News tagged with animal model
Treatment with high potency statins (especially atorvastatin and simvastatin) may increase the risk of developing diabetes, suggests a paper published today in BMJ.
Diabetes May 23, 2013 | not rated yet | 0
Studying the networks of connections in the brains of people affected by schizophrenia, bipolar disease or depression has allowed Dr. Peter Williamson, from Western University, to gain a better understanding of the biological ...
Neuroscience May 23, 2013 | 4 / 5 (1) | 0
Children who have suffered maltreatment are 36% more likely to be obese in adulthood compared to non-maltreated children, according to a new study by King's College London. The authors estimate that the prevention or effective ...
Overweight and Obesity May 21, 2013 | not rated yet | 0
Infections can trigger hematopoiesis at sites outside the bone marrow – in the liver, the spleen or the skin. LMU researchers now show that a specific type of immune cell facilitates such "extra medullary" ...
Medical research May 16, 2013 | 5 / 5 (3) | 0
The Journal of the American Heart Association published the conclusive results from a study directed by Dr. Éric Thorin of the Montreal Heart Institute (MHI), which suggests for the first time that a blood protein contri ...
Cardiology May 14, 2013 | not rated yet | 0 |
(Medical Xpress)—Some parts of the body, like the liver, can regenerate themselves after damage. But others, such as our nervous system, are considered either irreparable or slow to recover, leaving thousands ...
Neuroscience May 13, 2013 | 5 / 5 (8) | 1 |
To mark the European Month of the Brain, we look at one EU-funded project that has focussed efforts on drug delivery across the so-called blood-brain barrier. The blood-brain barrier (BBB), while preforming ...
Medical research May 13, 2013 | not rated yet | 0
How do organisms evolve into individuals that are distinguished from others by their own personal brain structure and behavior? Scientists in Dresden, Berlin, Münster, and Saarbrücken have now taken a decisive step towards ...
Neuroscience May 09, 2013 | 5 / 5 (9) | 0 |
New engineered spider protein could be the start of a new generation of anti-venom vaccines, potentially saving thousands of lives worldwide. The new protein, created from parts of a toxin from the reaper ...
Medications May 09, 2013 | 5 / 5 (3) | 0 |
Researchers at Lund University in Sweden have developed a new mouse model that answers the question of what actually happens in the body when type 2 diabetes develops and how the body responds to drug treatment. Long-term ...
Diabetes May 03, 2013 | 3.3 / 5 (3) | 1
A study appearing in the Journal of Nutritional Biochemistry demonstrates that grapes are able to reduce heart failure associated with chronic high blood pressure (hypertension) by increasing the activity of several genes ...
Cardiology May 02, 2013 | 4.8 / 5 (4) | 0 |
Scientists have identified an influential link in a chain of events that leads to autoimmune inflammation of the central nervous system in a mouse model of multiple sclerosis (MS).
Medical research May 02, 2013 | 5 / 5 (4) | 0 |
Inflammatory bowel diseases (IBD), such as Crohn's disease and ulcerative colitis, may be detected and monitored more effectively in the future with positron emission tomography/computed tomography (PET/CT), according to ...
Diseases, Conditions, Syndromes May 01, 2013 | not rated yet | 0
Many diseases – obesity, Type 2 diabetes, muscular dystrophy – are associated with fat accumulation in muscle. In essence, fat replacement causes the muscles to weaken and degenerate.
Medical research Apr 30, 2013 | 4.5 / 5 (2) | 0 |
With the remains of a recent lottery winner having been exhumed for foul play related to cyanide poisoning, future winners might wonder what they can do to avoid the same fate. A new report in The FASEB Journal involving zebrafish ...
Medical research Apr 30, 2013 | 5 / 5 (1) | 0
An animal model is a non-human animal that has a disease or injury that is similar to a human condition. These test conditions are often termed as animal models of disease. The use of animal models allows researchers to investigate disease states in ways which would be inaccessible in a human patient, performing procedures on the non-human animal that imply a level of harm that would not be considered ethical to inflict on a human.
In order to serve as a useful model, a modeled disease must be similar in etiology (mechanism of cause) and function to the human equivalent. Animal models are used to learn more about a disease, its diagnosis and its treatment. For instance, behavioral analogues of anxiety or pain in laboratory animals can be used to screen and test new drugs for the treatment of these conditions in humans. A 2000 study found that animal models predicted human toxicity in 71% of cases, with 63% for nonrodents alone and 43% for rodents alone.
Animal models of disease can be spontaneous (naturally occurring in animals), or be induced by physical, chemical or biological means. For example,
The increase in knowledge of the genomes of non-human primates and other mammals that are genetically close to humans is allowing the production of genetically engineered animal tissues, organs and even animal species which express human diseases, providing a more robust model of human diseases in an animal model.
Animal models observed in the sciences of psychology and sociology are often termed animal models of behavior.
In quantitative genetics, the term animal model is used to refer to statistical models in which phenotypic variance is compartmentalised into environmental, genetic and sometimes maternal effects. Such animal models are also known as "mixed models".
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