Researchers identify gene variations that predict chemotherapy side effects
Seemingly benign differences in genetic code from one person to the next could influence who develops side effects to chemotherapy, a Mayo Clinic study has found. The study identified gene variations that can predispose people ...
Cancer
Apr 09, 2013 |
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New treatment holds promise for resistant lung cancer
A new chemotherapy regimen appears to produce minimal side effects in patients with lung cancer that has not responded to previous therapy, paving the way for additional research to determine if the new regimen also helps ...
Cancer
Apr 09, 2013 |
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Misregulated genes common to tobacco-related cancers offer potential new prognostic tool
Believe it or not, while researchers have explored which genes are mutated in each type of tobacco-associated cancer, until now no one had thought to look across these types for common genes that might predict patient outcomes. ...
Cancer
Apr 09, 2013 |
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Patients with BRCA1 mutations, but not BRCA2 mutations, had poorer prognosis compared with noncarriers
Patients with breast cancer who had a BRCA1 mutation had significantly worse overall and recurrence-free survival rates compared with patients without BRCA mutations, but no evidence for a difference in survival was found ...
Cancer
Apr 09, 2013 |
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Novel AKT pathway inhibitor, ARQ 092, demonstrated safety, effective target inhibition
Researchers have confirmed that the novel oral agent ARQ 092 inhibits the AKT pathway and has a manageable safety profile in patients with a variety of advanced solid tumors, according to phase I data presented at the AACR ...
Cancer
Apr 09, 2013 |
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New brain cancer treatment may be more effective, less toxic
(Medical Xpress)—A Phase 2 clinical trial testing a new protocol for treating a relatively rare form of brain cancer, primary CNS lymphoma, may change the standard of care for this disease, according to ...
Cancer
Apr 09, 2013 |
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Adding cetuximab to chemotherapy enables patients with advanced colorectal cancer, liver metastasis to undergo surgery
New results from a clinical trial conducted in Shanghai, China, indicate that adding cetuximab (Erbitux) to standard chemotherapy enables some patients with otherwise inoperable liver metastases due to colorectal cancer have ...
Cancer
Apr 08, 2013 |
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New Mayo software identifies and stratifies risk posed by lung nodules
A multidisciplinary team of researchers at Mayo Clinic has developed a new software tool to noninvasively characterize pulmonary adenocarcinoma, a common type of cancerous nodule in the lungs. Results from a pilot study of ...
Cancer
Apr 08, 2013 |
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Heart surgery increases death risk for cancer survivors who had radiation
Cancer survivors who had chest radiation are nearly twice as likely to die in the years after having major heart surgery as similar patients who didn't have radiation, according to research in the American Heart Association ...
Cardiology
Apr 08, 2013 |
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Certain breast cancer patients may benefit from combined HER2 targeted therapy without chemotherapy
Is the era of targeted therapy for breast cancer at hand? It could be, said experts at the Lester and Sue Smith Breast Center at Baylor College of Medicine – at least for a certain population of women.
Cancer
Apr 08, 2013 |
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Protein's well-known cousin sheds light on its gout-linked relative
Johns Hopkins scientists have found out how a gout-linked genetic mutation contributes to the disease: by causing a breakdown in a cellular pump that clears an acidic waste product from the bloodstream. By comparing this ...
Medical research
Apr 08, 2013 |
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Nearly half of breast cancer patients at risk of having BRCA mutations not sent for genetic testing
Only 53 percent of newly diagnosed breast cancer patients who were at high risk of carrying a BRCA 1 or BRCA 2 mutation – based on age, diagnosis, and family history of breast or ovarian cancer – reported that their doctors ...
Cancer
Apr 08, 2013 |
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Possible predictive biomarker for patients who may respond to autophagy inhibitors
Autophagy, the process by which cells that are starved for food resort to chewing up their own damaged proteins and membranes and recycling them into fuel, has emerged as a key pathway that cancer cells use to survive in ...
Cancer
Apr 08, 2013 |
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Biomarkers discovered that may help predict response to drugs targeting KRAS-mutated NSCLC
Scientists have identified biomarkers that may help predict whether patients with KRAS-mutated non-small cell lung cancer (NSCLC) will respond to concurrent treatment with an MEK inhibitor and a PI3 kinase inhibitor, a drug ...
Cancer
Apr 08, 2013 |
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Preclinical study indicates potential for novel inhibitor to overcome drug resistance induced by RAF, MEK inhibitors
A new class of investigational medicines may help to treat patients with cancers driven by mutations in genes such as BRAF or KRAS/NRAS, including those patients who have become resistant to therapies that target BRAF directly, ...
Cancer
Apr 08, 2013 |
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