan 2013 12:00:01 EST news277556125 Genetic sequencing technology is altering the way cancer is diagnosed and treated, but traditional specimen handling methods threaten to slow that progress. http://medicalxpress.com/news/2013-01-scripps-physicians-cancer-tissue.html Cancer Fri, 04 Jan 2013 13:09:32 EST news276527366 Physicians may now be better at detecting breast cancer than ever before, but much more work remains to ensure accurate diagnosis is possible and especially to assess future risk. That's why researchers from Germany have been working to develop a new test of gene action to predict cancer risk both at first diagnosis and into the future. In a new research report appearing in the December 2012 issue of The FASEB Journal, researchers show that the various genetic switches, which are turned on and off in the regular development of every cell in the body, can be analyzed in minute detail to determine the presence or risk of breast cancer growth. http://medicalxpress.com/news/2012-11-genetic-early-breast-cancer-future.html Cancer Thu, 29 Nov 2012 12:48:05 EST news273415675 Using advanced microscopes equipped with tissue-penetrating laser light, cancer imaging experts at Johns Hopkins have developed a promising, new way to accurately analyze the distinctive patterns of ultra-thin collagen fibers in breast tumor tissue samples and to help tell if the cancer has spread. http://medicalxpress.com/news/2012-11-laser-light-breast-tumor-fiber-patterns.html Cancer Thu, 01 Nov 2012 14:30:15 EST news270999007 When surgeons operate to remove a tumor, determining exactly where to cut can be tricky. Ideally, the entire tumor should be removed while leaving a continuous layer of healthy tissue, but current techniques for locating the tumors during surgery are imprecise. Now a multidisciplinary team from the University of California, San Diego, is developing an alternate means of precisely tagging breast cancer tumors for removal or targeted destruction. They will present the results of their investigations at the AVS 59th International Symposium and Exhibition, held Oct. 28 – Nov. 2 in Tampa, Fla. http://medicalxpress.com/news/2012-10-ultrasound-guided-surgery-breast-cancer-treatment.html Surgery Fri, 26 Oct 2012 16:10:02 EST news270486039 Men who had high levels of the activated Stat5 protein in their prostate cancer after a radical prostatectomy were more likely to have a recurrence or die from the disease compared to men who had little to no presence of the growth protein, according to a recent study published in Human Pathology by Jefferson's Kimmel Cancer Center researchers. http://medicalxpress.com/news/2012-10-stat5-outcomes-prostate-cancer-patients.html Cancer Tue, 16 Oct 2012 12:54:27 EST news269610859 Some animal models developed by researchers at the Institute of Biomedical Research of Bellvitge (IDIBELL) and the Catalan Institute of Oncology (ICO) has served to validate the effectiveness of a new drug against ovarian cancer resistant to cisplatin. The multidisciplinary work, done in collaboration with the biopharmaceutical company Pharmamar, was published in the journal Clinical Cancer Research. http://medicalxpress.com/news/2012-10-animal-revolutionize-cancer.html Cancer Tue, 09 Oct 2012 15:42:54 EST news269016113 Researchers validated a method of noninvasive imaging that provides valuable information about interstitial fluid pressure of solid tumors and may aid in the identification of aggressive tumors, according to the results of a study published in Cancer Research, a journal of the American Association for Cancer Research. http://medicalxpress.com/news/2012-10-noninvasive-enables-ifp-potential-biomarker.html Cancer Mon, 01 Oct 2012 02:31:58 EST news268277502 Not all head and neck cancers are created equal. Those started by infection with the human papillomavirus are less often fatal than those with other causes, such as smoking. Detection of a reliable fingerprint for HPV could help patients avoid unnecessarily harsh treatment. A new study finds that while one popular biomarker for HPV is not a reliable predictor of mortality from the cancers alone, combinations of some biomarkers showed much more promise. http://medicalxpress.com/news/2012-09-hpv-biomarkers-neck-cancers-combinations.html Cancer Tue, 18 Sep 2012 13:00:01 EST news267187425 (Medical Xpress)—Researchers at the National Institutes of Health have discovered a genetic mutation that appears to increase production of red blood cells in tumors. The discovery, based on analysis of tissue from rare endocrine tumors, may help