A combination of the PARP inhibitor olaparib (Lynparza) and the investigational ATR inhibitor ceralasertib showed clinical benefit in pediatric patients with solid tumors exhibiting DNA replication stress and/or DNA repair ...
Apr 18, 2023
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In 2022, an estimated 7,000 Canadians were diagnosed with leukemia, a term used to define cancer of the blood cells. Of that 7,000, it is estimated that nearly half will face mortality. University of Saskatchewan (USask) ...
Feb 7, 2023
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Northwestern Medicine scientists have identified disease-causing DNA variants in two genes linked to neurodevelopmental deficits including microcephaly in children, according to findings published in Nature Communications.
Dec 15, 2022
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The gene DDX41 encodes the nuclear enzyme, DEAD-box-type RNA helicase. Mutation of DDX41 leads to hematopoietic cancers. However, the mechanism underlying this malignancy development is unclear. To this end, researchers from ...
Nov 18, 2022
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Error-prone DNA replication and repair may lead to mutations and cancer in individuals who inherit a mutant copy of the BRCA1 gene, according to a new study by Weill Cornell Medicine investigators. The discovery has potential ...
Nov 15, 2022
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In the tough war against glioblastoma, scientists are taking a cue from viruses on how to make the aggressive cancer more vulnerable to treatment.
Nov 1, 2022
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Genetic mutations kick start cancers. Some mutations shuffle the genetic code, others come from the deletion of key genes.
Oct 27, 2022
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36
Researchers have uncovered a novel pathway that explains how cancer cells become resistant to chemotherapies, which in turn offers a potential solution for preventing chemo-resistance.
Sep 20, 2022
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43
A new research perspective published in Oncoscienceexplores SLFN11's surveillance role in protein homeostasis.
Aug 3, 2022
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6
Scientists have found that non-coding "junk" DNA, far from being harmless and inert, could potentially contribute to the development of cancer.
Jul 19, 2022
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