http://medicalxpress.com/ en-us Medical Xpress internet news portal provides the latest news on Health and Medicine. The fixed combination of the drugs saxagliptin and metformin (Komboglyze) has been approved in Germany since November 2011 for the treatment of type 2 diabetes mellitus. In an early benefit assessment pursuant to the "Act on the Reform of the Market for Medicinal Products" (AMNOG), the German Institute for Quality and Efficiency in Health Care (IQWiG) examined whether this fixed combination product offers an added benefit versus the current standard treatment. Such an added benefit cannot be derived from the dossier, however, as the manufacturer did not submit any relevant data. http://medicalxpress.com/news/2013-04-added-benefit-saxagliptinmetformin-combination-proven.html Medications Mon, 29 Apr 2013 12:53:38 EST news286458812 A new scoring system takes a holistic view of the effect of obesity treatment in patients. http://medicalxpress.com/news/2013-04-holistic-scoring-obesity-treatment-outcomes.html Overweight and Obesity Tue, 23 Apr 2013 10:10:01 EST news285929241 According to a study published in the Journals of Gerontology Series A: Biological Sciences and Medical Sciences, a baseline adherence to a Mediterranean diet (MeDiet) is associated with a lower risk of hyperuricemia, defined as a serum uric acid (SUA) concentration higher than 7mg/dl in men and higher than 6mg/dl in women. http://medicalxpress.com/news/2013-04-experts-mediterranean-diet-health-effects.html Health Thu, 18 Apr 2013 12:48:59 EST news285508132 (HealthDay)—Weight gain is higher in patients with type 2 diabetes mellitus (T2DM) who receive more intensive glycemic control treatment and is associated with a reduction of A1C from baseline, according to research published online Feb. 14 in Diabetes Care. http://medicalxpress.com/news/2013-03-intensive-glycemic-linked-highest-weight.html Diabetes Thu, 21 Mar 2013 11:30:03 EST news283083370 (HealthDay)—For people with type 2 diabetes mellitus (T2DM), a nine-month aerobic and resistance training program significantly improves quality of life (QOL) compared with no exercise, according to research published online Feb. 12 in Diabetes Care. http://medicalxpress.com/news/2013-03-quality-life-diabetes.html Diabetes Tue, 19 Mar 2013 05:20:01 EST news282887693 (HealthDay)—For women with gestational diabetes mellitus (GDM), clinical and genetic factors including higher pre-pregnancy body mass index are associated with development of type 2 diabetes mellitus (T2DM), according to a study published online March 7 in the Journal of Clinical Endocrinology. http://medicalxpress.com/news/2013-03-key-variables-gestational-diabetes-advance.html Diabetes Mon, 18 Mar 2013 15:10:01 EST news282833900 Preliminary evidence from a clinical trial suggests that treatment with glucagon-like peptide-1 (GLP-1) receptor agonists was associated with reduced body mass index and body weight in adolescents with severe obesity, according to a report published Online First by JAMA Pediatrics. http://medicalxpress.com/news/2013-02-glucagon-like-peptide-receptor-agonists-adolescent.html Pediatrics Mon, 04 Feb 2013 16:00:12 EST news279197910 (HealthDay)—Circulating levels of the Wnt/β-catenin signaling inhibitor sclerostin are higher in patients with type 2 diabetes who also have atherosclerotic disease, according to a study published online Jan. 3 in Diabetes Care. http://medicalxpress.com/news/2013-01-sclerostin-linked-vascular-disease-diabetes.html Diabetes Mon, 28 Jan 2013 14:20:01 EST news278599736 (HealthDay)—In addition to traditional cardiovascular disease risk factors, in patients with type 2 diabetes, coronary artery calcium (CAC) predicts the risk of cardiovascular death, according to a study published online Dec. 10 in Diabetes Care. http://medicalxpress.com/news/2013-01-coronary-artery-calcium-cardio-death.html Diabetes Fri, 18 Jan 2013 13:00:56 EST news277736450 Researchers have found new evidence that metabolic stress can increase the onset of atrial arrhythmias, such as atrial fibrillation (AF), a common heart condition that causes an irregular and often abnormally fast heart rate. The findings may pave the way for the development of new therapies for the condition which can be expected to affect almost one in four of the UK population at some point in their lifetime. http://medicalxpress.com/news/2013-01-common-heart-condition.html Cardiology Tue, 08 Jan 2013 09:17:14 EST news276859023 Patients with obstructive