News tagged with animal model
Related topics: mouse model , cancer cells , nerve cells , proceedings of the national academy of sciences , cells
An animal model is a non-human animal that has a disease or injury that is similar to a human condition. These test conditions are often termed as animal models of disease. The use of animal models allows researchers to investigate disease states in ways which would be inaccessible in a human patient, performing procedures on the non-human animal that imply a level of harm that would not be considered ethical to inflict on a human.
In order to serve as a useful model, a modeled disease must be similar in etiology (mechanism of cause) and function to the human equivalent. Animal models are used to learn more about a disease, its diagnosis and its treatment. For instance, behavioral analogues of anxiety or pain in laboratory animals can be used to screen and test new drugs for the treatment of these conditions in humans. A 2000 study found that animal models predicted human toxicity in 71% of cases, with 63% for nonrodents alone and 43% for rodents alone.
Animal models of disease can be spontaneous (naturally occurring in animals), or be induced by physical, chemical or biological means. For example,
The increase in knowledge of the genomes of non-human primates and other mammals that are genetically close to humans is allowing the production of genetically engineered animal tissues, organs and even animal species which express human diseases, providing a more robust model of human diseases in an animal model.
Animal models observed in the sciences of psychology and sociology are often termed animal models of behavior.
In quantitative genetics, the term animal model is used to refer to statistical models in which phenotypic variance is compartmentalised into environmental, genetic and sometimes maternal effects. Such animal models are also known as "mixed models".
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
The Journal of the American Heart Association published the conclusive results from a study directed by Dr. Éric Thorin of the Montreal Heart Institute (MHI), which suggests for the first time that a blood protein contri ...
Cardiology May 14, 2013 | not rated yet | 0 |
(Medical Xpress)—Some parts of the body, like the liver, can regenerate themselves after damage. But others, such as our nervous system, are considered either irreparable or slow to recover, leaving thousands ...
Neuroscience May 13, 2013 | 5 / 5 (8) | 1 |
Infections can trigger hematopoiesis at sites outside the bone marrow – in the liver, the spleen or the skin. LMU researchers now show that a specific type of immune cell facilitates such "extra medullary" ...
Medical research May 16, 2013 | 5 / 5 (3) | 0
To mark the European Month of the Brain, we look at one EU-funded project that has focussed efforts on drug delivery across the so-called blood-brain barrier. The blood-brain barrier (BBB), while preforming ...
Medical research May 13, 2013 | not rated yet | 0