News tagged with cisplatin

Related topics: cancer cells , tumor cells , cancer , chemotherapy , chemotherapy drugs

Making cancer drugs better

More than half of all cancer patients who receive chemotherapy are treated with drugs containing platinum. These drugs are very powerful, but like many other chemotherapy agents, they can have side effects ...

Apr 03, 2014
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Nearly all men survive testicular cancer

Survival for testicular cancer has risen by almost 30 per cent in the last 40 years, with nearly all men now beating the disease, according to figures published by Cancer Research UK.

Jul 29, 2013
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Preventing eggs' death from chemotherapy

Young women who have cancer treatment often lose their fertility because chemotherapy and radiation can damage or kill their immature ovarian eggs, called oocytes. Now, Northwestern Medicine scientists have found the molecular ...

Jun 17, 2013
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Pretesting cervical tumors could inform treatment

(Medical Xpress)—Doctors at Washington University School of Medicine in St. Louis have shown that testing cervical tumors before treatment for vulnerability to chemotherapy predicts whether patients will ...

May 31, 2013
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Individual efficacy of chemotherapies

The function of the mitochondria – also defined as "power plants" within the cells – is essential as to whether, and how, some chemotherapeutic agents take effect in tissue. Scientists at the Helmholtz ...

May 10, 2013
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Study reveals how melanoma evades chemotherapy

Nitric oxide (NO), a gas with many biological functions in healthy cells, can also help some cancer cells survive chemotherapy. A new study from MIT reveals one way in which this resistance may arise, and ...

Apr 08, 2013
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ERCC1 not effective for guiding therapeutic decisions

(HealthDay)—Currently available antibodies for the excision repair cross-complementation group 1 (ERCC1) protein are not adequate for therapeutic decision-making regarding the potential efficacy of cisplatin-containing ...

Mar 21, 2013
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Cisplatin

Cisplatin, cisplatinum, or cis-diamminedichloroplatinum(II) (CDDP) (trade names Platinol and Platinol-AQ) is a chemotherapy drug. It is used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas, and germ cell tumors. It was the first member of a class of platinum-containing anti-cancer drugs, which now also includes carboplatin and oxaliplatin. These platinum complexes react in vivo, binding to and causing crosslinking of DNA, which ultimately triggers apoptosis (programmed cell death).

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