News tagged with clinical trials
Scientists uncover molecular roots of cocaine addiction in the brain
Researchers at Johns Hopkins have unraveled the molecular foundations of cocaine's effects on the brain, and identified a compound that blocks cravings for the drug in cocaine-addicted mice. The compound, already proven safe ...
Neuroscience
May 22, 2013 |
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New sleeping pill poised to hit US markets
An experimental sleeping pill from US drug company Merck is effective at helping people fall and stay asleep, according to reviewers at the US Food and Drug Administration, which could soon approve the new drug.
Medications
May 21, 2013 |
4.2 / 5 (5) |
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'Gap' for HIV vaccine efforts after latest setback
The hunt for an HIV vaccine has gobbled up $8 billion in the past decade, and the failure of the most recent efficacy trial has delivered yet another setback to 26 years of efforts.
HIV & AIDS
May 19, 2013 |
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Scientists develop drug that slows Alzheimer's in mice
A drug developed by scientists at the Salk Institute for Biological Studies, known as J147, reverses memory deficits and slows Alzheimer's disease in aged mice following short-term treatment. The findings, ...
Alzheimer's disease & dementia
May 13, 2013 |
4.2 / 5 (5) |
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Lyme disease vaccine shows promise in clinical trial
(Medical Xpress)—The results of a phase 1/2 clinical trial in Europe of an investigational Lyme disease vaccine co-developed by researchers at Stony Brook University, Brookhaven National Laboratory, and at Baxter International ...
Medications
May 13, 2013 |
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Optimal vitamin D dosage for infants uncertain
In a comparison of the effect of different dosages of vitamin D supplementation in breastfed infants, no dosage raised and maintained plasma concentrations within a range recommended by some pediatric societies. However, ...
Health
Apr 30, 2013 |
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Italy approves law on controversial stem cell therapy (Update)
Italian lawmakers on Wednesday gave their final approval to a law that allows limited use of a controversial type of stem cell therapy which has been condemned by many scientists but has given hope to families of terminally-ill ...
Medical research
May 22, 2013 |
5 / 5 (1) |
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Early use of tracheostomy for mechanically ventilated patients not associated with improved survival
For critically ill patients receiving mechanical ventilation, early tracheostomy (within the first 4 days after admission) was not associated with an improvement in the risk of death within 30 days compared to patients who ...
Other
May 21, 2013 |
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Better behavior after tonsil/adenoid surgery for kids with sleep breathing trouble?
Children with obstructive sleep apnea who had a common surgery to remove their tonsils and adenoids showed notable improvements in behavior, quality of life and other symptoms compared to those treated with "watchful waiting" ...
Sleep apnea
May 21, 2013 |
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Effect of fluid and sodium restrictions on weight loss among patients with heart failure
A clinical trial of 75 patients hospitalized with acute decompensated heart failure (ADHF) suggests that aggressive fluid and sodium restriction has no effect on weight loss or clinical stability at three days but was associated ...
Cardiology
May 20, 2013 |
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First prospective trial shows molecular profiling timely for tailoring therapy
A clinical trial has shown that patients, and their physicians, are eager to jump into next-era cancer care—analysis of an individual's tumor to find and target genetic mutations that drive the cancer. Results of the study, ...
Cancer
May 15, 2013 |
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Operating without interrupting warfarin reduces risk of bleeding after cardiac device surgery
A new Canadian study shows that operating without interrupting warfarin treatment at the time of cardiac device surgery is safe and markedly reduces the incidence of clinically significant hematomas compared to the current ...
Cardiology
May 09, 2013 |
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Anti-hypertension drug may improve schizophrenia symptoms
(Medical Xpress)—An anti-hypertension drug administered intravenously for a single four-hour treatment resulted in dramatic improvements of symptoms for people living with schizophrenia, according to newly published findings ...
Psychology & Psychiatry
May 09, 2013 |
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Treatment for painful curved penis shows promise
(HealthDay)—Some diseases are especially tough to discuss. When Tony Lee realized that his penis was curving whenever he had an erection—making it painful and difficult for him to have sex—he had no ...
Diseases, Conditions, Syndromes
May 08, 2013 |
4.7 / 5 (3) |
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Scientists identify early predictors of disease progression which could speed Huntington's disease drug trials
Scientists have identified a set of tests that could help identify whether and how Huntington's disease (HD) is progressing in groups of people who are not yet showing symptoms. The latest findings from the TRACK-HD study, ...
Neuroscience
May 08, 2013 |
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Clinical trial
In clinical trials are conducted to allow safety and efficacy data to be collected for new drugs or devices. These trials can only take place once satisfactory information has been gathered on the quality of the product and its non-clinical safety, and Health Authority/Ethics Committee approval is granted in the country where the trial is taking place.
Depending on the type of product and the stage of its development, investigators enroll healthy volunteers and/or patients into small pilot studies initially, followed by larger scale studies in patients that often compare the new product with the currently prescribed treatment. As positive safety and efficacy data are gathered, the number of patients is typically increased. Clinical trials can vary in size from a single center in one country to multicenter trials in multiple countries.
Due to the sizable cost a full series of clinical trials may incur, the burden of paying for all the necessary people and services is usually borne by the sponsor who may be the pharmaceutical or biotechnology company that developed the agent under study. Since the diversity of roles may exceed resources of the sponsor, often a clinical trial is managed by an outsourced partner such as a contract research organization
For more information about Clinical trial, read the full article at
Wikipedia.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
