Genetics

Gene therapy beneficial for patients with hemophilia B

For patients with hemophilia B, one infusion of adeno-associated virus 5 (AAV5) vector expressing the Padua factor IX variant (etranacogene dezaparvovec) is noninferior and superior to prophylaxis with factor IX, according ...

Genetics

How genes can affect antibodies against SARS-CoV-2

Ph.D. student Pradeepa Pushparaj, in Gunilla Karlsson Hedestams group at the Department of Microbiology, Tumor and Cell Biology, is the first author of a study recently published in Immunity.

Diseases, Conditions, Syndromes

Powerful new antibody neutralizes all known SARS-CoV-2 variants

As SARS-CoV-2 has evolved and mutated, therapeutic antibodies that worked early in the pandemic have become less effective, and newer variants, especially omicron, have developed ways to evade the antibodies we make in response ...

Medical research

Unsung gene is key to how antibodies develop: study

Researchers at the University of Toronto have discovered that an overlooked gene plays a major role in the development of antibodies, which help the immune system recognize and fight viruses including SARS-CoV-2, bacteria ...

Diseases, Conditions, Syndromes

How 'Long COVID' affects our immune systems

A world-leading research collaboration in South Australia has delivered crucial insight into the lasting immune system dysregulation caused by COVID-19.

Medical research

How the production of antibodies is regulated, one cell at a time

A study coordinated by Luís Graça, principal investigator at the Instituto de Medicina Molecular João Lobo Antunes (iMM; Portugal) and Professor at the Faculty of Medicine of the University of Lisbon (FMUL) used lymph ...

Diseases, Conditions, Syndromes

US scientists developing nasal spray to prevent COVID-19

Scientists at the University of Pennsylvania and the biotech firm Regeneron are investigating whether technology developed for gene therapy can be used to make a nasal spray that will prevent infection with the new coronavirus.

Genetics

Team succeeds in inhibiting the immune response linked to AAV

A research team from Genethon, in collaboration with teams from CNRS/Inserm and from the biotechnology company Spark Therapeutics, announced today in Nature Medicine that it has succeeded in inhibiting the immune response ...

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