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Cocaine

Cocaine (benzoylmethylecgonine) is a crystalline tropane alkaloid that is obtained from the leaves of the coca plant. The name comes from "coca" in addition to the alkaloid suffix -ine, forming cocaine. It is both a stimulant of the central nervous system and an appetite suppressant. Specifically, it is a dopamine reuptake inhibitor, a norepinephrine reuptake inhibitor and a serotonin reuptake inhibitor, which mediates functionality of such as an exogenous DAT ligand. Because of the way it affects the mesolimbic reward pathway, cocaine is addictive.

Its possession, cultivation, and distribution are illegal for non-medicinal and non-government sanctioned purposes in virtually all parts of the world. Although its free commercialization is illegal and has been severely penalized in virtually all countries, its use worldwide remains widespread in many social, cultural, and personal settings.

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Scientists uncover molecular roots of cocaine addiction in the brain

Researchers at Johns Hopkins have unraveled the molecular foundations of cocaine's effects on the brain, and identified a compound that blocks cravings for the drug in cocaine-addicted mice. The compound, already proven safe ...

Neuroscience created May 22, 2013 | popularity not rated yet | comments 0 | with audio podcast

Excessive soda can mimic illicit drug use effects on teeth

(HealthDay)—Manifestation of dental erosion caused by illicit drug use or excessive soda consumption needs to be distinguished from dental caries, according to case studies published in the March/April ...

Dentistry created May 13, 2013 | popularity 5 / 5 (1) | comments 0

Twin epidemics: HIV and Hepatitis C in the urban Northeast

A new Yale study looks at the scope and consequences of a burgeoning health problem in the cities of the U.S. Northeast: concurrent infection with both HIV and Hepatitis C (HCV). The study appears online ...

HIV & AIDS created May 17, 2013 | popularity not rated yet | comments 0

Cocaine vaccine passes key testing hurdle

Researchers at Weill Cornell Medical College have successfully tested their novel anti-cocaine vaccine in primates, bringing them closer to launching human clinical trials. Their study, published online by the journal Neuropsychopharmacology, used a ...

Psychology & Psychiatry created May 10, 2013 | popularity 5 / 5 (2) | comments 0 | with audio podcast