News tagged with cellular senescence

Study discovers that stem cell senescence drives aging

Declining levels of the protein BubR1 occur when both people and animals age, and contribute to cell senescence or deterioration, weight loss, muscle wasting and cataracts. Mayo Clinic researchers have shown that adult progenitor ...

Medical research Apr 18, 2013 | 5 / 5 (5) | 0 |

Scientists use luminescent mice to track cancer and aging in real-time

In a study published in the January 18 issue of Cell, researchers from the University of North Carolina Lineberger Comprehensive Cancer Center have developed a new method to visualize aging and tumor growth ...

Medical research Jan 17, 2013 | 5 / 5 (5) | 1 |

Medical researchers decoding the aging process

Scientists are beginning to decode the complex biology of aging and are optimistic that recent advances in research may lead to treatments that can slow or even reverse degeneration and disease.

Medical research Nov 15, 2011 | 4.6 / 5 (15) | 5

Researchers discover tactic to delay age-related disorders

Researchers at Mayo Clinic have shown that eliminating cells that accumulate with age could prevent or delay the onset of age-related disorders and disabilities. The study, performed in mouse models, provides the first evidence ...

Medical research Nov 02, 2011 | 5 / 5 (7) | 2 |

Hard-to-treat Myc-driven cancers may be susceptible to drug already used in clinic

Drugs that are used in the clinic to treat some forms of breast and kidney cancer and that work by inhibiting the signaling molecule mTORC1 might have utility in treating some of the more than 15 percent of human cancers ...

Cancer Dec 14, 2012 | not rated yet | 0

Previously unknown mechanism identified in oncogene-induced senescence

Cell aging, or cellular senescence, has an important role in the natural physiological response to tumor development. Activated oncogenes are able to induce senescence, and recent findings have suggested that oncogene-induced ...

Cancer Dec 12, 2012 | not rated yet | 0

Genetics of melanoma chemoresistance

Malignant melanoma is a highly aggressive and notoriously chemoresistant form of cancer. In a new paper, Ohanna et al. reveal that anti-melanoma drugs may, paradoxically, induce a senescence-associated secretory profile ("secretome") ...

Cancer Jun 06, 2011 | not rated yet | 0