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The brain on drugs: Defining the neural anatomy and physiology of morphine on dopamine neurons

(Medical Xpress) -- Morphine's analgesic properties are as potent as its addictive potential are problematic. The neural pathway for that addiction is typically associated with dopamine (DA) neurons of the ...

Neuroscience created Oct 04, 2011 | popularity 4.8 / 5 (4) | comments 1 | with audio podcast feature

Heroin vaccine blocks relapse in preclinical study

Scientists at The Scripps Research Institute (TSRI) have reported successful preclinical tests of a new vaccine against heroin. The vaccine targets heroin and its psychoactive breakdown products in the bloodstream, preventing ...

Medical research created May 06, 2013 | popularity 5 / 5 (3) | comments 0 | with audio podcast

Resetting addicted brain: Laser light zaps away cocaine addiction

By stimulating one part of the brain with laser light, researchers at the National Institutes of Health (NIH) and the Ernest Gallo Clinic and Research Center at UC San Francisco (UCSF) have shown that they ...

Neuroscience created Apr 03, 2013 | popularity 5 / 5 (11) | comments 7 | with audio podcast

Resistance to cocaine addiction may be passed down from father to son, study shows

Research from the Perelman School of Medicine at the University of Pennsylvania and Massachusetts General Hospital (MGH) reveals that sons of male rats exposed to cocaine are resistant to the rewarding effects of the drug, ...

Neuroscience created Dec 16, 2012 | popularity 5 / 5 (1) | comments 0 | with audio podcast

Intermittent binge drinking could cause significant brain impairment within months, research shows

A study of binge-drinking rodents suggests that knocking back a few drinks every few days may swiftly reduce one's capacity to control alcohol intake. Scientists at The Scripps Research Institute (TSRI) found signs of cognitive ...

Addiction created Oct 15, 2012 | popularity 3 / 5 (2) | comments 0 | with audio podcast

Experimental drug found to reduce nicotine craving

(Medical Xpress)—Researchers at the Aptuit Centre for Drug Discovery and Development in Italy, have found that a drug called GSK598809 is able to block a type of dopamine receptor in the brain that has been ...

Neuroscience created Sep 13, 2012 | popularity 5 / 5 (1) | comments 2 | with audio podcast report

Scientists can now block heroin, morphine addiction; clinical trials possible within 18 months

In a major breakthrough, an international team of scientists has proven that addiction to morphine and heroin can be blocked, while at the same time increasing pain relief.

Neuroscience created Aug 14, 2012 | popularity 4.9 / 5 (30) | comments 8 | with audio podcast

Two-drug combination has potential to fight cocaine addiction: study

A fine-tuned combination of two existing pharmaceutical drugs has shown promise as a potential new therapy for people addicted to cocaine—a therapy that would reduce their craving for the drug and blunt their symptoms ...

Addiction created Aug 08, 2012 | popularity not rated yet | comments 1 | with audio podcast

Researchers develop novel anti-body vaccine that blocks addictive nicotine chemicals from reaching the brain

Researchers at Weill Cornell Medical College have developed and successfully tested in mice an innovative vaccine to treat nicotine addiction.

Medical research created Jun 27, 2012 | popularity 5 / 5 (7) | comments 7 | with audio podcast

Using rabies virus, researcher tracks inputs to dopamine neurons

A genetically-modified version of the rabies virus is helping scientists at Harvard to trace neural pathways in the brain, a research effort that could one day lead to treatments for Parkinson's disease and addiction.

Neuroscience created Jun 06, 2012 | popularity 5 / 5 (2) | comments 0 | with audio podcast

New kind of memory trick may help drug addicts recover

(Medical Xpress) -- Traditionally, treatment for drug addicts has centered around so-called extinction procedures designed to disassociate memories tied with taking drugs to help reduce the cravings that so often result in ...

Addiction created Apr 13, 2012 | popularity 4.7 / 5 (6) | comments 0 | with audio podcast report

Study shows how neurons interact, could lead to new treatment for addiction

Harvard scientists have developed the fullest picture yet of how neurons in the brain interact to reinforce behaviors ranging from learning to drug use, a finding that might open the door to possible breakthroughs in the ...

Neuroscience created Jan 18, 2012 | popularity 5 / 5 (4) | comments 1 | with audio podcast

A classic instinct -- salt appetite -- is linked to drug addiction

A team of Duke University Medical Center and Australian scientists has found that addictive drugs may have hijacked the same nerve cells and connections in the brain that serve a powerful, ancient instinct: ...

Medical research created Jul 11, 2011 | popularity 4.8 / 5 (11) | comments 4 | with audio podcast

'Optogenetics' used to control reward-seeking behavior

Using a combination of genetic engineering and laser technology, researchers at the University of North Carolina at Chapel Hill have manipulated brain wiring responsible for reward-seeking behaviors, such ...

Medical research created Jun 29, 2011 | popularity 4.5 / 5 (2) | comments 0 | with audio podcast

Your attention please: 'Rewarding' objects can't be ignored

The world is a dazzling array of people, objects, sounds, smells and events: far too much for us to fully experience at any moment. So our attention may automatically be snagged by something startling, such ...

Psychology & Psychiatry created Jun 07, 2011 | popularity 3.3 / 5 (3) | comments 3 | with audio podcast

Addiction

The term "addiction" is used in many contexts to describe an obsession, compulsion, or excessive psychological dependence, such as: drug addiction (e.g. alcoholism), video game addiction, crime, money, work addiction, compulsive overeating, problem gambling, computer addiction, nicotine addiction, pornography addiction, etc.

In medical terminology, an addiction is a chronic neurobiologic disorder that has genetic, psychosocial, and environmental dimensions and is characterized by one of the following: the continued use of a substance despite its detrimental effects, impaired control over the use of a drug (compulsive behavior), and preocupation with a drug's use for non-therapeutic purposes (i.e. craving the drug). Addiction is often accompanied the presence of deviant behaviors (for instance stealing money and forging prescriptions) that are used to obtain a drug.

Tolerance to a drug and physical dependence are not defining characteristics of addiction, although they typically accompany addiction to certain drugs. Tolerance is a pharmacologic phenomenon where the dose of a medication needs to be continually increase in order to maintain its desired effects. For instance, individuals with severe chronic pain taking opiate medications (like morphine) will need to continually increase the dose in order to maintain the drug's analgesic (pain-relieving) effects. Physical dependence is also a pharmacologic property and means that if a certain drug is abruptly discontinued, an individual will experience certain characteristic withdrawal signs and symptoms. Many drugs used for therapeutic purposes produce withdrawal symptoms when abruptly stopped, for instance oral steroids, certain antidepressants, benzodiazepines, and opiates.

However, common usage of the term addiction has spread to include psychological dependence. In this context, the term is used in drug addiction and substance abuse problems, but also refers to behaviors that are not generally recognized by the medical community as problems of addiction, such as compulsive overeating.

The term addiction is also sometimes applied to compulsions that are not substance-related, such as problem gambling and computer addiction. In these kinds of common usages, the term addiction is used to describe a recurring compulsion by an individual to engage in some specific activity, despite harmful consequences, as deemed by the user himself to his or her individual health, mental state or social life.

For more information about Addiction, read the full article at Wikipedia.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.

Related topics: brain , alcohol , nicotine