News tagged with dna methylation

Related topics: genes , cancer , dna sequences , gene expression , embryonic stem cells

New study explains evolution of duplicate genes

From time to time, living cells will accidently make an extra copy of a gene during the normal replication process. Throughout the history of life, evolution has molded some of these seemingly superfluous ...

Apr 07, 2014
popularity 4.8 / 5 (8) | comments 7

BPA affects sex-based behavior in mice

(Medical Xpress)—Bisphenol A (BPA) is a common chemical found in household plastics. Previous studies on rodents show that BPA exposure is associated with problems with brain and behavioral development. ...

May 28, 2013
popularity 5 / 5 (8) | comments 5 | with audio podcast report

Possible role for Huntington's gene discovered

About 20 years ago, scientists discovered the gene that causes Huntington's disease, a fatal neurodegenerative disorder that affects about 30,000 Americans. The mutant form of the gene has many extra DNA ...

Jan 16, 2013
popularity 5 / 5 (3) | comments 0 | with audio podcast

DNA methylation

DNA methylation is a type of chemical modification of DNA that can be inherited and subsequently removed without changing the original DNA sequence. As such, it is part of the epigenetic code and is also the best characterized epigenetic mechanism. Because methylation is a common capability of all viruses for self non-self identification, the epigenetic code could be a persistent remnant of ancient viral infection events.

DNA methylation involves the addition of a methyl group to DNA — for example, to the number 5 carbon of the cytosine pyrimidine ring — in this case with the specific effect of reducing gene expression. DNA methylation at the 5 position of cytosine has been found in every vertebrate examined. In adult somatic tissues, DNA methylation typically occurs in a CpG dinucleotide context; non-CpG methylation is prevalent in embryonic stem cells.

In plants, cytosines are methylated both symmetrically (CpG or CpNpG) and asymmetrically (CpNpNp), where N can be any nucleotide but guanine.

Research has suggested that long term memory storage in humans may be regulated by DNA methylation.

This text uses material from Wikipedia licensed under CC BY-SA