News tagged with drug delivery
(Medical Xpress)—The blood-brain barrier (BBB) prevents most large or hydrophilic (polar) molecules from getting into the brain. For many neurological diseases, like Parkinson's, the presence of the BBB ...
Medical research Apr 30, 2013 | 5 / 5 (2) | 0 |
About 15 years ago, MIT professors Robert Langer and Michael Cima had the idea to develop a programmable, wirelessly controlled microchip that would deliver drugs after implantation in a patient's body. This ...
Medical research Feb 16, 2012 | 5 / 5 (3) | 1 |
The trouble with most anti-cancer therapies is that they are lethal to most cells in the body, not just cancer cells. As a result, patients experience side effects like nausea, increased susceptibility to ...
Cancer Nov 21, 2011 | 5 / 5 (5) | 1 |
(Medical Xpress)—Washington University School of Medicine in St. Louis is playing a leading role in one of the National Institutes of Health's (NIH) first clinical trials to improve treatments for rare ...
Diseases, Conditions, Syndromes Apr 03, 2013 | not rated yet | 0 |
DNA, siRNA and miRNA can reprogram cancer cells – that is, if these nucleic acids could cross through the cell membrane. A University of Colorado Cancer Center study published today in the journal Therapeutic Delivery shows ...
Cancer Apr 02, 2013 | 4.5 / 5 (2) | 0 |
By loading fragile RNA into silicon nanoparticles, researchers from The Methodist Hospital and two other institutions found a new drug delivery system can reduce the size of ovarian tumors by as much as 83 ...
Cancer Feb 14, 2013 | not rated yet | 0 |
A team of UC Davis scientists has shown in experimental mouse models that a new drug delivery system allows for administration of three times the maximum tolerated dose of a standard drug therapy for advanced bladder cancer, ...
Cancer Oct 25, 2012 | not rated yet | 0 |
(Medical Xpress)—Kansas State University researchers have discovered a molecule that may be capable of delivering drugs inside the body to treat diseases.
Medical research Sep 24, 2012 | 5 / 5 (2) | 0 |
Using ultrasound waves, MIT engineers have found a way to enhance the permeability of skin to drugs, making transdermal drug delivery more efficient. This technology could pave the way for noninvasive drug ...
Medical research Sep 14, 2012 | 5 / 5 (2) | 0 |
A new delivery method for levodopa/carbidopa, a common dual-drug Parkinson's disease (PD) regimen, significantly improved the duration of the drugs' effectiveness in people with advanced PD, according to research by Mount ...
Parkinson's & Movement disorders Jun 20, 2012 | not rated yet | 0 |
A targeted, nanoparticle gelatin-based clot-busting treatment dissolved significantly more blood clots than a currently used drug in an animal study of acute coronary syndrome presented at the American Heart Association's ...
Cardiology Nov 14, 2011 | not rated yet | 0 |
Could engineered fatty particles help prevent AIDS? Liposomes block HIV infection in early tests; could be a cost-effective preventive for developing countries
HIV & AIDS Sep 19, 2011 | 5 / 5 (1) | 1 |
New research raises troubling concerns about the use of aggressive drug therapies to treat a wide range of diseases such as MRSA, C. difficile, malaria, and even cancer.
Diseases, Conditions, Syndromes Aug 03, 2011 | not rated yet | 0 |
Scientists have confirmed the feasibility of using a new drug delivery system the basis for a battery-powered skin patch to administer medication that shows promise for treating peripheral artery disease (PAD) ...
Medical research Aug 03, 2011 | 2 / 5 (1) | 0 |
Devices marketed as "electronic cigarettes" are in reality crude drug delivery systems for refined nicotine, posing unknown risks with little new benefits to smokers, according to tobacco control experts.
Health Jul 20, 2011 | not rated yet | 15 |
Drug delivery is the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals. Drug delivery technologies are patent protected formulation technologies that modify drug release profile, absorption, distribution and elimination for the benefit of improving product efficacy and safety, as well as patient convenience and compliance. Most common methods of delivery include the preferred non-invasive peroral (through the mouth), topical (skin), transmucosal (nasal, buccal/sublingual, vaginal, ocular and rectal) and inhalation routes. Many medications such as peptide and protein, antibody, vaccine and gene based drugs, in general may not be delivered using these routes because they might be susceptible to enzymatic degradation or can not be absorbed into the systemic circulation efficiently due to molecular size and charge issues to be therapeutically effective. For this reason many protein and peptide drugs have to be delivered by injection. For example, many immunizations are based on the delivery of protein drugs and are often done by injection.
Current efforts in the area of drug delivery include the development of targeted delivery in which the drug is only active in the target area of the body (for example, in cancerous tissues) and sustained release formulations in which the drug is released over a period of time in a controlled manner from a formulation. Types of sustained release formulations include liposomes, drug loaded biodegradable microspheres and drug polymer conjugates.
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