Researchers at Gladstone Institutes have discovered that a rare genetic variant known as the "Christchurch mutation" can block detrimental effects of apolipoprotein E4, the best-established risk factor for the most common ...
Nov 13, 2023
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If you're one of the nearly 25 percent of people with the gene variant known as APOE4, you have a higher-than-average chance of developing Alzheimer's disease. But while scientists have long known that APOE4 leads to changes ...
Oct 20, 2023
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Researchers at the University of Pittsburgh analyzed thousands of human genomes to find new gene variations responsible for controlling the levels of blood plasma molecules linked to Alzheimer's disease risk. The findings, ...
Sep 6, 2023
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A new dementia risk score, which draws on 11 mostly modifiable risk factors, identifies people at risk—from midlife onward—of developing the disease within the next 14 years, suggests a large long term study published ...
Aug 25, 2023
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Of all the known genetic risk factors for late-onset Alzheimer's disease, the strongest is a gene for the protein called ApoE4. People with one copy of this gene are 3.5 times more likely, on average, to develop Alzheimer's ...
Feb 21, 2023
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It's well known that carrying one copy of the APOE4 gene variant increases one's risk for Alzheimer's disease threefold and two copies about tenfold, but the fundamental reasons why and what can be done to help patients remain ...
Nov 16, 2022
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Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia, affecting more than 5.8 million individuals in the U.S. Scientists have discovered some genetic variants that increase ...
Jun 23, 2022
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The APOE4 gene is the most powerful genetic factor driving a person's risk for developing late-onset Alzheimer's disease.
Jun 1, 2022
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The brain has a natural protective mechanism against Alzheimer's disease, and researchers at Baylor College of Medicine, Texas Children's Hospital and collaborating institutions have discovered that gene variants associated ...
Dec 28, 2021
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New research published in Stem Cell Reports has found elevated cholesterol supply from astrocytes to neurons in the model of Alzheimer's disease (AD) brains, suggesting that modulating brain cholesterol could be explored ...
Aug 26, 2021
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