News tagged with dna damage
(Medical Xpress)—Scientists supported by the National Institutes of Health have a new theory as to why a woman's fertility declines after her mid-30s. They also suggest an approach that might help slow ...
Medical research May 22, 2013 | not rated yet | 0 |
Study IDs key protein for cell death, offers way to kill cancer cells by forcing them into programmed-death pathway
When cells suffer too much DNA damage, they are usually forced to undergo programmed cell death, or apoptosis. However, cancer cells often ignore these signals, flourishing even after chemotherapy drugs have ...
Genetics May 14, 2013 | 5 / 5 (9) | 0 |
The understanding of how a powerful protein called p53 protects against cancer development has been upended by a discovery by Walter and Eliza Hall Institute researchers.
Cancer May 09, 2013 | 4 / 5 (1) | 0 |
(HealthDay)—The red in redheads' hair is thought to put them at increased risk of the dangerous skin cancer melanoma, even if they don't spend a lot of time in the sun, according to a new study.
Cancer May 09, 2013 | not rated yet | 2 |
Researchers have uncovered mutations in the phosphatase Wip1 that enable cancer cells to foil the tumor suppressor p53, according to a study in The Journal of Cell Biology. The results could provide a new ...
Cancer May 06, 2013 | not rated yet | 0
Researchers at Moffitt Cancer Center have found that a deficiency in an important anti-tumor protein, p53, can slow or delay DNA repair after radiation treatment. They suggest that this is because p53 regulates the expression ...
Cancer Apr 23, 2013 | 4 / 5 (1) | 0 |
Research from Western University and Lawson Health Research Institute sheds new light on a gene called ATRX and its function in the brain and pituitary. Children born with ATRX syndrome have cognitive defects and developmental ...
Medical research Apr 08, 2013 | 5 / 5 (1) | 0
A novel combination of two drugs has shown anti-cancer activity in patients who had incurable solid tumors and carried a germline mutation in their BRCA genes, Dana-Farber Cancer Institute researchers are reporting at the ...
Cancer Apr 07, 2013 | 5 / 5 (1) | 0
Measuring enzyme levels in cancer patients may reveal healthy cells' ability to survive chemotherapy
New research from MIT may allow scientists to develop a test that can predict the severity of side effects of some common chemotherapy agents in individual patients, allowing doctors to tailor treatments ...
Genetics Apr 05, 2013 | not rated yet | 0 |
(Medical Xpress)—Healthy cells don't just happen. As they grow and divide, they need checks and balances to ensure they function properly while adapting to changing conditions around them.
Cancer Apr 05, 2013 | 5 / 5 (4) | 2 |
Scientists at the Gladstone Institutes have discovered that a certain type of DNA damage long thought to be particularly detrimental to brain cells can actually be part of a regular, non-harmful process. The team further ...
Alzheimer's disease & dementia Mar 24, 2013 | 5 / 5 (7) | 1 |
Cancer drug imatinib (Glivec) could boost radiotherapy treatment to destroy bladder cancer that has spread to the bladder wall, reveals research published in Cancer Research.
Cancer Mar 04, 2013 | not rated yet | 0
Researchers from the College of Pharmacy and Medical School working within the Masonic Cancer Center, University of Minnesota, have partnered to identify genetic variations that may help signal which acute myeloid leukemia ...
Cancer Feb 26, 2013 | 5 / 5 (1) | 0 |
Over two fifths (43 per cent) of people in the UK who have used sunbeds – which are proven to prematurely age the skin – are using anti-ageing products. This compares with only a fifth (20 per cent) ...
Cancer Feb 21, 2013 | not rated yet | 0
Researchers at Moffitt Cancer Center have found a potential targeted therapy for patients with tobacco-associated non-small cell lung cancer. It is based on the newly identified oncogene IKBKE, which helps regulate immune ...
Cancer Feb 15, 2013 | not rated yet | 0 |
DNA repair refers to a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. In human cells, both normal metabolic activities and environmental factors such as UV light and Radiation can cause DNA damage, resulting in as many as 1 million individual molecular lesions per cell per day. Many of these lesions cause structural damage to the DNA molecule and can alter or eliminate the cell's ability to transcribe the gene that the affected DNA encodes. Other lesions induce potentially harmful mutations in the cell's genome, which affect the survival of its daughter cells after it undergoes mitosis. Consequently, the DNA repair process is constantly active as it responds to damage in the DNA structure.
The rate of DNA repair is dependent on many factors, including the cell type, the age of the cell, and the extracellular environment. A cell that has accumulated a large amount of DNA damage, or one that no longer effectively repairs damage incurred to its DNA, can enter one of three possible states:
The DNA repair ability of a cell is vital to the integrity of its genome and thus to its normal functioning and that of the organism. Many genes that were initially shown to influence lifespan have turned out to be involved in DNA damage repair and protection. Failure to correct molecular lesions in cells that form gametes can introduce mutations into the genomes of the offspring and thus influence the rate of evolution.
For more information about DNA repair, read the full article at
This text uses material from Wikipedia and is available under the GNU Free Documentation License.