News tagged with dna methylation
Related topics: genes , cancer , dna sequences , gene expression , embryonic stem cells
DNA methylation is a type of chemical modification of DNA that can be inherited and subsequently removed without changing the original DNA sequence. As such, it is part of the epigenetic code and is also the best characterized epigenetic mechanism. Because methylation is a common capability of all viruses for self non-self identification, the epigenetic code could be a persistent remnant of ancient viral infection events.
DNA methylation involves the addition of a methyl group to DNA — for example, to the number 5 carbon of the cytosine pyrimidine ring — in this case with the specific effect of reducing gene expression. DNA methylation at the 5 position of cytosine has been found in every vertebrate examined. In adult somatic tissues, DNA methylation typically occurs in a CpG dinucleotide context; non-CpG methylation is prevalent in embryonic stem cells.
In plants, cytosines are methylated both symmetrically (CpG or CpNpG) and asymmetrically (CpNpNp), where N can be any nucleotide but guanine.
Research has suggested that long term memory storage in humans may be regulated by DNA methylation.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
A large, multi-institutional research team involved in the NIH Epigenome Roadmap Project has published a sweeping analysis in the current issue of the journal Cell of how genes are turned on and off to direct early human ...
Genetics May 09, 2013 | 5 / 5 (3) | 0 |
A Big Data analysis that integrates three large sets of genomic data available through The Cancer Genome Atlas has identified 37 RNA molecules that might predict survival in patients with the most common form of breast cancer.
Cancer Apr 29, 2013 | not rated yet | 0 |
Scientists from King's College London have identified patterns of epigenetic changes involved in autism spectrum disorder (ASD) by studying genetically identical twins who differ in autism traits. The study, published in ...
Autism spectrum disorders Apr 23, 2013 | 3 / 5 (1) | 1 |