News tagged with binding protein

Related topics: protein

A noncoding RNA promotes pediatric bone cancer

Ewing sarcoma is a cancer of bone or its surrounding soft tissue that primarily affects children and young adults. A hallmark of Ewing sarcoma is a translocation event that results in the fusion of an RNA binding protein, ...

Nov 17, 2014
popularity 5 / 5 (1) | comments 0

30-year puzzle in breast cancer solved

In a new study published today in Cell Reports, scientists at the Fred Hutchinson Cancer Research Center demonstrate that mice lacking one copy of a gene called CTCF have abnormal DNA methylation and are ma ...

May 02, 2014
popularity 4.5 / 5 (6) | comments 0

New molecules doom proteins with kiss of death

Like mobsters following strict orders, newly engineered molecules called "ubiquibodies" can mark specific proteins inside a cell for destruction – a molecular kiss of death that is paving the way for new drug therapies ...

Mar 05, 2014
popularity 5 / 5 (1) | comments 0

Breast cancer drug fights fungal disease

Tamoxifen, a drug currently used to treat breast cancer, also kills a fungus that causes a deadly brain infection in immunocompromised patients. The findings, which could lead to new treatments for a disease that kills more ...

Feb 11, 2014
popularity 5 / 5 (1) | comments 0

The logistics of learning

Learning requires constant reconfiguration of the connections between nerve cells. Two new studies now yield new insights into the molecular mechanisms that underlie the learning process.

Dec 20, 2013
popularity 5 / 5 (1) | comments 0

New knowledge on molecular mechanisms behind breast cancer

Researchers at University of Copenhagen have gained more insight into the molecular mechanisms of importance for, for example, cancer cell growth and metastasis. The research objective is improved and more targeted drugs. ...

Sep 25, 2013
popularity 5 / 5 (1) | comments 0

Study explores barriers to HIV vaccine response

Researchers at The Scripps Research Institute (TSRI) discovered that an antibody that binds and neutralizes HIV likely also targets the body's own "self" proteins. This finding could complicate the development of HIV vaccines ...

Sep 20, 2013
popularity 5 / 5 (1) | comments 0 | with audio podcast

When cells are consumed by wanderlust

(Medical Xpress)—In experiments on zebrafish, Freiburg researchers have demonstrated that the same proteins that lead to the formation of metastases in humans also cause the cells to migrate during embryonic ...

Jul 22, 2013
popularity 5 / 5 (2) | comments 0 | with audio podcast

Decoding Rett syndrome: New pieces to the puzzle

(Medical Xpress)—Rett Syndrome is a neurological disorder that affects about 1 in 10,000 girls. Back in 1992, University of Edinburgh researcher Adrian Bird discovered that the protein, MeCP2, plays a major ...

Jun 17, 2013
popularity 4.3 / 5 (4) | comments 0 | with audio podcast report

Carrier protein

Carrier proteins are proteins that transport a specific substance or group of substances through intracellular compartments or in extracellular fluids (e.g. in the blood) or else across the cell membrane. Some of the carriers are water-soluble proteins that may or may not interact with biological membranes, such as some transporters of small hydrophobic molecules, whereas others are integral transmembrane proteins.

Carrier proteins transport substances out of or into the cell by facilitated diffusion and active transport. Each carrier protein is designed to recognize only one substance or one group of very similar substances. The molecule or ion to be transported (the substrate) must first bind at a binding site at the carrier molecule, with a certain binding affinity. Following binding, and while the binding site is facing, say, outwards, the carrier will capture or occlude (take in and retain) the substrate within its molecular structure and cause an internal translocation, so that it now faces the other side of the membrane. The substrate is finally released at that site, according to its binding affinity there. All steps are reversible.

For example:

This text uses material from Wikipedia licensed under CC BY-SA