Oncology & Cancer

DDX41: A key nuclear player in maintaining genomic stability

The gene DDX41 encodes the nuclear enzyme, DEAD-box-type RNA helicase. Mutation of DDX41 leads to hematopoietic cancers. However, the mechanism underlying this malignancy development is unclear. To this end, researchers from ...

Diabetes

Research unlocks the circuitry of diabetes

Research led by Pamela-Itkin-Ansari, Ph.D., and Randal Kaufman Ph.D., has mapped out a network of biochemical interactions that help special cells in the pancreas called islet cells create insulin, shedding light on the origins ...

Obstetrics & gynaecology

Vaginal immune system may hint at prime vaccine timing

Levels of key immune-signaling molecules in the vagina "undergo clear and consistent" fluctuations during the menstrual cycle, a University of Washington Medicine-led team reports in a study published today in the journal ...

Oncology & Cancer

New understanding of how faulty metabolism triggers adrenal cancer

Researchers have deciphered a signaling cascade through which inborn errors in metabolism provoke deadly neuroendocrine tumors in the adrenal glands. This discovery explains how impaired metabolism due to mutations in a key ...

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