Neuroscience

Study reveals fentanyl's effects on the brain

Fentanyl is used to supplement sedation and to relieve severe pain during and after surgery, but it's also one of the deadliest drugs of the opioid epidemic. In research conducted by investigators at Massachusetts General ...

Medications

Ketamine's effect on depression may hinge on hope

In study after study, the psychoactive drug ketamine has given profound and fast relief to many people suffering from severe depression. But these studies have a critical shortcoming: Participants usually can tell whether ...

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Anesthesia

Anesthesia, or anaesthesia (see spelling differences; from Greek αν-, an-, "without"; and αἲσθησις, aisthēsis, "sensation"), has traditionally meant the condition of having sensation (including the feeling of pain) blocked or temporarily taken away. This allows patients to undergo surgery and other procedures without the distress and pain they would otherwise experience. The word was coined by Oliver Wendell Holmes, Sr. in 1846. Another definition is a "reversible lack of awareness", whether this is a total lack of awareness (e.g. a general anaesthetic) or a lack of awareness of a part of the body such as a spinal anaesthetic or another nerve block would cause. Anesthesia is a pharmacologically induced reversible state of amnesia, analgesia, loss of consciousness, loss of skeletal muscle reflexes and decreased stress response.

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