'Traffic' in our cells works both for and against us
A mechanism that permits essential substances to enter our cells while at the same time removing from them harmful components also has a "down side." This negative aspect prevents vital drugs, such as anti-cancer drugs, from ...
Medical research
May 01, 2013 |
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Better 'mousetrap' discovered in fruit flies might stop human cancer-driving kinase in its tracks
A seemingly obscure gene in the female fruit fly that is only active in cells that will become eggs has led researchers at the Stowers Institute for Medical Research to the discovery of a atypical protein ...
Cancer
Mar 13, 2013 |
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From protein signaling to cancer drug development
(Medical Xpress)—Living organisms depend on proteins for their survival. These large, complex molecules mediate nearly every life function, but when the genes that code for them start to mutate, ...
Cancer
Jan 08, 2013 |
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Serendipity points to new potential target and therapy for melanoma
(Medical Xpress)—A University of Colorado Cancer Center study in this month's edition of the Journal of Investigative Dermatology describes a new target and potential treatment for melanoma, the most d ...
Cancer
Dec 20, 2012 |
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New findings on glucagon synthesis
Researchers at Karolinska Institutet in Sweden have shown that the cells that produce glucagon are stimulated by the hormone itself. A previous study by the same group demonstrated that this principle also applies to insulin. ...
Medical research
Dec 03, 2012 |
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Team pinpoints amino acid variation in immune response gene linked with ulcerative colitis
The association between the inflammatory bowel disease ulcerative colitis and a gene that makes certain cell surface proteins has been pinpointed to a variant amino acid in a crucial binding site that profoundly influences ...
Immunology
Dec 15, 2011 |
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Researchers determine how antibody recognizes key sugars on HIV surface
HIV is coated in sugars that usually hide the virus from the immune system. Newly published research reveals how one broadly neutralizing HIV antibody actually uses part of the sugary cloak to help bind to the virus. The ...
HIV & AIDS
Nov 23, 2011 |
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Biologists create anti-HIV antibody that shows increased potency
Using highly potent antibodies isolated from HIV-positive people, researchers have recently begun to identify ways to broadly neutralize the many possible subtypes of HIV. Now, a team led by biologists at ...
HIV & AIDS
Oct 27, 2011 |
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Key function of mutation in hereditary breast and ovarian cancer gene discovered
It is widely known that mutations in the breast cancer susceptibility 1 (BRCA1) gene significantly increase the chance of developing breast and ovarian cancers, but the mechanisms at play are not fully understood. Now, researchers ...
Genetics
Sep 01, 2011 |
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Scientists map route for eliciting HIV-neutralizing antibodies
Researchers have traced in detail how certain powerful HIV neutralizing antibodies evolve, a finding that generates vital clues to guide the design of a preventive HIV vaccine, according to a study appearing in Science Ex ...
HIV & AIDS
Aug 11, 2011 |
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Scientists identify broad and potent HIV antibodies that mimic CD4 binding
In a finding that may be good news for scientists developing HIV vaccines and therapies, a team of researchers at The Rockefeller University and the Howard Hughes Medical Institute have found a way to investigate ...
HIV & AIDS
Jul 20, 2011 |
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One drug, many targets: Finding molecular targets of an HIV drug used in cancer therapy
Researchers at the University of California, San Diego and Hunter College of the City University of New York (CUNY) have identified potential human molecular targets of the anti-HIV drug Nelfinavir, which may explain why ...
Medications
Apr 28, 2011 |
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