News tagged with biocompatibility
Biocompatibility is related to the behavior of biomaterials in various contexts. The term may refer to specific properties of a material without specifying where or how the material is used (for example, that it elicits little or no immune response in a given organism, or is able to integrate with a particular cell type or tissue), or to more empirical clinical success of a whole device in which the material or materials feature. The ambiguity of the term reflects the ongoing development of insights into how biomaterials interact with the human body and eventually how those interactions determine the clinical success of a medical device (such as pacemaker, hip replacement or stent). Modern medical devices and prostheses are often made of more than one material so it might not always be sufficient to talk about the biocompatibility of a specific material.
Indeed, since the immune response and repair functions in the body are so complicated it is not adequate to describe the biocompatibility of a single material in relation to a single cell type or tissue. Sometimes one hears of biocompatibility testing that is a large battery of in vitro test that is used in accordance with ISO 10993 (or other similar standards) to determine if a certain material (or rather biomedical product) is biocompatible. These tests do not determine the biocompatibility of a material, but they constitute an important step towards the animal testing and finally clinical trials that will determine the biocompatibility of the material in a given application, and thus medical devices such as implants or drug delivery devices.
The word biocompatibility seems have been mentioned for the first time in peer-review journals and meetings in 1970 by RJ Hegyeli (Amer Chem Soc Annual Meeting abstract) and CA Homsy et al. ( J Macromol Sci Chem A4:3,615, 1970). It took almost two decades before it began to be commonly used in scientific literature (see the graph below).
Recently Williams (again) has been trying to re-evaluate the current knowledge status regarding what factors determine clinical success. Doing so notes that an implant may not always have to be positively bioactive but it must not do any harm (either locally or systematically) (Williams, 2008).
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
Elderly or people with osteoporosis, smokers, diabetics or people who have had cancer are sometimes not eligible to receive dental implants as their bones are unable to correctly integrate the new prostheses which replace ...
Dentistry Apr 29, 2013 | not rated yet | 0
Replacement of prostheses is unpleasant to the patient and expensive to society. Replacement of failed hip prostheses gives rise to an expenditure of about 10 million euros yearly in Finland. A usual reason ...
Medical research Mar 13, 2013 | not rated yet | 0
Elderly or people with osteoporosis, smokers, diabetics or people who have had cancer are sometimes not eligible to receive dental implants as their bones are unable to correctly integrate the new prostheses ...
Medical research Jan 21, 2013 | 3 / 5 (1) | 0
Professor Jose Miguel Soria, a member of the Institute of Biomedical Sciences, Universidad CEU Cardenal Herrera, has co-directed with Professor Manuel Monleón of the Universitat Politecnica de Valencia a study on the compatibility ...
Neuroscience Nov 29, 2012 | not rated yet | 0
(HealthDay)—Compared with high-density porous polyethylene (HDPPE) implant materials, sphere-templated poly (2-hydroxyethyl methacrylate) (poly[HEMA]) tissue scaffold stimulates a minimal inflammatory response; ...
Surgery Oct 14, 2012 | not rated yet | 0
(Medical Xpress) -- A new study from the University of Reading has established that a prosthetic cornea made from human cells is the best model for testing how irritants and toxins cause eye injuries.
Ophthalmology May 28, 2012 | not rated yet | 0 |