sleep apnea have the same early cardiovascular damage as diabetics, according to research presented at EUROECHO and other Imaging Modalities 2012. The study1 was presented by Dr Raluca Mincu from Bucharest, Romania. http://medicalxpress.com/news/2012-12-deadly-heart-failure.html Sleep apnea Wed, 05 Dec 2012 04:47:20 EST news273905231 (HealthDay)—For patients with type 2 diabetes mellitus (T2DM), classification as normal weight or obese within a year of initial diabetes diagnosis correlates with significantly higher mortality, forming a U-shaped association between body mass index (BMI) and mortality, according to a study published online Nov. 8 in Diabetes Care. http://medicalxpress.com/news/2012-11-u-shaped-link-bmi-diagnosis-mortality.html Diabetes Fri, 16 Nov 2012 16:30:01 EST news272301766 Between 600,000 and 800,000 Austrians have diabetes mellitus. This "sugar disease", as it is known, can itself already be treated very effectively. The later consequences of diabetes, however, which mostly affect the blood vessels and cause cardiovascular conditions such as myocardial infarctions or strokes, are more likely to be fatal. Diabetes expert Michael Resl from the University Department of Internal Medicine III at the MedUni Vienna, on the occasion of World Diabetes Day on 14th November, is keen to draw people's attention to this threat. http://medicalxpress.com/news/2012-11-diabetes-mellitus-life-threatening-late-complications.html Diabetes Wed, 14 Nov 2012 08:30:03 EST news272103165 Eating more legumes (such as beans, chickpeas or lentils) as part of a low-glycemic index diet appears to improve glycemic control and reduce estimated coronary heart disease (CHD) risk in patients with type 2 diabetes mellitus (DM), according to a report of a randomized controlled trial published Online First by Archives of Internal Medicine. http://medicalxpress.com/news/2012-10-legumes-glycemic-heart-disease.html Health Mon, 22 Oct 2012 16:00:15 EST news270136926 (HealthDay)—Intensive lifestyle intervention for weight loss (ILI) significantly improves high-density lipoprotein cholesterol (HDL-C) levels in overweight and obese individuals with type 2 diabetes, which is partially mediated by stimulation of adiponectin production, according to a study published online Sept. 5 in the Journal of Lipid Research. http://medicalxpress.com/news/2012-10-adiponectin-hdl.html Medical research Thu, 18 Oct 2012 14:50:01 EST news269789968 (Medical Xpress)—Research shows that managing and treating vascular disease risk factors are not only beneficial to preventing heart disease and stroke, but also common forms of dementia. http://medicalxpress.com/news/2012-10-outlining-factors-dementia.html Alzheimer's disease & dementia Tue, 16 Oct 2012 08:09:30 EST news269593759 (HealthDay)—Even within an integrated Veterans Affairs (VA) system with a uniform national formulary and established criteria for drug use, there is substantial variation in the use of thiazolidinediones and long-acting insulin analogues among veterans with type 2 diabetes mellitus (T2DM), according to a research letter published online Oct. 8 in the Archives of Internal Medicine. http://medicalxpress.com/news/2012-10-costly-diabetes-medications-varies-widely.html Diabetes Fri, 12 Oct 2012 11:00:04 EST news269256871 One of life's certainties is that everyone ages. However, it's also certain that not everyone ages at the same rate. According to recent research being presented this week, the cardiovascular system of people with type 2 diabetes shows signs of aging significantly earlier than those without the disease. However, exercise can help to slow down this premature aging, bringing the aging of type 2 diabetes patients' cardiovascular systems closer to that of people without the disease, says researcher Amy Huebschmann of the University of Colorado School of Medicine. She will be presenting these findings she developed with colleagues Wendy Kohrt and Judith Regensteiner, both from the same institution. http://medicalxpress.com/news/2012-10-incorporating-regular-physical-diabetic-adults.html Diabetes Thu, 11 Oct 2012 08:10:01 EST news269160908 (HealthDay)—There is an inverse relationship between hip circumference and risk of type 2 diabetes mellitus (T2DM), according to a meta-analysis published online Sept. 3 in Obesity Reviews. http://medicalxpress.com/news/2012-09-hip-circumference-inversely-tied-diabetes.html Overweight and Obesity Tue, 18 Sep 2012 14:00:02 EST news267192684 Obese adults