Genomics to reshape endometrial cancer treatment
The most in-depth look yet at endometrial cancer shows that adding genomics-based testing to the standard diagnostic workup could change the recommended course of treatment for some women.
Cancer
May 01, 2013 |
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Study finds mutations linked to relapse of childhood leukemia
After an intensive three-year hunt through the genome, medical researchers have pinpointed mutations that leads to drug resistance and relapse in the most common type of childhood cancer—the first time anyone has linked ...
Genetics
Feb 03, 2013 |
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Study finds new genetic defects in high-risk childhood leukemia subtypes with chromosomal loss
Research led by St. Jude Children's Research Hospital scientists has identified a possible lead in treatment of two childhood leukemia subtypes known for their dramatic loss of chromosomes and poor treatment outcomes.
Genetics
Jan 20, 2013 |
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Researchers prove that leukemias arise from changes that accumulate in blood stem cells
(Medical Xpress)—Imagine that a police bomb squad comes upon a diabolically designed bomb controlled by a tangled mass of different wires, lights and switches, some of which have a real function while others are decoys. ...
Cancer
Aug 30, 2012 |
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Scientists link 'oncometabolite' to onset of acute myeloid leukemia
A team of international scientists led by principal investigator Dr. Tak Mak at the Princess Margaret Cancer Centre, University Health Network, has identified a causative link between the product of a mutated metabolic enzyme ...
Cancer
Jul 04, 2012 |
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New breast cancer genetic alterations discovered
Breast cancer is not a single disease, but a collection of diseases with dozens of different mutations that crop up with varying frequency across different breast cancer subtypes. Deeper exploration of the genetic changes ...
Cancer
Jun 20, 2012 |
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Inherited DNA change explains overactive leukemia gene
A small inherited change in DNA is largely responsible for overactivating a gene linked to poor treatment response in people with acute leukemia.
Genetics
May 25, 2012 |
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FLT3 gene mutations play critically important role in acute myeloid leukemia
The key to treating one of the most common types of human leukemia may lie within mutations in a gene called FLT3, according to new research led by physician-scientists at the University of California, San Francisco (UCSF) ...
Cancer
Apr 15, 2012 |
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Tranylcypromine antidepressant shows promise as cancer treatment
A retinoid called all-trans retinoic acid (ATRA), which is a vitamin A-derivative, is already used successfully to treat a rare sub-type of acute myeloid leukemia (AML), however this drug has not been effective for the more ...
Cancer
Mar 11, 2012 |
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Chemotherapy may influence leukemia relapse: research
The chemotherapy drugs required to push a common form of adult leukemia into remission may contribute to DNA damage that can lead to a relapse of the disease in some patients, findings of a new study suggest.
Cancer
Jan 11, 2012 |
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Aging stem cells may explain higher prevalence of leukemia, infections among elderly
Human stem cells aren't immune to the aging process, according to scientists at the Stanford University School of Medicine. The researchers studied hematopoietic stem cells, which create the cells that comprise the blood ...
Medical research
Nov 28, 2011 |
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Researchers discover gene defect that predisposes people to leukemia
A new genetic defect that predisposes people to acute myeloid leukemia and myelodysplasia has been discovered. The mutations were found in the GATA2 gene. Among its several regulatory roles, the gene acts ...
Genetics
Sep 04, 2011 |
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Key to fighting drug-resistant leukemia found
Doctors who treat children with the most common form of childhood cancer – acute lymphoblastic leukemia – are often baffled at how sometimes the cancer cells survive their best efforts and the most powerful modern ...
Cancer
May 18, 2011 |
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Scientists assemble genetic playbook for acute leukemia
A team of researchers led by Washington University School of Medicine in St. Louis has identified virtually all of the major mutations that drive acute myeloid leukemia (AML), a fast-growing blood cancer ...
Cancer
May 01, 2013 |
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Computer algorithms help find cancer connections
Powerful data-sifting algorithms developed by computer scientists at Brown University are helping to untangle the profoundly complex genetics of cancer. In a study reported today in the New England Journal of Medicine, resear ...
Cancer
May 01, 2013 |
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