News tagged with cancer drug development
Study IDs key protein for cell death, offers way to kill cancer cells by forcing them into programmed-death pathway
When cells suffer too much DNA damage, they are usually forced to undergo programmed cell death, or apoptosis. However, cancer cells often ignore these signals, flourishing even after chemotherapy drugs have ...
Genetics
May 14, 2013 |
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Shutting down DNA construction: How senescence halts growth of potential cancers
Researchers from The Wistar Institute explain a new molecular mechanism behind the phenomenon of oncogene-induced senescence. By depriving the cell of the ability to make new nucleotides—the building blocks ...
Cancer
Apr 04, 2013 |
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New chemo drug gentler on fertility, tougher on cancer
A new gentler chemotherapy drug in the form of nanoparticles has been designed by Northwestern Medicine® scientists to be less toxic to a young woman's fertility but extra tough on cancer. This is the first cancer drug tested ...
Cancer
Mar 22, 2013 |
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Accelerating drug development
All human clinical trials of new treatments begin with phase I, where drugs are tested in isolation to confirm their safety. Yet most effective cancer treatments use a combination of drugs, so-called 'multi-agent' ...
Medications
Mar 08, 2013 |
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Compound stimulates tumor-fighting protein in cancer therapy
A compound that stimulates the production of a tumor-fighting protein may improve the usefulness of the protein in cancer therapy, according to a team of researchers.
Cancer
Feb 06, 2013 |
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New target for treating wide spectrum of cancers
(Medical Xpress)—UC Irvine biologists, chemists and computer scientists have identified an elusive pocket on the surface of the p53 protein that can be targeted by cancer-fighting drugs. The finding heralds a new treatment ...
Cancer
Jan 31, 2013 |
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Cancer stem cells isolated from kidney tumors
Scientists have isolated cancer stem cells that lead to the growth of Wilms' tumours, a type of cancer typically found in the kidneys of young children. The researchers have used these cancer stem cells to test a new therapeutic ...
Cancer
Dec 13, 2012 |
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Temple scientists target DNA repair to eradicate leukemia stem cells
Despite treatment with imatinib, a successful drug that targets chronic myeloid leukemia (CML), a deadly type of cancer, some patients may continue to be at risk for relapse because a tiny pool of stem cells is resistant ...
Cancer
Dec 09, 2012 |
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Researchers link new molecular culprit to breast cancer progression
(Phys.org)—Johns Hopkins researchers have uncovered a protein "partner" commonly used by breast cancer cells to unlock genes needed for spreading the disease around the body. A report on the discovery, published November ...
Cancer
Nov 25, 2012 |
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Researchers uncover new target for cancer research
In a new paper released today in Nature, BioFrontiers Institute scientists at the University of Colorado Boulder, Tom Cech and Leslie Leinwand, detailed a new target for anti-cancer drug development that is sitting at the ...
Cancer
Oct 24, 2012 |
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Cell death mystery yields new suspect for cancer drug development
A mysterious form of cell death, coded in proteins and enzymes, led to a discovery by UNC researchers uncovering a prime suspect for new cancer drug development.
Cancer
Sep 13, 2012 |
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'CYCLOPS' genes may serve as an Achilles' heel in tumor cells
BOSTON--The genomic tumult within tumor cells has provided scientists at Dana-Farber Cancer Institute and the Broad Institute of MIT and Harvard with clues to an entirely new class of genes that may serve as an Achilles' ...
Genetics
Aug 15, 2012 |
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Protein that helps tumor blood vessels mature could make cancer drugs more effective
Since anti-cancer drugs are carried to tumors by the bloodstream, abnormal blood vessel development can hamper delivery. In a paper published Aug. 14 in Cancer Cell, researchers at Sanford-Burnham Medica ...
Cancer
Aug 13, 2012 |
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Lower risk of serious side-effects in trials of new targeted drugs
Patients in early clinical trials of new-style targeted cancer therapies appear to have a much lower risk of the most serious side-effects than with traditional chemotherapy, according to a new analysis.
Cancer
Aug 07, 2012 |
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Scientists develop mouse model that could lead to new therapies for liver cancer
Researchers have created the first mouse model demonstrating the role of a cancer promoting gene, Astrocyte elevated gene-1 (AEG-1), in hepatocellular carcinoma, or liver cancer. The mouse model represents a critical step ...
Cancer
Jul 06, 2012 |
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