Existing drugs offer new treatment options for high-risk childhood leukemia subtype
Scientists have identified new genetic alterations underlying a high-risk subtype of the most common childhood cancer that could be effectively targeted with existing leukemia therapies.
Cancer
Aug 13, 2012 |
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Marqibo approved for rare leukemia
(HealthDay) -- Marqibo (vincristine sulfate liposome injection) has been approved by the U.S. Food and Drug Administration to treat adults with a rare form of blood and bone marrow cancer, Philadelphia chromosome negative ...
Cancer
Aug 10, 2012 |
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Marqibo approved for ph- acute lymphoblastic leukemia
(HealthDay) -- Marqibo (vincristine sulfate liposome injection) has been approved by the U.S. Food and Drug Administration to treat adults with Philadelphia chromosome negative acute lymphoblastic leukemia ...
Medications
Aug 10, 2012 |
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Strategies converge on target in acute megakaryoblastic leukemia
For most cells, more than two copies of the entire genome can be a telltale sign of cancer. But for megakaryocytes – bone marrow cells that can give rise to thousands of platelets – having several ...
Cancer
Aug 07, 2012 |
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Hundreds of random mutations in leukemia linked to aging, not cancer
Hundreds of mutations exist in leukemia cells at the time of diagnosis, but nearly all occur randomly as a part of normal aging and are not related to cancer, new research shows.
Genetics
Jul 19, 2012 |
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A new target in acute myeloid leukemia
Acute myeloid leukemia, a common leukemia in adults, is characterized by aberrant proliferation of cancerous bone marrow cells. Activating mutations in a protein receptor known as FLT3 receptor are among the most prevalent ...
Cancer
Jul 16, 2012 |
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Mutation in gene IDH a possible target for AML treatment
Many patients with acute myeloid leukemia (AML) share a mutation in a gene called IDH. A University of Colorado Cancer Center study published this week in the journal Leukemia & Lymphoma shows that this IDH mutation may be ...
Cancer
Jul 13, 2012 |
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Transcription factor Lyl-1 critical in producing early T-cell progenitors
A transcription factor called Lyl-1 is necessary for production of the earliest cells that can become T-cells, critical cells born in the thymus that coordinate the immune response to cancer or infections, said a consortium ...
Immunology
Jul 08, 2012 |
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Scientists link 'oncometabolite' to onset of acute myeloid leukemia
A team of international scientists led by principal investigator Dr. Tak Mak at the Princess Margaret Cancer Centre, University Health Network, has identified a causative link between the product of a mutated metabolic enzyme ...
Cancer
Jul 04, 2012 |
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Researchers block pathway to cancer cell replication
Research suggests that patients with leukemia sometimes relapse because standard chemotherapy fails to kill the self-renewing leukemia initiating cells, often referred to as cancer stem cells. In such cancers, the cells lie ...
Cancer
Jul 02, 2012 |
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Myelodysplastic syndromes (MDS) linked to abnormal stem cells
Researchers at Albert Einstein College of Medicine of Yeshiva University have found that abnormal bone marrow stem cells drive the development of myelodysplastic syndromes (MDS), serious blood diseases that are common among ...
Medical research
Jul 02, 2012 |
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Nelarabine plus chemo viable in children with T-cell ALL
(HealthDay) -- Treatment of children with newly-diagnosed T-cell acute lymphoblastic leukemia (T-ALL) with nelarabine, in addition to an intensive Berlin-Frankfurt-Münster (BFM) 86-based chemotherapy ...
Cancer
Jun 29, 2012 |
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Myelodysplastic syndrome treated with deferasirox shows beneficial iron reduction
Researchers at Moffitt Cancer Center and colleagues at six other institutions have recently tested a treatment for patients with myelodysplastic syndrome, or MDS, a blood-related malignancy that involves the ineffective production ...
Cancer
Jun 22, 2012 |
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New breast cancer genetic alterations discovered
Breast cancer is not a single disease, but a collection of diseases with dozens of different mutations that crop up with varying frequency across different breast cancer subtypes. Deeper exploration of the genetic changes ...
Cancer
Jun 20, 2012 |
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Inhibitors of shuttle molecule show promise in acute leukemia
A novel family of experimental agents that blocks a molecule from shuttling proteins out of the cell nucleus might offer a new treatment for people with acute leukemia, according to a study by researchers at the Ohio State ...
Cancer
Jun 19, 2012 |
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