Researchers at the Broad Institute of MIT and Harvard, Cambridge, have interrogated several interconnected questions related to mitochondrial DNA (mtDNA) heteroplasmy and the influence of nuclear genetics.
In one of the first genome-wide studies to hunt for both genes and their regulatory "tags" in patients suffering from a common disease, researchers have found a clear role for the tags in mediating genetic risk for rheumatoid ...
Jan 20, 2013
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By decoding the genomes of more than 1,000 people whose homelands stretch from Africa and Asia to Europe and the Americas, scientists have compiled the largest and most detailed catalog yet of human genetic variation. The ...
Oct 31, 2012
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Stress wreaks havoc on the mind and body. For example, psychological stress is associated with greater risk for depression, heart disease and infectious diseases. But, until now, it has not been clear exactly how stress influences ...
Apr 2, 2012
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A new statistical tool developed by researchers at the University of Chicago improves the ability to find genetic variants that cause disease. The tool, described in a new paper published January 26, 2024, in Nature Genetics, ...
Jan 26, 2024
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Genome-wide association studies (GWAS) on patient blood samples are useful for identifying the genetic basis of blood cell traits and their links to common diseases. While previous experiments have focused on characterizing ...
Dec 15, 2023
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Gene therapy has great promise for treating genetic diseases, and even for more common diseases such as atherosclerosis (hardening of the arteries). Over the past decade, the gene-editing technology CRISPR (Clustered Regularly ...
Nov 16, 2023
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Many common diseases such as arteriosclerosis and diabetes or neurodegenerative diseases such as Alzheimer's are associated with inflammatory processes. A better understanding of these processes is therefore an important ...
Nov 2, 2023
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Polygenic risk scores, which estimate a person's disease risk based on thousands or millions of common genetic variants, perform poorly in screening and prediction of common diseases such as heart disease, according to a ...
Oct 17, 2023
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A new study finds that consanguinity—unions between close relatives—may increase the risk of common diseases such as type 2 diabetes and post-traumatic stress disorder (PTSD).
Sep 26, 2023
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