Inside embryonic cells, specific proteins control the rate at which genetic information is transcribed from DNA to messenger RNA—a crucial regulatory step before proteins are created. Then, organs develop and hopefully ...
Apr 27, 2022
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Small chemical changes in the DNA building blocks, which may be influenced by lifestyle factors, can reduce the amount of IGFBP2. A DIfE / DZD research team has now reported in the journal Diabetes that these epigenetic changes ...
Nov 9, 2018
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Our immune system is working every day to protect us from bacteria, viruses, and parasites, but it can also detect when our own cells are damaged.
Sep 6, 2018
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People with Rett Syndrome, a rare and debilitating neurodevelopmental disorder, exhibit many autism-like traits. Now researchers at MIT have identified a protein that plays an important role in the disorder. The researchers ...
Jul 25, 2016
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For years, scientists have struggled to find a way to block a protein known to play an important role in many cancers. The protein, STAT3, acts as a transcription factor—it performs the crucial task of helping convert DNA ...
Nov 19, 2015
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Penn Medicine researchers have discovered that hypermethylation - the epigenetic ability to turn down or turn off a bad gene implicated in 10 to 30 percent of patients with Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal ...
Mar 20, 2015
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In a new study published today in Cell Reports, scientists at the Fred Hutchinson Cancer Research Center demonstrate that mice lacking one copy of a gene called CTCF have abnormal DNA methylation and are markedly predisposed ...
May 2, 2014
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(Medical Xpress)—Scientists from the FMI identify how a family of proteins reads the methylation marks on the DNA so critical for cell development. These MBD proteins bind directly to methylation marks and inactivate the ...
Apr 12, 2013
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Researchers at Sanford-Burnham Medical Research Institute have determined the complete three-dimensional structure of a protein called HNF-4α. HNF-4α controls gene expression in the liver and pancreas, switching genes on ...
Mar 13, 2013
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A mysterious form of cell death, coded in proteins and enzymes, led to a discovery by UNC researchers uncovering a prime suspect for new cancer drug development.
Sep 13, 2012
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