A code of silence in acute myeloid leukemia
The development of acute myeloid leukemia (AML) is associated with a variety of genetic changes. Some of these alterations are epigenetic, wherein the sequence of the genes is unchanged, but chemical modifications to the ...
Cancer
Nov 19, 2012 |
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Gene sequencing project identifies abnormal gene that launches rare childhood leukemia
Research led by the St. Jude Children's Research Hospital – Washington University Pediatric Cancer Genome Project has identified a fusion gene responsible for almost 30 percent of a rare subtype of childhood leukemia with ...
Cancer
Nov 12, 2012 |
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Biomarkers of behavior, therapeutic targets for adult B-acute lymphoblastic leukemia identified
New insight into the aggressive behavior of certain adult B-acute lymphoblastic leukemias has provided researchers with a potential new prognostic biomarker and a promising new therapeutic target.
Cancer
Oct 29, 2012 |
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Better prognosis for early blast clearance in leukemia
(HealthDay)—Patients with acute myeloid leukemia whose peripheral blood blasts clear in six days or less after chemotherapy have significantly better survival than patients whose peripheral blasts clear ...
Cancer
Oct 24, 2012 |
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Prolonged formula feeding, delay in solid foods associated with increased risk for pediatric ALL
Results of one study indicate that the risk for developing pediatric acute lymphoblastic leukemia increased the longer a baby was fed formula and the longer solid foods were delayed.
Cancer
Oct 17, 2012 |
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Targeting cancers' 'addiction' to cell-cycle proteins shuts down tumors in mice
In what they say is a promising and highly selective treatment strategy, scientists at Dana-Farber Cancer Institute have safely shut down breast cancer and a form of leukemia in mice by targeting abnormal proteins to which ...
Cancer
Oct 16, 2012 |
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Researcher pieces together AML prognosis puzzle
When patients suffering from Acute Myeloid Leukemia (AML) express high levels of the gene, MN1, an already aggressive leukemia is accelerated and shortens survival time. While that's a known fact, the mechanisms involved ...
Cancer
Oct 15, 2012 |
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New tool determines leukemia cells' 'readiness to die,' may guide clinical care
Researchers at Dana-Farber Cancer Institute have developed a novel method for determining how ready acute myeloid leukemia (AML) cells are to die, a discovery that may help cancer specialists to choose treatments option more ...
Cancer
Oct 11, 2012 |
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RNA interference for human therapy
Leading scientists in the field investigated the potential of RNA interference (RNAi) technology as a therapeutic intervention for down-regulating the expression of disease-associated genes. Project deliverables ...
Medical research
Sep 20, 2012 |
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Researchers find novel predictor for MDS progression risk
Researchers at Moffitt Cancer Center and colleagues have discovered that changes in the physical characteristics of the effector memory regulatory T cell can predict the progression risk of myelodysplastic syndromes (MDS) ...
Immunology
Sep 13, 2012 |
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Improved diagnostic test benefits children with acute myeloid leukemia
Early treatment response is a powerful predictor of long-term outcome for young patients with acute myeloid leukemia (AML). The information can help physicians decide whether a more intensive approach is needed. Research ...
Cancer
Sep 10, 2012 |
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New genetic mechanism for controlling blood cell development and blood vessel integrity found
The protein GATA2 is known as a "master regulator" of blood cell development. When a mutation occurs in the gene that makes GATA2, serious blood diseases such as acute myeloid leukemia can result.
Genetics
Sep 10, 2012 |
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Particular donor genotype lowers leukemia relapse rate
(HealthDay)—Patients with acute myeloid leukemia who receive a stem cell transplant from a donor with activating killer-cell immunoglobulin-like receptor (KIR) genotype KIR2DS1, which has ligand specif ...
Cancer
Aug 30, 2012 |
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Researchers prove that leukemias arise from changes that accumulate in blood stem cells
(Medical Xpress)—Imagine that a police bomb squad comes upon a diabolically designed bomb controlled by a tangled mass of different wires, lights and switches, some of which have a real function while others are decoys. ...
Cancer
Aug 30, 2012 |
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Gene discovery could improve treatment for acute myeloid leukemia
Scientists at Albert Einstein College of Medicine of Yeshiva University have made a discovery involving mice and humans that could mean that people with acute myeloid leukemia (AML), a rare and usually fatal cancer, are a ...
Cancer
Aug 13, 2012 |
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