(Medical Xpress) -- Morphine's analgesic properties are as potent as its addictive potential are problematic. The neural pathway for that addiction is typically associated with dopamine (DA) neurons of the ventral tegmental ...
A newly identified protein can be manipulated to make opioid painkillers effective at lower doses while also muting the reward mechanism that leads to addiction, Mount Sinai researchers have found.
Feb 12, 2018
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In the wake of an opioid-related event such as an overdose, infection, or detox admission, white patients received medication for opioid use disorder (OUD) up to 80% more frequently than Black patients and up to 25% more ...
May 10, 2023
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A new study conducted at the RI-MUHC concludes that prescribing opioid analgesics at discharge after surgery does not reduce postoperative pain and increases the risk of adverse events.
Jun 20, 2022
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An international research team has developed a new strategy that can predict the potential clinical implications of new therapeutic compounds based on simple cellular responses. This discovery was partly led by scientists ...
Sep 13, 2019
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(Medical Xpress) -- Research groups at the University of Cambridge and the Instituto de Neurociencias, in Spain, have discovered a new and unexpected mechanism by which cold sensation is regulated, and opens up the possibility ...
Jul 2, 2012
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A University of Colorado Boulder-led research team has discovered that two protein receptors in the central nervous system team up to respond to morphine and cause unwanted neuroinflammation, a finding with implications for ...
Apr 2, 2012
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Oncode Investigator Mario van der Stelt and his lab discovered a potential new drug that suppresses chemotherapy-induced neuropathic pain. The results are published in Nature Communications.
Dec 6, 2023
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The Ohio Opioid Cap Law, enacted on August 31, 2017, limited the total dose and duration of opioids that could be prescribed for minors. The anticipated benefit of cap laws in preventing opioid overdose, death and addiction ...
Nov 17, 2023
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A research team comprising members from the Department of Surgery, Department of Pharmacology and Pharmacy, Department of Anesthesiology, Department of Family Medicine and Primary Care, School of Clinical Medicine, LKS Faculty ...
Sep 19, 2023
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An analgesic (also known as a painkiller) is any member of the group of drugs used to relieve pain (achieve analgesia). The word analgesic derives from Greek an- ("without") and algos ("pain").
Analgesic drugs act in various ways on the peripheral and central nervous systems; they include paracetamol (para-acetylaminophenol, also known in the US as acetaminophen), the non-steroidal anti-inflammatory drugs (NSAIDs) such as the salicylates, and opioid drugs such as morphine and opium. They are distinct from anesthetics, which reversibly eliminate sensation.
In choosing analgesics, the severity and response to other medication determines the choice of agent; the WHO pain ladder, originally developed in cancer-related pain, is widely applied to find suitable drugs in a stepwise manner. The analgesic choice is also determined by the type of pain: for neuropathic pain, traditional analgesics are less effective, and there is often benefit from classes of drugs that are not normally considered analgesics, such as tricyclic antidepressants and anticonvulsants.
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