Increased stability of a misfolded protein linked to age of onset of common form of motor neuron disease
Neurodegenerative diseases are characterized by the aggregation of misfolded proteins, which accumulate to form insoluble clumps within or around nerve cells. In the adult motor neuron disease amyotrophic ...
Medical research
Apr 22, 2013 |
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Protecting against aging at the molecular level
Research from Western University and Lawson Health Research Institute sheds new light on a gene called ATRX and its function in the brain and pituitary. Children born with ATRX syndrome have cognitive defects and developmental ...
Medical research
Apr 08, 2013 |
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Measuring enzyme levels in cancer patients may reveal healthy cells' ability to survive chemotherapy
New research from MIT may allow scientists to develop a test that can predict the severity of side effects of some common chemotherapy agents in individual patients, allowing doctors to tailor treatments ...
Genetics
Apr 05, 2013 |
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New clues to causes of peripheral nerve damage
(Medical Xpress)—Anyone whose hand or foot has "fallen asleep" has an idea of the numbness and tingling often experienced by people with peripheral nerve damage. The condition also can cause a range of ...
Neuroscience
Mar 07, 2013 |
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How chromosomes keep their loose ends loose
We take it for granted that our chromosomes won't stick together, yet this kind of cellular disaster would happen constantly were it not for a protein called TRF2. Now, scientists at The Scripps Research Institute (TSRI) ...
Medical research
Feb 06, 2013 |
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Scientists find key element of lupus, suggesting better drug targets
A team led by scientists at The Scripps Research Institute (TSRI) has identified specific cellular events that appear key to lupus, a debilitating autoimmune disease that afflicts tens of millions of people worldwide. The ...
Medical research
Feb 04, 2013 |
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Promising new finding for therapies to treat persistent seizures in epileptic patients
In a promising finding for epileptic patients suffering from persistent seizures known as status epilepticus, researchers reported today that new medication could help halt these devastating seizures. To ...
Neuroscience
Jan 16, 2013 |
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Previously unknown mechanism identified in oncogene-induced senescence
Cell aging, or cellular senescence, has an important role in the natural physiological response to tumor development. Activated oncogenes are able to induce senescence, and recent findings have suggested that oncogene-induced ...
Cancer
Dec 12, 2012 |
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HCMV researchers utilize novel techniques to show preferential repair of the viral genome
A new study about Human Cytomegalovirus (HCMV), a leading cause of birth defects, reveals how the virus co-opts cells' abilities to repair themselves. In the paper published on November 29 in the Open Access journal PLOS Pa ...
Diseases, Conditions, Syndromes
Nov 29, 2012 |
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Enzyme inhibition protects against Huntington's disease damage in two animal models
Treatment with a novel agent that inhibits the activity of SIRT2, an enzyme that regulates many important cellular functions, reduced neurological damage, slowed the loss of motor function and extended survival in two animal ...
Neuroscience
Nov 29, 2012 |
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Plant-based diets can remedy chronic diseases
According to the World Health Organization (WHO), 63 percent of the deaths that occurred in 2008 were attributed to non-communicable chronic diseases such as cardiovascular disease, certain cancers, Type 2 diabetes and obesity—for ...
Health
Oct 17, 2012 |
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Inhibiting CaMKII enzyme activity could lead to new therapies for heart disease
University of Iowa researchers have previously shown that an enzyme called CaM kinase II plays a pivotal role in the death of heart cells following a heart attack or other conditions that damage or stress heart muscle. Loss ...
Cardiology
Oct 11, 2012 |
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Researchers find cause of chemotherapy resistance in melanoma
Researchers with UC Irvine's Chao Family Comprehensive Cancer Center have identified a major reason why melanoma is largely resistant to chemotherapy.
Cancer
Sep 17, 2012 |
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Study shows vitamin E may decrease cancer risk in Cowden syndrome patients
Cleveland Clinic researchers have discovered that vitamin E may prevent cancer in patients with an under-recognized genetic disorder.
Cancer
Sep 17, 2012 |
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How gene profiling in emphysema is helping to find a cure
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death in the United States and is thought to affect almost three million people in the UK. New research published in BioMed Central's open access ...
Genetics
Aug 31, 2012 |
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