Study finds mutations linked to relapse of childhood leukemia
After an intensive three-year hunt through the genome, medical researchers have pinpointed mutations that leads to drug resistance and relapse in the most common type of childhood cancer—the first time anyone has linked ...
Genetics
Feb 03, 2013 |
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Study finds new genetic defects in high-risk childhood leukemia subtypes with chromosomal loss
Research led by St. Jude Children's Research Hospital scientists has identified a possible lead in treatment of two childhood leukemia subtypes known for their dramatic loss of chromosomes and poor treatment outcomes.
Genetics
Jan 20, 2013 |
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Key to fighting drug-resistant leukemia found
Doctors who treat children with the most common form of childhood cancer – acute lymphoblastic leukemia – are often baffled at how sometimes the cancer cells survive their best efforts and the most powerful modern ...
Cancer
May 18, 2011 |
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Study finds potential link between auto pollution, some childhood cancers
Scientists from UCLA's Fielding School of Public Health led by Julia Heck, an assistant researcher in the school's epidemiology department and a member of UCLA's Jonsson Comprehensive Cancer Center, have found a possible ...
Cancer
Apr 09, 2013 |
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T-cell therapy eradicates an aggressive leukemia in two children
Two children with an aggressive form of childhood leukemia had a complete remission of their disease-showing no evidence of cancer cells in their bodies-after treatment with a novel cell therapy that reprogrammed their immune ...
Cancer
Mar 25, 2013 |
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Gene sequencing project identifies abnormal gene that launches rare childhood leukemia
Research led by the St. Jude Children's Research Hospital – Washington University Pediatric Cancer Genome Project has identified a fusion gene responsible for almost 30 percent of a rare subtype of childhood leukemia with ...
Cancer
Nov 12, 2012 |
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Scientific progress could be casualty in public health vs. privacy debate over newborn blood samples
The tremendous potential public health benefits of research with blood samples left over after routine newborn screening must not be lost amidst controversy and litigation, say medical and bioethics experts in a commentary ...
Other
Nov 07, 2012 |
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Existing drugs offer new treatment options for high-risk childhood leukemia subtype
Scientists have identified new genetic alterations underlying a high-risk subtype of the most common childhood cancer that could be effectively targeted with existing leukemia therapies.
Cancer
Aug 13, 2012 |
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Tobacco smoke affects early human embryonic development
(Medical Xpress) -- Scientists have gained insight into how second-hand tobacco smoke damages the earliest stages of human embryonic development.
Medical research
Mar 16, 2012 |
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Researchers develop first 'theranostic' treatment for acute lymphoblastic leukemia (ALL)
A team of researchers at Case Western Reserve University School of Medicine has developed the first "theranostic" agent for the treatment of acute lymphoblastic leukemia (ALL). ALL is the most common type of childhood cancer ...
Cancer
Mar 07, 2012 |
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Newly identified DNA repair defect linked to increased risk of leukemia relapse
A newly identified defect in a DNA repair system might leave some young leukemia patients less likely to benefit from a key chemotherapy drug, possibly putting them at greater risk of relapse. The problem was identified in ...
Medical research
Sep 26, 2011 |
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Epigenetic pathway and new drug show promise in reversing a hard-to-treat childhood cancer
A difficult-to-treat form of childhood leukemia relies on changes in the structure of DNA – so-called epigenetic changes – to wreak genomic havoc within white blood cells, according to one of two studies conducted ...
Cancer
Jul 11, 2011 |
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Zebrafish models identify high-risk genetic features in leukemia patients
Leukemia is the most common childhood cancer; it also occurs in adults. Now researchers working with zebrafish at Huntsman Cancer Institute (HCI) at the University of Utah have identified previously undiscovered high-risk ...
Genetics
May 10, 2011 |
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Immunotherapy showed promising antileukemia activity in pediatric patients
Researchers using patients' own immune cells in an immunotherapy approach called "anti-CD19 chimeric antigen receptor (CAR) T-cell therapy," achieved responses in children whose acute lymphocytic leukemia (ALL) had returned ...
Cancer
Apr 07, 2013 |
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Engineered immune cells produce complete response in child with an aggressive pediatric leukemia
By reprogramming a 7-year-old girl's own immune cells to attack an aggressive form of childhood leukemia, a pediatric oncologist has achieved a complete response in his patient, who faced grim prospects when she relapsed ...
Cancer
Dec 09, 2012 |
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