Using patient data from six major U.S. cancer centers, Brigham researchers and collaborators developed a risk prediction model for moderate-to-severe kidney injury after receiving the chemotherapy drug cisplatin in the largest, ...
Mar 27, 2024
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Tisch Cancer Institute researchers have discovered that a certain type of chemotherapy improves the immune system's ability to fight off bladder cancer, particularly when combined with immunotherapy.
Jan 26, 2024
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Chemotherapy-induced nausea and vomiting (CINV) are among the most prevalent and distressing side effects faced by patients undergoing antineoplastic treatments. This condition can lead to complications such as dehydration, ...
Dec 13, 2023
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A clinical trial co-led by Mount Sinai researchers is the first to show that using chemotherapy with immunotherapy resulted in improved survival in patients with an advanced type of bladder cancer. The results were simultaneously ...
Oct 22, 2023
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For the 314,000 people diagnosed with ovarian cancer each year, hope often comes in the form of platinum-based drugs such as cisplatin.
Sep 6, 2023
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Cisplatin is a potent chemotherapeutic agent used to treat various cancers, including cervical cancer. But the continued use of cisplatin can lead to the development of cisplatin resistance and other side effects, like chemotherapy-induced ...
Jul 20, 2023
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Prostate cancer is a leading cause of death among American men, and it's resistant to one of the most powerful chemotherapy medications—cisplatin. Now, researchers reporting in ACS Central Science have developed the first ...
Jul 13, 2023
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With the United States facing a high number of drug shortages, a Chinese company may help to boost the supply of one in particular, the chemotherapy agent cisplatin.
Jun 5, 2023
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Cisplatin is widely used as a chemotherapeutic agent for the treatment of various solid tumors, including bladder, ovarian, and esophageal tumors. However, on metabolism by an enzyme called "cysteine conjugate beta-lyase ...
May 23, 2023
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Researchers at Cleveland Clinic have taken an important step in predicting which treatment will work for individual cancer patients. Using a gene signature developed from cell lines and human tissue, the research team demonstrated ...
Apr 20, 2023
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Cisplatin, cisplatinum, or cis-diamminedichloroplatinum(II) (CDDP) (trade names Platinol and Platinol-AQ) is a chemotherapy drug. It is used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas, and germ cell tumors. It was the first member of a class of platinum-containing anti-cancer drugs, which now also includes carboplatin and oxaliplatin. These platinum complexes react in vivo, binding to and causing crosslinking of DNA, which ultimately triggers apoptosis (programmed cell death).
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