Metabolic biomarkers can predict mortality in the ICU
A metabolic profile of intensive care unit (ICU) patients based on biomarkers of four metabolites can be used to accurately predict mortality, according to a new study.
Diseases, Conditions, Syndromes
23 hours ago |
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What role do processing bodies play in cell survival and protection against viral infection?
As scientists learn more about processing bodies (PBs), granules present within normal cells, they are unraveling the complex role PBs play in maintaining cellular homeostasis by regulating RNA metabolism ...
Medical research
May 16, 2013 |
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Structure that edits messenger RNA transcripts defective in two different forms of motor neuron diseases
Amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA) are degenerative motor neuron diseases in which the key mutated genes are involved in RNA metabolism. This similarity suggests that a ...
Medical research
Apr 26, 2013 |
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Uncleaned cells mean weak muscles
The protein complex mTORC1 promotes muscle growth. However, should this complex remain constantly active, it impairs the ability of the cells to self-clean, causing myopathy. Scientists working with Markus ...
Medical research
Apr 23, 2013 |
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Hundreds of alterations and potential drug targets to starve cancer tumors identified
A massive study analyzing gene expression data from 22 tumor types has identified multiple metabolic expression changes associated with cancer. The analysis, conducted by researchers at Columbia University Medical Center, ...
Cancer
Apr 21, 2013 |
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Researchers identify critical metabolic alterations in triple-negative breast cancer cells
Researchers at Fox Chase Cancer Center have identified a host of small molecules critical to metabolism in cells of triple-negative breast cancer—one of the least understood groups of breast cancer. These molecules, called ...
Cancer
Apr 09, 2013 |
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Researchers find that alcohol consumption damages brain's support cells
Alcohol consumption affects the brain in multiple ways, ranging from acute changes in behavior to permanent molecular and functional alterations. The general consensus is that in the brain, alcohol targets mainly neurons. ...
Neuroscience
Mar 18, 2013 |
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Protein in fat cells that stimulates inflammatory signaling helps put gears in motion for onset of diet-induced obesity
Poor diet and lifestyle choices set the stage for obesity and diabetes, but the immune system plays a relatively underappreciated role in accelerating this process. Metabolic changes in fat cells stimulate ...
Medical research
Mar 15, 2013 |
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BRAF inhibitor treatment causes melanoma cells to shift how they produce energy
A multi-institutional study has revealed that BRAF-positive metastatic malignant melanomas develop resistance to treatment with drugs targeting the BRAF/MEK growth pathway through a major change in metabolism. The findings, ...
Cancer
Mar 08, 2013 |
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Cancer-promoting protein found to also suppress cell growth
Some cellular proteins have multiple, and occasionally opposing, functions. Professor Adrian Krainer [link: Faculty profile] and colleagues at Cold Spring Harbor Laboratory demonstrate in a paper published online today in ...
Medical research
Mar 07, 2013 |
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Stem cell survival strategy key to blood and immune system health
Stem cells of the aging bone marrow recycle their own molecules to survive and keep replenishing the blood and immune systems as the body ages, researchers at UC San Francisco (UCSF) have discovered.
Medical research
Feb 14, 2013 |
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Diabetes drug could hold promise for lung cancer patients
Ever since discovering a decade ago that a gene altered in lung cancer regulated an enzyme used in therapies against diabetes, Reuben Shaw has wondered if drugs originally designed to treat metabolic diseases ...
Cancer
Jan 29, 2013 |
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Circadian rhythms can be modified for potential treatment of disorders
(Medical Xpress)—UC Irvine-led studies have revealed the cellular mechanism by which circadian rhythms – also known as the body clock – modify energy metabolism and also have identified novel compounds that control ...
Cardiology
Jan 22, 2013 |
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Metabolomics key to identifying disease pathway: Research reveals lactic acid's role in lung disease
(Medical Xpress)—Expertise at Pacific Northwest National Laboratory contributed to the understanding of the role of cellular metabolism in the pathogenesis of a currently untreatable lung disease. This ...
Diseases, Conditions, Syndromes
Jan 14, 2013 |
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UCSB researchers perform pioneering research on Type 2 diabetes
– While legions of medical researchers have been looking to understand the genetic basis of disease and how mutations may affect human health, a group of biomedical researchers at UC Santa Barbara is studying ...
Diabetes
Jan 04, 2013 |
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