Pancreatic ductal adenocarcinoma (PDAC) cells maintain a high level of autophagy or degradation, allowing them to thrive in severely limiting microenvironments. However, the process via which autophagy promotes pancreatic ...
A large team of cancer researchers affiliated with multiple institutions in Germany, working with a colleague from the U.S., has discovered some of the ways gut bacteria can positively impact treatments for cancer. In their ...
Scientists at Dana-Farber Cancer Institute, the Massachusetts Institute of Technology, and other institutions have discovered a sign of the early development of pancreatic cancer – an upsurge in certain amino acids that ...
Sep 28, 2014
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Lung tumors called adenocarcinomas sometimes respond to initially effective treatments by transforming into a much more aggressive small cell lung cancer (SCLC) that spreads rapidly and has few options for treatment. Researchers ...
Feb 8, 2024
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Scar tissue that forms around a growing pancreatic tumor called a pancreatic ductal adenocarcinoma harbors valuable clues as to how long people with these cancers are likely to live, according to a new study led by researchers ...
Nov 24, 2023
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Pancreatic cancer is not just one disease, but that's the way it is currently treated. New work from Tannishtha Reya's lab could help pave the way for a change. The research is published in the journal Cancer Cell.
Nov 6, 2023
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Pancreatic cancers are among the most aggressive, deadly tumor types, and for years, researchers have struggled to develop effective drugs against the tumors. Now, Salk Institute researchers have identified a new set of molecules ...
Sep 6, 2023
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Findings from the Garvan Institute of Medical Research reveal a new Australian drug that targets scar-like 'fibrotic' tissue within tumors shows promise for treating pancreatic ductal adenocarcinoma, one of the most aggressive ...
Aug 29, 2023
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Much of the research on new cancer treatments in the last two decades has focused on genetic targets that allow cancers to grow and spread by altering cell signaling or shutting off tumor suppressors. There is a growing body ...
Apr 7, 2023
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Chemotherapy affects the ability of a patient's immune system to attack pancreatic tumors, a new study shows.
Mar 1, 2023
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Adenocarcinoma is a cancer originating in glandular tissue. This tissue is also part of a larger tissue category known as epithelial. Epithelial tissue includes skin, glands and a variety of other tissue that lines the cavities and organs of the body. Epithelium is derived embryologically from ectoderm, endoderm and mesoderm. To be classified as adenocarcinoma, the cells do not necessarily need to be part of a gland, as long as they have secretory properties. This form of carcinoma can occur in some higher mammals, including humans. Well differentiated adenocarcinomas tend to resemble the glandular tissue that they are derived from, while poorly differentiated may not. By staining the cells from a biopsy, a pathologist will determine whether the tumor is an adenocarcinoma or some other type of cancer. Adenocarcinomas can arise in many tissues of the body due to the ubiquitous nature of glands within the body. While each gland may not be secreting the same substance, as long as there is an exocrine function to the cell, it is considered glandular and its malignant form is therefore named adenocarcinoma. Endocrine gland tumors, such as a VIPoma, an insulinoma, a pheochromocytoma, etc, are typically not referred to as adenocarcinomas, but rather, are often called neuroendocrine tumors. If the glandular tissue is abnormal, but benign, it is said to be an adenoma. Benign adenomas typically do not invade other tissue and rarely metastasize. Malignant adenocarcinomas invade other tissues and often metastasize given enough time to do so.
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