Monoclonal antibodies directed against tumor antigens have proven effective for treating some forms of cancer. Despite the increasing use of monoclonal antibody therapy, it is not clear how these antibodies drive tumor removal.
Jan 16, 2014
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Researchers replicated human pancreatic beta cells—which produce insulin—in a mouse model in which donor cells were transplanted. The newly replicated cells retained features of mature beta cells and showed a physiological ...
Jan 16, 2014
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Individuals with asthma and COPD are subject to debilitating bronchospasm as a result of airways that are hyperresponsive to stimuli. Factors that lead to the development of airway hyperresponsiveness are not well characterized.
Jan 9, 2014
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The effectiveness of toxin-neutralizing antibodies is considered to be mediated through the interaction of the variable region of the antibody and the toxin; however, recent studies suggest that the constant region (Fc) of ...
Jan 9, 2014
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Bone homeostasis requires precise balance between deposition of new bone by osteoblasts and resorption of old bone by osteoclasts. Bone diseases, including osteoporosis and rheumatoid arthritis, are the result of increased ...
Dec 9, 2013
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Patients with the autoimmune disease systemic lupus erythematosus (SLE) produce autoantibodies that target can cause damage to multiple organ systems. The host factors that are targeted by autoantibodies produced by SLE patients ...
Nov 25, 2013
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Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer deaths worldwide. Current therapies that target cellular kinases have been effective for some patients: however, many individuals with NSCLS do not ...
Nov 8, 2013
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One of the most devastating side effects of diabetes is kidney failure, and one of the earliest signs of kidney damage is a disruption of the organ's filtering capacity. Diabetes patients who develop kidney failure must go ...
Nov 8, 2013
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Vitamin D deficiency has been associated with kidney disease including fibrosis. Some studies have even suggested that treatment with vitamin D or vitamin D analogs can reduce renal fibrosis; however, the pathways targeted ...
Oct 25, 2013
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Pancreatic cancer is one of the most deadly and intractable forms of cancer, with a 5-year survival rate of only 6%. Novel therapies are urgently needed, as conventional and targeted approaches have not been successful and ...
Jul 8, 2013
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