Despite the positive advances that anti-human immunodeficiency virus (HIV) therapy, commonly called anti-retroviral therapy (ART) or highly active antiretroviral therapy (HAART), has had on the life expectancy of HIV-positive ...
Mar 8, 2021
0
43
Effector regulatory T cells (eTreg cells) are a specialized subset of white blood cells that keep the immune system in check. St. Jude Children's Research Hospital scientists have revealed the metabolic signaling mechanisms ...
Nov 17, 2020
0
49
Deleting the TSC2 gene in specific lung cells of mice led to the activation of the mTORC1 signaling pathway and pulmonary disease characteristics consistent with human LAM disease, particularly in female breeder mice. These ...
Nov 9, 2020
0
221
More than 100 cancer types can arise all over the body, but two universal metabolic pathways may tie them all together, researchers from the Perelman School of Medicine at the University of Pennsylvania report in a new study ...
Nov 9, 2020
0
162
There are common vulnerabilities among three lethal coronaviruses, SARS-CoV-2, SARS-CoV-1 and MERS-CoV, such as frequently hijacked cellular pathways, that could lead to promising targets for broad coronavirus inhibition, ...
Oct 15, 2020
0
71
Researchers at Children's Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania have identified a cellular pathway that can be targeted with a naturally occurring drug to stimulate ...
Sep 28, 2020
0
344
Researchers in China have discovered how brain cancer cells increase production of a key protein that allows them to evade the body's immune system. The study, which will be published August 27 in the Journal of Experimental ...
Aug 27, 2020
0
5
The COVID-19 pandemic caused by the new coronavirus has created an unprecedented public health challenge globally. Little was known about how the infecting cells respond to the virus and how the virus hijacks the host cellular ...
Jul 24, 2020
0
9
From organisms as simple as worms to those as complex as humans, sleep is a fundamental necessity. But although an estimated 50 to 70 million people in the United States suffer from a chronic sleep disorder, the genetic mechanisms ...
Nov 14, 2019
0
201
Researchers at Winship Cancer Institute of Emory University have discovered that an apparent "dead end metabolite" has a previously unknown function regulating cell growth. The finding could guide efforts to target cancer ...
Oct 4, 2019
0
6