with excess visceral fat (fat located inside the abdominal cavity, around the body's internal organs) and biomarkers of insulin resistance had an associated increased risk for the development of type 2 diabetes mellitus, while obese individuals with higher amounts of total body fat and subcutaneous fat (underneath the skin) did not have this increased risk, according to a study in the September 19 issue of JAMA, and theme issue on obesity. http://medicalxpress.com/news/2012-09-obese-adults-excess-abdominal-fat.html Diabetes Tue, 18 Sep 2012 11:04:00 EST news267185033 (HealthDay) -- Among patients with pancreatic adenocarcinoma (PAC), those with pre-existing type 2 diabetes mellitus (T2DM) for longer than five years have an increased mortality risk, according to a study published online Aug. 1 in Cancer. http://medicalxpress.com/news/2012-08-long-term-diabetes-ups-pancreatic-cancer.html Cancer Wed, 15 Aug 2012 14:27:15 EST news264259581 (HealthDay) -- Patients with type 2 diabetes mellitus (T2DM) have reduced functional connectivity in the default mode network, which is associated with insulin resistance in some brain regions, according to a study published online July 26 in Diabetes. http://medicalxpress.com/news/2012-08-brain-diabetes.html Diabetes Wed, 01 Aug 2012 18:00:02 EST news263057867 (HealthDay) -- There were both good and bad trends in the overall health of Americans in 2011, a new government report shows. http://medicalxpress.com/news/2012-06-health-americans-bag-cdc.html Health Tue, 19 Jun 2012 09:56:51 EST news259318580 Obstructive sleep apnea (OSA) is independently associated with diabetic peripheral neuropathy (DPN) in patients with type 2 diabetes mellitus (T2DM), according to a new study from researchers in the UK. The severity of DPN is also correlated with the degree of OSA and the severity of nocturnal hypoxemia. http://medicalxpress.com/news/2012-06-obstructive-apnea-diabetic-peripheral-neuropathy.html Sleep apnea Fri, 15 Jun 2012 00:20:01 EST news258913792 Research led by the University of Leicester concludes that people newly diagnosed with Type 2 diabetes need ongoing advice from GPs sustained over a number of years rather than a one-off session when they are first diagnosed. http://medicalxpress.com/news/2012-06-people-diabetes-require-ongoing-sustained.html Diabetes Wed, 13 Jun 2012 10:25:58 EST news258801947 A review of data from seven clinical trials suggests that intensive glucose control is associated with reduced risk of microalbuminuria and macroalbuminuria (conditions characterized by excessive levels of protein in the urine usually resulting from damage to the filtering units of the kidneys), according to a report published in the May 28 issue of Archives of Internal Medicine, a JAMA Network publication. http://medicalxpress.com/news/2012-05-aggressively-glucose-kidney-failure-diabetes.html Diabetes Mon, 28 May 2012 16:00:29 EST news257416064 The severity of sleep disordered breathing and nocturnal hypoxemia independently predict both glycosylated hemoglobin (HbA1c) levels and type 2 diabetes mellitus (T2DM), according to a new study. http://medicalxpress.com/news/2012-05-severity-disordered-glycemic-health.html Sleep apnea Wed, 23 May 2012 09:47:52 EST news256985266 A study comparing a bariatric surgical procedure with conventional medical treatment in morbidly obese patients with type 2 diabetes mellitus suggests that surgery was associated with remission or improvement in diabetes-related outcomes, according to a report published Online First by Archives of Surgery. http://medicalxpress.com/news/2012-04-sleeve-gastrectomy-medical-treatment-obese.html Sleep apnea Mon, 16 Apr 2012 16:12:49 EST news253811475 (HealthDay) -- For patients with type 2 diabetes mellitus (T2DM) who are treated with aspirin, isoprostanes are overproduced, which is linked with enhanced platelet recruitment, according to a study published online March 16 in Diabetes. http://medicalxpress.com/news/2012-03-aspirin-platelet-isoprostanes-diabetes.html Diabetes Fri, 23 Mar 2012 14:40:39 EST news251732392 (HealthDay) -- For patients with inadequately controlled type 2 diabetes, treatment with dapagliflozin is associated with improved glycemic control, stabilized insulin dosing, and weight reductions, according to research published in the March 20 issue of the Annals of Internal Medicine. http://medicalxpress.com/news/2012-03-dapagliflozin-aids-glycemic-diabetes.html Diabetes Tue, 20 Mar 2012 13:30:01 EST news251465867