News tagged with animal model
New study validates longevity pathway: Findings identify universal mechanism for activating anti-aging pathway
A new study demonstrates what researchers consider conclusive evidence that the red wine compound resveratrol directly activates a protein that promotes health and longevity in animal models. What's more, the researchers ...
Medical research Mar 07, 2013 | 4.8 / 5 (20) | 6 |
People with autism suffer from a pervasive developmental disorder of the brain that becomes evident in early childhood. Peter Scheiffele and Kaspar Vogt, Professors at the Biozentrum of the University of ...
Autism spectrum disorders Sep 14, 2012 | 4.9 / 5 (11) | 1 |
How do organisms evolve into individuals that are distinguished from others by their own personal brain structure and behavior? Scientists in Dresden, Berlin, Münster, and Saarbrücken have now taken a decisive step towards ...
Neuroscience May 09, 2013 | 5 / 5 (9) | 0 |
(Medical Xpress)—Some parts of the body, like the liver, can regenerate themselves after damage. But others, such as our nervous system, are considered either irreparable or slow to recover, leaving thousands ...
Neuroscience May 13, 2013 | 5 / 5 (8) | 1 |
Scientists at The Scripps Research Institute (TSRI) have shed light on one of the major toxic mechanisms of Alzheimer's disease. The discoveries could lead to a much better understanding of the Alzheimer's process and how ...
Neuroscience Apr 10, 2013 | 5 / 5 (6) | 0 |
It is not unusual for babies to be born with congenital heart defects. This is because the development of the heart in the embryo is a process which is not only extremely complex, but also error-prone. Scientists ...
Medical research Jul 12, 2012 | 4.7 / 5 (6) | 0 |
Last March, researchers at UCLA reported the development of a molecular compound called CLR01 that prevented toxic proteins associated with Parkinson's disease from binding together and killing the brain's neurons.
Alzheimer's disease & dementia Nov 15, 2012 | 4.5 / 5 (6) | 3 |
Chronic exposure to dim light at night can lead to depressive symptoms in rodents -- but these negative effects can be reversed simply by returning to a standard light-dark cycle, a new study suggests.
Psychology & Psychiatry Jul 24, 2012 | 5 / 5 (5) | 0 |
Scientists have found that eliminating an enzyme from mice with symptoms of Alzheimer's disease leads to a 90 percent reduction in the compounds responsible for formation of the plaques linked to Alzheimer's disease.
Alzheimer's disease & dementia Sep 05, 2012 | 5 / 5 (5) | 0 |
Caenorhabditis elegans, with just 302 neurons, has long been considered an ideal model system for the study of the nervous system. New research, however, is suggesting that the worms' "simple" nervous system may be much m ...
Neuroscience Nov 21, 2012 | 5 / 5 (5) | 0 |
(HealthDay)—A new, lab-created antibody that mimics the action of a naturally occurring molecule causes weight loss in monkeys, researchers report.
Medical research Nov 28, 2012 | 5 / 5 (5) | 0 |
Researchers from the Universitat Autònoma de Barcelona (UAB), led by Fàtima Bosch, have shown for the first time that it is possible to cure diabetes in large animals with a single session of gene therapy. ...
Diabetes Feb 07, 2013 | 5 / 5 (5) | 0
(Medical Xpress)—Researchers from Australia and the USA have made a unique discovery about how the brain computes sensory information.
Neuroscience Nov 15, 2012 | 4.4 / 5 (5) | 1 |
Scientists at the Gladstone Institutes have discovered that an FDA-approved anti-epileptic drug reverses memory loss and alleviates other Alzheimer's-related impairments in an animal model of the disease.
Alzheimer's disease & dementia Aug 06, 2012 | 5 / 5 (4) | 1 |
We should reconsider how we use antidepressants more effectively. The latest studies have shown that antidepressants restore the capacity of certain areas of the brain to repair abnormal neural pathways. According to neuroscientist ...
Psychology & Psychiatry Feb 22, 2013 | 5 / 5 (4) | 2
An animal model is a non-human animal that has a disease or injury that is similar to a human condition. These test conditions are often termed as animal models of disease. The use of animal models allows researchers to investigate disease states in ways which would be inaccessible in a human patient, performing procedures on the non-human animal that imply a level of harm that would not be considered ethical to inflict on a human.
In order to serve as a useful model, a modeled disease must be similar in etiology (mechanism of cause) and function to the human equivalent. Animal models are used to learn more about a disease, its diagnosis and its treatment. For instance, behavioral analogues of anxiety or pain in laboratory animals can be used to screen and test new drugs for the treatment of these conditions in humans. A 2000 study found that animal models predicted human toxicity in 71% of cases, with 63% for nonrodents alone and 43% for rodents alone.
Animal models of disease can be spontaneous (naturally occurring in animals), or be induced by physical, chemical or biological means. For example,
The increase in knowledge of the genomes of non-human primates and other mammals that are genetically close to humans is allowing the production of genetically engineered animal tissues, organs and even animal species which express human diseases, providing a more robust model of human diseases in an animal model.
Animal models observed in the sciences of psychology and sociology are often termed animal models of behavior.
In quantitative genetics, the term animal model is used to refer to statistical models in which phenotypic variance is compartmentalised into environmental, genetic and sometimes maternal effects. Such animal models are also known as "mixed models".
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