clarify how some tumors generate a new blood supply to sustain their growth, the researchers explained. http://medicalxpress.com/news/2012-09-rare-cancers-yield-potential-source.html Cancer Tue, 18 Sep 2012 07:46:03 EST news267173152 A new probe developed collaboratively at Norris Cotton Cancer Center and Dartmouth College's Thayer School of Engineering uses an innovative fluorescence-reading technology to help brain surgeons distinguish cancerous tissue from normal tissue. The probe tool, now already in use at the Cancer Center for brain surgery, may one day be used for surgeries for a variety of cancers. http://medicalxpress.com/news/2012-07-probe-vital-brain-cancer-surgery.html Cancer Tue, 24 Jul 2012 15:24:17 EST news262362251 A hormone-depleting drug approved last year for the treatment of metastatic prostate cancer can help eliminate or nearly eliminate tumors in many patients with aggressive cancers that have yet to spread beyond the prostate, according to a clinical study to be presented at the annual meeting of the American Society of Clinical Oncology (ASCO), June 1-5, in Chicago. http://medicalxpress.com/news/2012-05-hormone-depleting-drug-localized-high-risk-prostate.html Cancer Wed, 16 May 2012 18:00:05 EST news256405573 New results presented at 3rd European Lung Cancer Conference in Geneva, Switzerland show important steps being made to improve the diagnosis and treatment of malignant pleural mesothelioma, an aggressive cancer of the outer lining of the lungs caused by asbestos exposure. http://medicalxpress.com/news/2012-04-early-diagnosis-treatment-mesothelioma.html Cancer Wed, 18 Apr 2012 11:16:31 EST news253966584 A team of researchers at Duke University has determined the structure of a key molecule that can carry chemotherapy and anti-viral drugs into cells, which could help to create more effective drugs with fewer effects to healthy tissue. http://medicalxpress.com/news/2012-03-discovery-chemo-side-effects.html Cancer Sun, 11 Mar 2012 14:00:15 EST news250690765 Ben Stanger, MD, PhD, assistant professor of Medicine in the Division of Gastroenterology at the Perelman School of Medicine, University of Pennsylvania, and Andrew Rhim, MD, a Gastroenterology Fellow in the Stanger lab, discovered that pancreatic cancer cells in an animal model begin to spread before clinically obvious tumor tissue is detected. What's more, they showed that inflammation enhances cancer progression in part by facilitating a cellular transformation that leads to entry of cancer cells into the circulation. They report their findings this week in Cell. http://medicalxpress.com/news/2012-01-metastasis-pancreatic-cancer-action.html Cancer Thu, 19 Jan 2012 12:49:52 EST news246199703 Researchers from UNC Lineberger Comprehensive Cancer Center are part of a team that has identified a protein, called P-Rex1, that is key to the movement of cells called melanoblasts. When these cells experience uncontrolled growth, melanoma develops. http://medicalxpress.com/news/2011-11-p-rex-protein-key-melanoma.html Cancer Tue, 22 Nov 2011 11:21:16 EST news241183271 Researchers from Huntsman Cancer Institute (HCI) at the University of Utah have discovered a new way to model human breast cancer that could lead to new tools for predicting which breast cancers will spread and new ways to test drugs that may stop its spread. Their results are published online today in the journal Nature Medicine. http://medicalxpress.com/news/2011-10-breast-cancer-discovery-probability-metastasis.html Cancer Sun, 23 Oct 2011 13:25:39 EST news238595129 Research led by Dr. Suresh Alahari, the Fred Brazda Professor of Biochemistry and Molecular Biology at LSU Health Sciences Center New Orleans and its Stanley S. Scott Cancer Center, has found that a protein discovered by his laboratory can inhibit the growth of breast cancer cells. The research will be published September 14, 2011 online in the Journal of the National Cancer Institute. http://medicalxpress.com/news/2011-09-protein-suppress-breast-cancer-growth.html Cancer Wed, 14 Sep 2011 16:30:53 EST news235236613 A non-invasive PET imaging technique may identify lung cancers that respond best to tyrosine kinase inhibitors (TKIs), allowing doctors to better select patients for personalized therapy, according to research presented at the 14th World Conference on Lung Cancer in Amsterdam, hosted by the International Association for the Study of Lung Cancer (IASLC). http://medicalxpress.com/news/2011-07-pet-scan-11cerlotinib-noninvasive-method.html Cancer Tue, 05 Jul 2011 04:49:28 EST news229060128