Neuroscience

Review: Levetiracetam best monotherapy for partial seizures

(HealthDay)—Levetiracetam performs better than carbamazepine and lamotrigine for individuals with partial seizures, according to a review and meta-analysis published online June 29 in the Cochrane Library.

Cardiology

Carbamazepine affects warfarin anticoagulation

(HealthDay)—For warfarin-treated patients, carbamazepine co-treatment is associated with subtherapeutic anticoagulative effect and increased warfarin dose requirements, according to a study published online Jan. 21 in the ...

Psychology & Psychiatry

Lithium reduces risk of suicide in people with mood disorders

The authors say the drug "seems to reduce the risk of death and suicide by more than 60% compared with placebo" and suggest this review "reinforces lithium as an effective agent to reduce the risk of suicide in people with ...

Autism spectrum disorders

Exposure to antiepileptic drug in womb linked to autism risk

Children whose mothers take the antiepileptic drug sodium valproate while pregnant are at significantly increased risk of autism and other neurodevelopmental disorders, suggests a small study published online in the Journal ...

Diseases, Conditions, Syndromes

Nodding disease confounds experts, kills children

Patrick Anywar, 14, lies curled up naked in the dust and midday heat of a Ugandan village, struggling to look up at his younger brother and sister playing in front of the family home.

Cardiology

Vascular risk linked to long-term antiepileptic drug therapy

New research reveals that patients with epilepsy who were treated for extended periods with older generation antiepileptic drugs (AEDs) may be at increased risk for developing atherosclerosis, a common disorder known as hardening ...

Health

Study: Medications in NYC water not a health risk

(AP) -- Tiny amounts of pharmaceuticals and personal care products detected in the drinking water of the nation's biggest city continue to pose no public health risks to residents, environmental officials said Friday.

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Carbamazepine

Carbamazepine (CBZ) is an anticonvulsant and mood-stabilizing drug used primarily in the treatment of epilepsy and bipolar disorder, as well as trigeminal neuralgia. It is also used off-label for a variety of indications, including attention-deficit hyperactivity disorder (ADHD), schizophrenia, phantom limb syndrome, complex regional pain syndrome, paroxysmal extreme pain disorder, neuromyotonia, intermittent explosive disorder, borderline personality disorder and post-traumatic stress disorder.

It has been seen as safe for pregnant women to use carbamazepine as a mood stabilizer, but, like other anticonvulsants, intrauterine exposure is associated with spina bifida and neurodevelopmental problems.

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