Cellular gatekeepers do more than open doors for drugs, study finds
(Medical Xpress)—The cellular gatekeepers that escort the most common pharmaceuticals into our cells continue to work within the cells as well, according to a UC San Francisco discovery that could transform drug design ...
Medical research
Apr 08, 2013 |
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Hope in stopping melanoma from spreading: Study shows that inhibiting key protein prevents metastasis to lungs in mice
(Medical Xpress)—Researchers have identified a critical protein role in the metastasis of melanoma, the most serious form of skin cancer. Inhibition of the protein known as adenosine diphosphate ribosylation ...
Cancer
Mar 05, 2013 |
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How chromosomes keep their loose ends loose
We take it for granted that our chromosomes won't stick together, yet this kind of cellular disaster would happen constantly were it not for a protein called TRF2. Now, scientists at The Scripps Research Institute (TSRI) ...
Medical research
Feb 06, 2013 |
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HCMV researchers utilize novel techniques to show preferential repair of the viral genome
A new study about Human Cytomegalovirus (HCMV), a leading cause of birth defects, reveals how the virus co-opts cells' abilities to repair themselves. In the paper published on November 29 in the Open Access journal PLOS Pa ...
Diseases, Conditions, Syndromes
Nov 29, 2012 |
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Recently uncovered human counterparts to a subset of mouse immune cells may enable better vaccination strategies
Mice have made an immeasurable contribution to medicine and our overall understanding of human disease. This animal model is not without its limitations, however, and scientists are continually learning about ...
Medical research
Oct 24, 2012 |
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In cancer, an embryonic gene-silencing mechanism gone awry
There are some genes that are only activated in the very first days of an embryo's existence. Once they have accomplished their task, they are shut down forever, unlike most of our genes, which remain active throughout our ...
Genetics
Oct 04, 2012 |
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Scientists reprogram cancer cells with low doses of epigenetic drugs
Experimenting with cells in culture, researchers at the Johns Hopkins Kimmel Cancer Center have breathed possible new life into two drugs once considered too toxic for human cancer treatment. The drugs, azacitidine (AZA) ...
Cancer
Mar 22, 2012 |
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Discovery provides blueprint for new drugs that can inhibit hepatitis C virus
Chemists at the University of California, San Diego have produced the first high resolution structure of a molecule that when attached to the genetic material of the hepatitis C virus prevents it from reproducing.
Medical research
Mar 19, 2012 |
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Researchers discover key to immune cell's 'internal guidance' system
University of British Columbia researchers have discovered the molecular pathway that enables receptors inside immune cells to find, and flag, fragments of pathogens trying to invade a host.
Immunology
Feb 05, 2012 |
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Preventing dangerous nonsense in human gene expression
Human genes are preferentially encoded by codons that are less likely to be mistranscribed (or "misread") into a STOP codon. This finding by Brian Cusack and colleagues from the Max Planck Institute for Molecular Genetics ...
Genetics
Oct 13, 2011 |
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How cells sense nutrients and fuel cancer cell growth
In cancer, genes turn on and off at the wrong times, proteins aren't folded properly, and cellular growth and proliferation get out of control. Even a cancer cell's metabolism goes haywire, as it loses the ability to appropriately ...
Medical research
Oct 06, 2011 |
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New targets for the control of HIV predicted using a novel computational analysis
A new computational approach has predicted numerous human proteins that the human immunodeficiency virus (HIV) requires to replicate itself. These discoveries "constitute a powerful resource for experimentalists who desire ...
HIV & AIDS
Sep 22, 2011 |
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Fail-safe system may lead to cures for inherited disorders
Scientists at the University of California, San Diego School of Medicine have uncovered a previously unknown fail-safe (compensatory) pathway that potentially protects the brain and other organs from genetic and environmental ...
Medical research
Sep 15, 2011 |
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Dual-action protein developed better restricts blood vessel formation
(Medical Xpress) -- Cancer needs blood. In fact, some cancer medications work solely to slow or prevent cancer cells from creating new capillaries, choking off their much-needed blood and nutrient supply to halt the growth ...
Medical research
Aug 09, 2011 |
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Researchers link cell division and oxygen levels
Cells grow abundant when oxygen is available, and generally stop when it is scarce. Although this seems straightforward, no direct link ever has been established between the cellular machinery that senses oxygen and that ...
Medical research
Jun 11, 2011 |
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