PARP inhibitor shows activity in pancreatic, prostate cancers among patients carrying BRCA mutations
In the largest clinical trial to date to examine the efficacy of PARP inhibitor therapy in BRCA 1/2 carriers with diseases other than breast and ovarian cancer, the oral drug olaparib was found to be effective against advanced ...
Cancer
May 15, 2013 |
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What is BRCA1?
Actress Angelina Jolie has today written an op-ed in the New York Times explaining that she has opted to have a double mastectomy because she carries the hereditary BRCA1 gene, which she says increases her risk o ...
Cancer
May 15, 2013 |
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Three mutations at BRCA1 gene responsible for breast and ovarian hereditary cancer
Researchers of the hereditary cancer research group at the Bellvitge Biomedical Research Institute (IDIBELL) and the Catalan Institute of Oncology (ICO) conducted a functional and structural study of seven missense variants ...
Cancer
Apr 18, 2013 |
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New DNA sequences hone in on breast, ovarian cancer risk
Researchers at Mayo Clinic Cancer Center have identified new DNA sequences associated with breast cancer—the most common cancer among women, with an average risk of developing the disease of 10 percent—and ovarian cancer, ...
Cancer
Mar 27, 2013 |
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Chemo given into the abdomen could boost ovarian cancer survival
Chemotherapy given straight into the abdomen of certain ovarian cancer patients could allow them to live an extra three years on average, according to new research published in the British Journal of Cancer.
Cancer
Mar 06, 2013 |
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Gene mutation's benefit for ovarian cancer patients may not last: study
(HealthDay)—Although women diagnosed with ovarian cancer who carry a BRCA gene mutation have a short-term survival advantage, this benefit is not reflected in the long-term, according to a new study.
Cancer
Feb 20, 2013 |
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Consumers have few negative reactions to the results of genetic testing for cancer mutations
A 23andMe study of consumers' reactions to genetic testing found that even when the tests revealed high-risk mutations in individuals, those individuals had few negative reactions to the news. Instead of inducing serious ...
Cancer
Feb 12, 2013 |
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Scientists identify molecular link between metabolism and breast cancer
(Medical Xpress)—A protein associated with conditions of metabolic imbalance, such as diabetes and obesity, may play a role in the development of aggressive forms of breast cancer, according to new findings by researchers ...
Cancer
Feb 06, 2013 |
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Early menopause may occur in women with BRCA gene, study finds
Women with harmful mutations in the BRCA gene, which put them at higher risk of developing breast and ovarian cancer, tend to undergo menopause significantly sooner than other women, allowing them an even ...
Cancer
Jan 29, 2013 |
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New test predicted presence of harmful BRCA mutations
A new multiple gene expression profile test was able to predict the presence of harmful BRCA1 or BRCA2 mutations in otherwise healthy women carrying the mutations, according to data published in Cancer Prevention Research, a jour ...
Cancer
Jan 22, 2013 |
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Researchers uncover novel role of BRCA1 in regulating the survival of skin stem cells
Our DNA, which stores our genetic information, is constantly exposed to damage. If not properly repaired, DNA damage can lead to cell death. This, in turn, can lead to tissue exhaustion and ageing, or induce mutations resulting ...
Cancer
Jan 03, 2013 |
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Scientists discover gene linked to breast and ovarian cancer
(Medical Xpress)—A team of researchers led by the Institute of Cancer Research, London, have found that rare mutations in a gene called PPM1D are linked to an increased risk of breast and ovarian cancer. The mutations are ...
Cancer
Dec 17, 2012 |
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Study uncovers mechanism used by BRCA1 to suppress tumors
A new study by Georgetown University Medical Center researchers reveals how a well-known tumor suppressor gene may be functioning to stop cancer cell growth.
Cancer
Dec 17, 2012 |
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Most women who have double mastectomy don't need it, study finds
About 70 percent of women who have both breasts removed following a breast cancer diagnosis do so despite a very low risk of facing cancer in the healthy breast, new research from the University of Michigan Comprehensive ...
Cancer
Nov 27, 2012 |
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Study reveals young women with the BRCA mutation feel different and misunderstood
(Medical Xpress)—A study authored by Rebekah Hamilton, RN, PhD, associate dean of the Rush University College of Nursing, found that young women with a BRCA1 and BRCA2 gene mutation felt different and misunderstood.
Cancer
Sep 26, 2012 |
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