News tagged with cell lines
Related topics: cells , lung cancer , cancer cells , embryonic stem cells
New screening approach identified potential drug combos for difficult-to-treat melanomas
A novel approach to identifying potential anticancer drug combinations revealed that pairing cholesterol-reducing drugs called statins with cyclin-dependent kinase inhibitors might provide an effective approach to treating ...
Cancer
Dec 13, 2012 |
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Understanding of the mechanisms of drug resistance to dual-agent chemotherapy in ovarian cancer
More than half of all patients with ovarian cancer experience recurrent disease and will eventually fail to respond to chemotherapy. The failure of chemotherapy is usually due to the development of resistance to the two main ...
Cancer
Nov 29, 2012 |
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A sip of resveratrol and a full p53: Ingredients for a successful cell death
Researchers at the Universidade Federal in Rio de Janeiro in Brazil have found that introduction of a normal copy of the p53 gene in p53-defective cancer cell lines makes these cells sensitive to the anti-tumor proprieties ...
Medical research
Nov 13, 2012 |
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Scientists test 5,000 combinations of 100 existing cancer drugs to find more effective treatments
Scientists in the United States have tested all possible pairings of the 100 cancer drugs approved for use in patients in order to discover whether there are any combinations not tried previously that are effective in certain ...
Cancer
Nov 06, 2012 |
4.3 / 5 (3) |
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Wnt5a protein critical to gut lining repair
Scientists at Washington University School of Medicine in St. Louis have identified a protein essential to repairing the intestine's inner lining.
Medical research
Sep 06, 2012 |
4 / 5 (3) |
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Researchers validate molecular signature to predict radiation therapy benefit
Researchers at Moffitt Cancer Center, working with colleagues in Sweden, the Netherlands and Puerto Rico, have validated a radiosensitivity molecular signature that can lead to better radiation therapy decisions for treating ...
Cancer
Aug 16, 2012 |
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Researchers find driver of breast cancer stem cell metastasis
The finding involves the cancer gene RhoC, which has previously been shown to promote metastasis of many types of cancer. RhoC levels increase as breast cancer progresses and high levels of RhoC are associated with worse ...
Cancer
Jul 24, 2012 |
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Misidentified and contaminated cell lines lead to faulty cancer science
Modern cancer therapies start in cells – researchers compare cancer samples to healthy cells to discover how cancer is genetically different, and use cell lines to test promising new drugs. However, a University of Colorado ...
Cancer
Jun 21, 2012 |
5 / 5 (1) |
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Not all tumor cells are equal: Study reveals huge genetic diversity in cells shed by tumors
The cells that slough off from a cancerous tumor into the bloodstream are a genetically diverse bunch, Stanford University School of Medicine researchers have found. Some have genes turned on that give them the potential ...
Cancer
May 07, 2012 |
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KRAS gene mutation and amplification status affects sensitivity to antifolate therapy
Testing patients with non-small cell lung cancer for both mutations and amplifications of the KRAS gene prior to therapy may help to predict response to treatment with antifolates, according to the updated results of a preclinical ...
Cancer
Apr 04, 2012 |
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First volume of the Cancer Cell Line Encyclopedia made public
The goal of cancer treatment is to match the right drug to the right target in the right patient. But before such "personalized" drugs can be developed, more knowledge is needed about specific genomic alterations in cancers ...
Cancer
Mar 28, 2012 |
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Double whammy: RNAi enhances lung cancer therapy
Non-small cell lung cancer (NSCLC), the most common form of lung cancer, is usually treated with surgery and chemotherapy. However, a small group of patients can also be helped by treatment with tyrosine kinase inhibitors ...
Cancer
Mar 20, 2012 |
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Viruses kill pancreatic tumors in preclinical model
(Medical Xpress) -- An intra-tumor injection of a virus prevented further growth of some pancreatic tumors and eradicated others in mouse models of pancreatic ductal adenocarcinoma. However, some tumors continued growing ...
Medical research
Mar 20, 2012 |
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New class of potential drugs inhibits inflammation in brain
Scientists at Emory University School of Medicine have identified a new group of compounds that may protect brain cells from inflammation linked to seizures and neurodegenerative diseases.
Neuroscience
Feb 14, 2012 |
4.5 / 5 (4) |
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CD97 gene expression and function correlate with WT1 protein expression and glioma invasiveness
Researchers at Virginia Commonwealth University Medical Center's VCU Massey Cancer Center and Harold F. Young Neurosurgical Center (Richmond, VA) and Old Dominion University (Norfolk, VA) have discovered that suppression ...
Neuroscience
Feb 07, 2012 |
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