Immunology

Gut throws cells overboard when chemical insults build up

A team of Duke researchers has discovered that cells lining the gut of zebrafish—and probably humans too—have a remarkable defense mechanism when faced with certain kinds of toxins: they hit the eject button.

Medical research

Study puts a new spin on ibuprofen's actions

Ibuprofen, naproxen, and related non-steroidal anti-inflammatory drugs (NSAIDs) – the subjects of years of study – still have some secrets to reveal about how they work.

Endocrinology & Metabolism

Acetylation: A timekeeper of glucocorticoid sensitivity

Cortisol, also commonly known as the stress hormone, belongs to the family of glucocorticoids. In addition to its physiological function, synthetic derivatives of cortisol are also used as anti-inflammatory drugs. In the ...

Diseases, Conditions, Syndromes

Tobacco smoke exposure linked to increased risk of tuberculosis

Researchers at Massachusetts General Hospital (MGH) have identified a potential mechanism by which tobacco smoking drives a type of white blood cell known as monocytes to the lung where they can increase the risk of active ...

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Non-steroidal anti-inflammatory drug

Non-steroidal anti-inflammatory drugs, usually abbreviated to NSAIDs or NAIDs, are drugs with analgesic, antipyretic (lowering an elevated body temperature and relieving pain without impairing consciousness) and, in higher doses, with anti-inflammatory effects (reducing inflammation). The term "non-steroidal" is used to distinguish these drugs from steroids, which (among a broad range of other effects) have a similar eicosanoid-depressing, anti-inflammatory action. As analgesics, NSAIDs are unusual in that they are non-narcotic.

NSAIDs are sometimes also referred to as non-steroidal anti-inflammatory agents/analgesics (NSAIAs) or non-steroidal anti-inflammatory medicines (NSAIMs). The most prominent members of this group of drugs are aspirin, ibuprofen, and naproxen partly because they are available over-the-counter in many areas.

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