News tagged with bisphosphonates
Treatment with bisphosphonates associated with increased risk of atypical femoral fractures
Treatment with bisphosphonate therapy appears to be associated with an increased risk of atypical fractures of the femur, according to a report published Online First by Archives of Internal Medicine.
Diseases, Conditions, Syndromes
May 21, 2012 |
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Drugs reduce bone cancer damage but clinical guidance remains non-specific
Bone cancer-related fractures and pain can be reduced by drug treatment, but no one drug is superior, according to a review published in The Cochrane Library. Researchers undertook a systematic review of the current eviden ...
Cancer
May 15, 2012 |
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Osteoporosis drugs may increase risk of serious eye disease
Drugs that are commonly used to prevent osteoporosis may increase the risk of serious inflammatory eye disease in first-time users, found an article in CMAJ (Canadian Medical Association Journal).
Ophthalmology
Apr 02, 2012 |
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Low bone density medications may have protective effect on endometrial cancer
Low bone density medications, such as Fosamax, Boniva and Actonel, may have a protective effect for endometrial cancer, according to a study at Henry Ford Hospital.
Cancer
Mar 21, 2012 |
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Study pinpoints genetic variation that raises a risk linked to bisphosphonates
Researchers at the Columbia University College of Dental Medicine have identified a genetic variation that raises the risk of developing serious necrotic jaw bone lesions in patients who take bisphosphonates, a common class ...
Cancer
Jan 27, 2012 |
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Study: Bone drug boosts breast cancer survival
(AP) -- Doctors were mostly hoping to prevent complications and relapses when they gave young women a medicine to keep their bones strong during breast cancer treatment. Seven years later, they found it did more than that: ...
Cancer
Dec 09, 2011 |
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Oral bisphosphonate did not improve prognosis for patients with breast cancer
Results from a German study demonstrated no improvement in disease-free survival among patients with breast cancer who were treated with dose-dense chemotherapy and the bisphosphonate ibandronate.
Cancer
Dec 07, 2011 |
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Clodronate appeared safe, modestly affected breast cancer disease events
A recently presented study revealed that the bisphosphonate clodronate had a low incidence of adverse events and toxicity among patients with breast cancer and may modestly reduce the incidence of distant metastases in postmenopausal ...
Cancer
Dec 07, 2011 |
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Immediate bisphosphonate use with endocrine therapy increased survival in postmenopausal early breast cancer
The addition of zoledronic acid to adjuvant endocrine therapy increased bone mineral density and reduced the risk for disease recurrence among postmenopausal women with early hormone receptor-positive breast cancer, according ...
Cancer
Dec 07, 2011 |
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Common bone drug may extend life of replacement joints
People who take bisphosphonates after joint replacement surgery are less likely to need a repeat operation, finds a new study published in the British Medical Journal today.
Medications
Dec 07, 2011 |
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Zoledronic acid reduces the recurrence of breast cancer in post-menopausal women
A trial investigating the use of zoledronic acid to aid chemotherapy for breast cancer has found a significant benefit for post-menopausal women, according to results presented at the 2011 European Multidisciplinary Cancer ...
Cancer
Sep 25, 2011 |
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Low vitamin D levels are related to decreased response to osteoporosis medicine
Women with low bone density are seven times more likely to benefit from a bisphosphonate drug when their vitamin D blood levels are above recent recommendations from the Institute of Medicine (IOM) as adequate for bone health. ...
Health
Jun 06, 2011 |
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Experts question whether preventive drugs are value for money
Experts today challenge the view that popular drugs to prevent disease - like statins and antihypertensives to prevent heart disease and stroke, or bisphosphonates to prevent fractures – represent value for money.
Medications
Apr 20, 2011 |
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Bisphosphonate
In pharmacology, bisphosphonates (also called diphosphonates) are a class of drugs that prevent the loss of bone mass, used to treat osteoporosis and similar diseases.
Bone has constant turnover, and is kept in balance (homeostasis) by osteoblasts creating bone and osteoclasts digesting bone. Bisphosphonates inhibit the digestion of bone by osteoclasts.
Osteoclasts also have constant turnover and normally destroy themselves by a process called cell suicide (apoptosis). Bisphosphonates encourage osteoclasts to undergo apoptosis.
The uses of bisphosphonates include the prevention and treatment of osteoporosis, osteitis deformans ("Paget's disease of bone"), bone metastasis (with or without hypercalcaemia), multiple myeloma, primary hyperparathyroidism, osteogenesis imperfecta and other conditions that feature bone fragility.
For more information about Bisphosphonate, read the full article at
Wikipedia.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
