News tagged with cell nucleus
Related topics: genes , cancer cells , protein , gene expression , genetic material
Discovery of Mer protein in leukemia cells' nuclei may be new, druggable target
Since the mid-1990s, doctors have had the protein Mer in their sights – it coats the outside of cancer cells, transmitting signals inside the cells that aid their uncontrolled growth.
Cancer
Mar 13, 2012 |
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Cancer epigenetics: Breakthrough in ID'ing target genes
Cancer is usually attributed to faulty genes, but growing evidence from the field of cancer epigenetics indicates a key role for the gene "silencing" proteins that stably turn genes off inside the cell nucleus. ...
Cancer
Mar 13, 2012 |
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Aurora-A hinders tumor-suppressor to allow chemotherapy resistance
A protein abundantly found in treatment-resistant cancers holds an important tumor-suppressor out of the cell nucleus, where it would normally detect DNA damage and force defective cells to kill themselves, a team of scientists ...
Cancer
Feb 27, 2012 |
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To understand chromosome reshuffling, look to the genome's 3D structure
That our chromosomes can break and reshuffle pieces of themselves is nothing new; scientists have recognized this for decades, especially in cancer cells. The rules for where chromosomes are likely to break and how the broken ...
Medical research
Feb 16, 2012 |
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SUMO-snipping protein plays crucial role in T and B cell development
When SUMO grips STAT5, a protein that activates genes, it blocks the healthy embryonic development of immune B cells and T cells unless its nemesis breaks the hold, a research team led by scientists at The University of Texas ...
Genetics
Jan 27, 2012 |
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How protein networks stabilize muscle fibers: Same mechanism as for DNA
The same mechanism that stabilises the DNA in the cell nucleus is also important for the structure and function of vertebrate muscle cells. This has been established by RUB-researchers led by Prof. Dr. Wolfgang Linke (Institute ...
Genetics
Jan 23, 2012 |
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How the brain puts the brakes on the negative impact of cocaine
Research published by Cell Press in the January 12 issue of the journal Neuron provides fascinating insight into a newly discovered brain mechanism that limits the rewarding impact of cocaine. The study describes protective delaye ...
Neuroscience
Jan 11, 2012 |
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Brain strain: Christmas shopping when money tight
(AP) -- Chennel King, a nurse from Norwalk, Conn., went Christmas shopping the other day with a new holiday companion: a budget.
Psychology & Psychiatry
Dec 18, 2011 |
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Researchers engineer blood stem cells to fight melanoma
Researchers from UCLA's cancer and stem cell centers have demonstrated for the first time that blood stem cells can be engineered to create cancer-killing T-cells that seek out and attack a human melanoma. The researchers ...
Cancer
Nov 28, 2011 |
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Non-coding RNA relocates genes when it's time to go to work
Cells develop and thrive by turning genes on and off as needed in a precise pattern, a process known as regulated gene transcription. In a paper published in the Nov. 9 issue of the Journal of Neuroscience, researchers at the ...
Neuroscience
Nov 10, 2011 |
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How major signaling pathways are wired to our genome gives new insight into disease processes
Whitehead Institute scientists have determined that master transcription factors determine the genes regulated by key signaling pathways. In this way, signaling pathways are targeted to genes that are most relevant to each ...
Medical research
Oct 27, 2011 |
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Protein that fuels lethal breast cancer growth emerges as potential new drug target
A protein in the nucleus of breast cancer cells that plays a role in fueling the growth of aggressive tumors may be a good target for new drugs, reports a research team at the Duke Cancer Institute.
Cancer
Oct 17, 2011 |
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Study finds clue to birth defects in babies of mothers with diabetes
In a paper published today in Diabetologia, a team at Joslin Diabetes Center, headed by Mary R. Loeken, PhD, has identified the enzyme AMP kinase (AMPK) as key to the molecular mechanism that significantly increases the ri ...
Diseases, Conditions, Syndromes
Oct 17, 2011 |
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Confirmation that vitamin D acts as a protective agent against the advance of colon cancer
The indication that vitamin D and its derivatives have a protective effect against various types of cancer is not new. In the field of colon cancer, numerous experimental and epidemiological studies show that vitamin D3 (or ...
Cancer
Aug 16, 2011 |
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Lawson researchers take control of cancer
According to the Canadian Cancer Society, one in four Canadians will die of cancer. This year alone, the disease will kill an estimated 75,000 people. With incidence rates on the rise, more cancer patients are facing grave ...
Cancer
Jul 28, 2011 |
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