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News tagged with dna damage response


Wip1 could be new target for cancer treatment

Researchers have uncovered mutations in the phosphatase Wip1 that enable cancer cells to foil the tumor suppressor p53, according to a study in The Journal of Cell Biology. The results could provide a new ...

Cancer created May 06, 2013 | popularity not rated yet | comments 0

Mitochondrial metabolic regulator SIRT4 guards against DNA damage

(Medical Xpress)—Healthy cells don't just happen. As they grow and divide, they need checks and balances to ensure they function properly while adapting to changing conditions around them.

Cancer created Apr 05, 2013 | popularity 5 / 5 (4) | comments 2 | with audio podcast

How chromosomes keep their loose ends loose

We take it for granted that our chromosomes won't stick together, yet this kind of cellular disaster would happen constantly were it not for a protein called TRF2. Now, scientists at The Scripps Research Institute (TSRI) ...

Medical research created Feb 06, 2013 | popularity 5 / 5 (3) | comments 0 | with audio podcast

Study finds linchpin of skin response to UVA light

Last year, a team of researchers at Brown University discovered that certain skin cells use a light-sensitive receptor found outside of the eye to sense ultraviolet light and quickly begin pumping out melanin ...

Medical research created Jan 21, 2013 | popularity 4.3 / 5 (3) | comments 0 | with audio podcast

Previously unknown mechanism identified in oncogene-induced senescence

Cell aging, or cellular senescence, has an important role in the natural physiological response to tumor development. Activated oncogenes are able to induce senescence, and recent findings have suggested that oncogene-induced ...

Cancer created Dec 12, 2012 | popularity not rated yet | comments 0

Proteins in DNA damage response network targeted for new therapies, researchers say

(Medical Xpress)—Researchers at Moffitt Cancer Center and colleagues at the University of South Florida; Duke University; Johns Hopkins University; the Brazilian National Cancer Institute; and the Rio de Janeiro Federal ...

Medical research created Oct 16, 2012 | popularity 5 / 5 (1) | comments 0 | with audio podcast

Zinc deficiency mechanism linked to aging, multiple diseases

(Medical Xpress)—A new study has outlined for the first time a biological mechanism by which zinc deficiency can develop with age, leading to a decline of the immune system and increased inflammation associated ...

Medical research created Oct 01, 2012 | popularity not rated yet | comments 0 | with audio podcast

Researchers find cause of chemotherapy resistance in melanoma

Researchers with UC Irvine's Chao Family Comprehensive Cancer Center have identified a major reason why melanoma is largely resistant to chemotherapy.

Cancer created Sep 17, 2012 | popularity not rated yet | comments 0 | with audio podcast

Detector of DNA damage: Structure of a repair factor revealed

Double-stranded breaks in cellular DNA can trigger tumorigenesis. Researchers from Ludwig-Maximilians-Universitaet (LMU) in Munich, Germany, have determined the structure of a protein involved in the repair and signaling ...

Medical research created Jun 19, 2012 | popularity 5 / 5 (1) | comments 0

Three is the magic number: A chain reaction required to prevent tumor formation

Protein p53 is known for controlling the life and death of a cell and has a key role in cancer research. P53 is known to be inactive in 50 percent of cancer patients. If researchers succeed in re-establishing the presence ...

Cancer created Jan 20, 2012 | popularity 5 / 5 (1) | comments 0

New take on impacts of low dose radiation

Researchers with the U.S. Department of Energy (DOE)'s Lawrence Berkeley National Laboratory (Berkeley Lab), through a combination of time-lapse live imaging and mathematical modeling of a special line of ...

Cancer created Dec 20, 2011 | popularity 4.5 / 5 (11) | comments 4 | with audio podcast

At last, a reason why stress causes DNA damage

For years, researchers have published papers that associate chronic stress with chromosomal damage.

Medical research created Aug 21, 2011 | popularity 5 / 5 (13) | comments 7 | with audio podcast

Researchers discover possible drug targets for common non-Hodgkin's lymphoma

Researchers at the University of Maryland School of Medicine have discovered a novel interaction between two proteins involved in regulating cell growth that could provide possible new drug targets for treating diffuse large ...

Cancer created Jul 19, 2011 | popularity 5 / 5 (2) | comments 0 | with audio podcast

Malaria vaccination strategy provides model for superior protection

Malaria is a devastating disease caused by the Plasmodium parasite which is transmitted to humans by infected mosquitoes. Hundreds of millions of new cases of malaria are reported each year, and there are more than 750,000 ...

Medical research created Jun 15, 2011 | popularity not rated yet | comments 0 | with audio podcast

Genetics of melanoma chemoresistance

Malignant melanoma is a highly aggressive and notoriously chemoresistant form of cancer. In a new paper, Ohanna et al. reveal that anti-melanoma drugs may, paradoxically, induce a senescence-associated secretory profile ("secretome") ...

Cancer created Jun 06, 2011 | popularity not rated yet | comments 0


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