A new strategy required in the search for Alzheimer's drugs?
In the search for medication against Alzheimer's disease, scientists have focused – among other factors – on drugs that can break down Amyloid beta (A-beta). After all, it is the accumulation of A-beta that causes the ...
Alzheimer's disease & dementia
May 24, 2013 |
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Carmustine decreases amyloid beta plaques
Long term treatment by carmustine, a chemical relative of mustard gas and already used to treat some types of brain cancer, can decrease the amount of amyloid β and number of amyloid plaques in a mouse model of Alzheimer's ...
Alzheimer's disease & dementia
Mar 25, 2013 |
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Zebrafish reveals central regulator for development of brain histamine system
Research has shown that mutations in the psen1 gene are common in the familial forms of Alzheimer's disease, and the Presenilin-1 protein that the gene encodes is known to be involved in the cleavage of the amyloid precursor ...
Neuroscience
Feb 05, 2013 |
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New research opens new pathway for the treatment of Alzheimer's disease
Scientists from VIB and KU Leuven have discovered a new target molecule for the development of a treatment against Alzheimer's disease. There is currently no cure for this disease. Many candidate drugs fail because they also ...
Alzheimer's disease & dementia
Dec 03, 2012 |
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Discovery sheds light on Alzheimer's mystery
(Medical Xpress)—In 1906, when Alois Alzheimer discovered the neurodegenerative disease that would later be named for him, he saw amyloid-beta plaques and neurofibrillary tangles inside the brain. Several decades later, ...
Alzheimer's disease & dementia
Oct 22, 2012 |
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'Natural' protection against Alzheimer’s disease
deCODE Genetics, together with their colleagues from the pharmaceutical company Genentech, reported today in the journal Nature the discovery of a variant of the amyloid precursor protein (APP) gene that confers protection agains ...
Alzheimer's disease & dementia
Jul 11, 2012 |
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Understanding and treating the cognitive dysfunction of Down syndrome and Alzheimer's disease
Down syndrome (DS) is the most common genetic disorder in live born children arising as a consequence of a chromosomal abnormality. It occurs as a result of having three copies of chromosome 21, instead of the usual two. ...
Psychology & Psychiatry
Mar 01, 2012 |
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Same genes linked to early- and late-onset Alzheimer's disease
The same gene mutations linked to inherited, early-onset Alzheimer's disease have been found in people with the more common late-onset form of the illness.
Alzheimer's disease & dementia
Feb 01, 2012 |
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Autism may be linked to abnormal immune system characteristics and novel protein fragment
Immune system abnormalities that mimic those seen with autism spectrum disorders have been linked to the amyloid precursor protein (APP), reports a research team from the University of South Florida's Department of Psychiatry ...
Immunology
Jan 03, 2012 |
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Characterizing a toxic offender
The brains of individuals with Alzheimer's disease contain protein aggregates called plaques and tangles, which interfere with normal communication between nerve cells and cause progressive learning and memory ...
Neuroscience
Dec 09, 2011 |
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Road block as a new strategy for the treatment of Alzheimer's
Blocking a transport pathway through the brain cells offers new prospects to prevent the development of Alzheimer's. Wim Annaert and colleagues of VIB and K.U. Leuven discovered that two main agents involved in the inception ...
Medical research
Aug 22, 2011 |
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Researchers identify how a gene linked to both Alzheimer's disease and type 2 diabetes works
Researchers at Mount Sinai School of Medicine have identified how a gene for a protein that can cause Type 2 diabetes, also possibly kills nerve cells in the brain, thereby contributing to Alzheimer's disease.
Medical research
Jul 18, 2011 |
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Case of mistaken identity: Study questions role of A-beta molecules in Alzheimer's disease pathology
Increasingly, researchers are suggesting that amyloid plaques and neurofibrillary tangles may be relatively late manifestations in the course of Alzheimer's disease (AD) pathology. Identifying earlier events ...
Neuroscience
Jun 28, 2011 |
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New biomarker may help with early diagnosis of Alzheimer's disease
A new biomarker may help identify which people with mild memory deficits will go on to develop Alzheimer's disease, according to a new study published in the June 22, 2011, online issue of Neurology, the medical journal of the ...
Neuroscience
Jun 22, 2011 |
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Weight loss after gastric bypass surgery reduces expression of Alzheimer's genes
Obesity is a risk factor for Alzheimer's disease, but weight loss due to bariatric surgery may reduce the risk of this common dementia, a new study suggests. The results will be presented Sunday at The Endocrine Society's ...
Medical research
Jun 06, 2011 |
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